Detalhe da pesquisa
1.
Using conformational constraints at position 6 of Angiotensin II to generate compounds with enhanced AT2R selectivity and proteolytic stability.
Bioorg Med Chem Lett
; 43: 128086, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33965531
2.
Indoloazepinone-Constrained Oligomers as Cell-Penetrating and Blood-Brain-Barrier-Permeating Compounds.
Chembiochem
; 19(7): 696-705, 2018 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29377388
3.
Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases.
Chemistry
; 22(39): 14022-14028, 2016 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27515561
4.
Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
J Med Chem
; 67(4): 2690-2711, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38345933
5.
3-Substituted 2-isocyanopyridines as versatile convertible isocyanides for peptidomimetic design.
Chem Commun (Camb)
; 57(56): 6863-6866, 2021 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34132258
6.
Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure.
J Med Chem
; 64(1): 357-369, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33190475
7.
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.
Sci Adv
; 5(11): eaax9115, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31807708
8.
χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.
ACS Med Chem Lett
; 8(11): 1177-1182, 2017 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29152051
9.
Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design.
J Med Chem
; 59(24): 10865-10890, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27690430
10.
T3P-Promoted, Mild, One-Pot Syntheses of Constrained Polycyclic Lactam Dipeptide Analogues via Stereoselective Pictet-Spengler and Meyers Lactamization Reactions.
Org Lett
; 17(18): 4482-5, 2015 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26322913
11.
Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist.
ACS Med Chem Lett
; 6(2): 192-7, 2015 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25699148
12.
Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.
Eur J Med Chem
; 92: 64-77, 2015 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25544687