Detalhe da pesquisa
1.
Pharmacological Induction of a Progenitor State for the Efficient Expansion of Primary Human Hepatocytes.
Hepatology
; 69(5): 2214-2231, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30549291
2.
Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency.
Genome Res
; 24(8): 1251-9, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24879558
3.
Helper-dependent adenoviral liver gene therapy protects against induced attacks and corrects protein folding stress in acute intermittent porphyria mice.
Hum Mol Genet
; 22(14): 2929-40, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23562909
4.
Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation.
Nat Commun
; 15(1): 1876, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38485924
5.
Gene therapy for liver diseases - progress and challenges.
Nat Rev Gastroenterol Hepatol
; 20(5): 288-305, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36646909
6.
High-efficiency purification of divergent AAV serotypes using AAVX affinity chromatography.
Mol Ther Methods Clin Dev
; 28: 146-159, 2023 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36654797
7.
Understanding and Tackling Immune Responses to Adeno-Associated Viral Vectors.
Hum Gene Ther
; 34(17-18): 836-852, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37672519
8.
Topoisomerase Inhibitors Increase Episomal DNA Expression by Inducing the Integration of Episomal DNA in Hepatic Cells.
Pharmaceutics
; 15(10)2023 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37896219
9.
Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates.
J Transl Med
; 10: 122, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22704060
10.
Sustained enzymatic correction by rAAV-mediated liver gene therapy protects against induced motor neuropathy in acute porphyria mice.
Mol Ther
; 19(2): 243-50, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20877347
11.
Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate.
Nat Commun
; 13(1): 1359, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35292639
12.
Ancestral library identifies conserved reprogrammable liver motif on AAV capsid.
Cell Rep Med
; 3(11): 100803, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36327973
13.
Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates.
Mol Ther
; 18(4): 754-65, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20087317
14.
Porphobilinogen deaminase over-expression in hepatocytes, but not in erythrocytes, prevents accumulation of toxic porphyrin precursors in a mouse model of acute intermittent porphyria.
J Hepatol
; 52(3): 417-24, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19815305
15.
Human Hepatocyte-Derived Induced Pluripotent Stem Cells: MYC Expression, Similarities to Human Germ Cell Tumors, and Safety Issues.
Stem Cells Int
; 2016: 4370142, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26880963
16.
Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus.
PLoS One
; 9(1): e85432, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24465560
17.
Safety and liver transduction efficacy of rAAV5-cohPBGD in nonhuman primates: a potential therapy for acute intermittent porphyria.
Hum Gene Ther
; 24(12): 1007-17, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24070415
18.
Renal failure affects the enzymatic activities of the three first steps in hepatic heme biosynthesis in the acute intermittent porphyria mouse.
PLoS One
; 7(3): e32978, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22412963