Detalhe da pesquisa
1.
Effect of the novel dual orexin receptor antagonist daridorexant on night-time respiratory function and sleep in patients with moderate chronic obstructive pulmonary disease.
J Sleep Res
; 30(4): e13248, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33417730
2.
Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y12 receptor antagonist, in patients with chronic coronary syndromes.
Eur Heart J
; 41(33): 3132-3140, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31994703
3.
Impact of the organic cation transporter 2 inhibitor cimetidine on the single-dose pharmacokinetics of the glucosylceramide synthase inhibitor lucerastat in healthy subjects.
Eur J Clin Pharmacol
; 76(3): 431-437, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31836927
4.
Absorption, distribution, metabolism, and excretion of cenerimod, a selective S1P1 receptor modulator in healthy subjects.
Xenobiotica
; 50(8): 947-956, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-32105166
5.
Absorption, distribution, metabolism and excretion of the P2Y12 receptor antagonist selatogrel after subcutaneous administration in healthy subjects.
Xenobiotica
; 50(4): 427-434, 2020 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-31322041
6.
Interaction potential of the dual orexin receptor antagonist ACT-541468 with CYP3A4 and food: results from two interaction studies.
Eur J Clin Pharmacol
; 75(2): 195-205, 2019 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-30284597
7.
Cardiodynamic Interactions between Two S1P1 Receptor Modulators in an Experimental Clinical Setting: Different Pharmacokinetic Properties as an Opportunity to Mitigate First-Dose Heart Rate Effects.
Int J Mol Sci
; 20(13)2019 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31266149
8.
In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics.
Eur J Clin Pharmacol
; 74(4): 455-464, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-29273968
9.
Effect of mavoglurant (AFQ056), a selective mGluR5 antagonist, on the pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and levonorgestrel in healthy women.
Int J Clin Pharmacol Ther
; 53(7): 550-6, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25943176
10.
Endocrine profile of the kisspeptin receptor agonist MVT-602 in healthy premenopausal women with and without ovarian stimulation: results from 2 randomized, placebo-controlled clinical tricals.
Fertil Steril
; 121(1): 95-106, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37925096
11.
Metabolism and disposition of the metabotropic glutamate receptor 5 antagonist (mGluR5) mavoglurant (AFQ056) in healthy subjects.
Drug Metab Dispos
; 41(9): 1626-41, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23775850
12.
Relationship of drug metabolizing enzyme genotype to plasma levels as well as myelotoxicity of cyclophosphamide in breast cancer patients.
Eur J Clin Pharmacol
; 68(4): 389-95, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22012257
13.
Abuse potential assessment of the new dual orexin receptor antagonist daridorexant in recreational sedative drug users as compared to suvorexant and zolpidem.
Sleep
; 45(3)2022 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34480579
14.
Transition from Syringe to Autoinjector Based on Bridging Pharmacokinetics and Pharmacodynamics of the P2Y12 Receptor Antagonist Selatogrel in Healthy Subjects.
Clin Pharmacokinet
; 61(5): 687-695, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34961905
15.
Assessment of the effect of the dual orexin receptor antagonist daridorexant on various indices of disease severity in patients with mild to moderate obstructive sleep apnea.
Sleep Med
; 92: 4-11, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35306405
16.
Impact of ABCC2 genotype on antiepileptic drug response in Caucasian patients with childhood epilepsy.
Pharmacogenet Genomics
; 21(10): 624-30, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21799461
17.
Pharmacokinetics and Pharmacodynamics of Cenerimod, A Selective S1P1 R Modulator, Are Not Affected by Ethnicity in Healthy Asian and White Subjects.
Clin Transl Sci
; 14(1): 143-147, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32860737
18.
Effect of the new dual orexin receptor antagonist daridorexant on nighttime respiratory function and sleep in patients with mild and moderate obstructive sleep apnea.
Sleep
; 44(6)2021 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33305817
19.
Impact of Daridorexant, a Dual Orexin Receptor Antagonist, on Cardiac Repolarization Following Bedtime Dosing: Results from a Thorough QT Study Using Concentration-QT Analysis.
Clin Drug Investig
; 41(8): 711-721, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34331678
20.
Insights from In Vitro and Clinical Data to Guide Transition from the Novel P2Y12 Antagonist Selatogrel to Clopidogrel, Prasugrel, and Ticagrelor.
Thromb Haemost
; 121(6): 755-766, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33412611