[Morphofunctional status of the lungs in extrinsic allergic alveolitis]. / Morfofunktsional'noe sostoianie legkikh pri ékzogennom allergicheskom al'veolite.

Morphological changes in the lungs of 57 patients suffering from exogenous allergic alveolitis (EAA) are described, the majority of patients had a contact with birds. Interstitial edema, microcirculation disturbances and abundant lymphoid infiltration were observed at an acute initial stage of the disease in 5 patients. Sarcoid-like granulomas in the lung interstitium and bronchiolar wall were found at a subacute stage of the disease in 10 patients along with edema, microcirculatory disturbances and lymphoid infiltration. Predomination of fibrosis with a deformation of all lung structures were observed in 42 patients with a chronic course of the disease.

[Thanatogenesis of pulmonary tuberculosis based on statistics from tuberculosis hospitals in Moscow]. / Tanatogenez tuberkuleza legkikh po materialam tuberkuleznykh bolnits Moskvy.

Thanatogenesis of pulmonary tuberculosis has been studied on autopsy material gained in tuberculosis hospitals of Moscow from 1972 to 1992. The leading cause of lethal outcomes was progressive fibrous-cavernous tuberculosis (71.6% in 1992). Disseminated tuberculosis mortality rose two-fold (14.2% in 1992). Death rate for infiltrative tuberculosis reaches now 5.56%. Tuberculous patients die of the progressive disease in 54.94%, of respiratory distress and cardiac insufficiency in 32.72%. Progressive tuberculosis proved to combine with nontuberculous diseases in 71.87% of the cases.

[An experimental study of the chemotherapeutic efficacy of flurenizid, a new antitubercular pharmaceutical]. / Khimioterapevticheskaia éffektivnost' novogo protivotuberkuleznogo farmakologicheskogo sredstva flurenizida v éksperimente.

The efficacy of a chemotherapeutic effect of flurenizid, a new antituberculous drug, was experimentally demonstrated. Flurenizid is an aromatic heterocyclic derivative. As estimated on the models of hematogenic disseminated and destructive pulmonary tuberculosis, a chemotherapeutic dose of the drug was 20 and 50 mg per kg body weight of an animal. Phagocytotic stimulation and fibrillogenetic intensification represent one of the mechanisms of its action. The most pronounced efficacy of flurenizid was noted when it was combined with isoniazid.

[The pathoanatomical,diagnosis of progressive forms of pulmonary tuberculosis in relation to the new clinical classification]. / Patologoanatomicheskaia diagnostika progressiruiushchikh form tuberkuleza legkikh v sviazi s novoi klinicheskoi klassifikatsiei.

This communication is a letter of information that gives for postmortem diagnosis a brief account of tuberculous inflammation and major types of pulmonary tuberculosis during their progression to death and an approximate outline of pathoanatomical diagnosis. Terminal tuberculosis is shown to be now complicated by miliary and caseous pneumonias. Caseous pneumonia may appear as an independent nosological entity and as a complication of acute progression, more frequently, of fibrocavernous tuberculosis. Caseous pneumonia as a tuberculosis type is an irreversible process that calls for emergency surgical treatment. It has been found that there are primarily impairments in lung connective tissue function, acute mesenchymopathy with high blood barrier permeability in caseous pneumonia. Terminal bronchiolar lesion is a later stage in the pathogenesis of caseous pneumonia.

[Tuberculosis thanatogenesis and pathoanatomy of caseous pneumonia]. / Tanatogenez tuberkuleza i patologicheskaia anatomiia kazeoznoi pnevmonii.

Tuberculosis thanatogenesis of today has been studied on autopsy and operative material. Pathoanatomy and mechanism of development of caseous pneumonia have been investigated: types of tissue reactions and role of terminal and respiratory bronchioles in the development of caseous pneumonia are shown and early phases of pathological changes of the connective tissue and interstitium (acute mesenchymopathy) distinguished. Caseous pneumonia has been distinguished for the first time. Its reversible phase may be cured by modern treatment strategy, whereas in its irreversible form not only conservative, but urgent surgical treatment is indicated.