Detalhe da pesquisa
1.
PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation.
BMC Immunol
; 22(1): 78, 2021 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34920698
2.
Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor.
J Pharmacol Exp Ther
; 369(3): 443-453, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30940692
3.
The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.
Bioorg Med Chem
; 27(8): 1456-1478, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30858025
4.
Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.
J Med Chem
; 64(18): 13780-13792, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34510892
5.
Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.
Nat Commun
; 10(1): 5711, 2019 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31836714
6.
Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.
J Med Chem
; 59(15): 7239-51, 2016 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27429068
7.
Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.
J Med Chem
; 59(20): 9574, 2016 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27726364
8.
Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.
J Med Chem
; 59(17): 8148, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27548024
9.
Mouse models of allergic asthma: acute and chronic allergen challenge.
Dis Model Mech
; 1(4-5): 213-20, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-19093027