Pesquisa | Biblioteca Virtual em Saúde

1.

A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG^™ cell line as a rapid and reliable tool for improved in vitro hazard assessment.

Ates, Gamze; Mertens, Birgit; Heymans, Anja; Verschaeve, Luc; Milushev, Dimiter; Vanparys, Philippe; Roosens, Nancy H C; De Keersmaecker, Sigrid C J; Rogiers, Vera; Doktorova, Tatyana Y.

Arch Toxicol ; 92(4): 1593-1608, 2018 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-29411056

2.

In silico tools and transcriptomics analyses in the mutagenicity assessment of cosmetic ingredients: a proof-of-principle on how to add weight to the evidence.

Ates, Gamze; Raitano, Giuseppa; Heymans, Anja; Van Bossuyt, Melissa; Vanparys, Philippe; Mertens, Birgit; Chesne, Christophe; Roncaglioni, Alessandra; Milushev, Dimiter; Benfenati, Emilio; Rogiers, Vera; Doktorova, Tatyana Y.

Mutagenesis ; 31(4): 453-61, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-26980085

3.

Interlaboratory validation of the ToxTracker assay: An in vitro reporter assay for mechanistic genotoxicity assessment.

Hendriks, Giel; Adriaens, Els; Allemang, Ashley; Clements, Julie; Cole, Gabrielle; Derr, Remco; Engel, Maria; Hamel, Annie; Kidd, Darren; Kellum, Stephanie; Kiyota, Tomomi; Myhre, Abby; Naëssens, Valerie; Pfuhler, Stefan; Roy, Marise; Settivari, Raja; Schuler, Maik; Zeller, Andreas; van Benthem, Jan; Vanparys, Philippe; Kirkland, David.

Environ Mol Mutagen ; 65(1-2): 4-24, 2024.

Artigo em Inglês | MEDLINE | ID: mdl-38545858

4.

Application of in vitro cell transformation assays in regulatory toxicology for pharmaceuticals, chemicals, food products and cosmetics.

Vanparys, Philippe; Corvi, Raffaella; Aardema, Marilyn J; Gribaldo, Laura; Hayashi, Makoto; Hoffmann, Sebastian; Schechtman, Leonard.

Mutat Res ; 744(1): 111-6, 2012 Apr 11.

Artigo em Inglês | MEDLINE | ID: mdl-22342612

5.

ECVAM prevalidation study on in vitro cell transformation assays: general outline and conclusions of the study.

Corvi, Raffaella; Aardema, Marilyn J; Gribaldo, Laura; Hayashi, Makoto; Hoffmann, Sebastian; Schechtman, Leonard; Vanparys, Philippe.

Mutat Res ; 744(1): 12-9, 2012 Apr 11.

Artigo em Inglês | MEDLINE | ID: mdl-22138617

6.

Regulatory assessment of in vitro skin corrosion and irritation data within the European framework: Workshop recommendations.

Eskes, Chantra; Detappe, Véronique; Koëter, Herman; Kreysa, Joachim; Liebsch, Manfred; Zuang, Valérie; Amcoff, Patric; Barroso, João; Cotovio, José; Guest, Robert; Hermann, Martina; Hoffmann, Sebastian; Masson, Philippe; Alépée, Nathalie; Arce, Luis Alfonso; Brüschweiler, Beat; Catone, Tiziana; Cihak, Rostislav; Clouzeau, Jack; D'Abrosca, Federica; Delveaux, Cédric; Derouette, Jean Paul; Engelking, Oliver; Facchini, Davide; Fröhlicher, Mirjam; Hofmann, Markus; Hopf, Nancy; Molinari, Jennifer; Oberli, Aurelia; Ott, Matthieu; Peter, Ronald; Sá-Rocha, Vanessa M; Schenk, Dominique; Tomicic, Catherine; Vanparys, Philippe; Verdon, Bernadette; Wallenhorst, Thomas; Winkler, Gian Christian; Depallens, Olivier.

Regul Toxicol Pharmacol ; 62(2): 393-403, 2012 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-22085589

7.

A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins.

Kirkland, David; Reeve, Lesley; Gatehouse, David; Vanparys, Philippe.

Mutat Res ; 721(1): 27-73, 2011 Mar 18.

Artigo em Inglês | MEDLINE | ID: mdl-21238603

8.

Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop.

Pfuhler, Stefan; Kirkland, David; Kasper, Peter; Hayashi, Makoto; Vanparys, Philippe; Carmichael, Paul; Dertinger, Stephen; Eastmond, David; Elhajouji, Azeddine; Krul, Cyrille; Rothfuss, Andreas; Schoening, Gabriele; Smith, Andrew; Speit, Guenter; Thomas, Claire; van Benthem, Jan; Corvi, Raffaella.

Mutat Res ; 680(1-2): 31-42, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19765670

9.

ECVAM retrospective validation of in vitro micronucleus test (MNT).

Corvi, Raffaella; Albertini, Silvio; Hartung, Thomas; Hoffmann, Sebastian; Maurici, Daniela; Pfuhler, Stefan; van Benthem, Jan; Vanparys, Philippe.

Mutagenesis ; 23(4): 271-83, 2008 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-18326866

10.

Automated analysis of contractility in the embryonic stem cell test, a novel approach to assess embryotoxicity.

Peters, Annelieke K; Wouwer, Gert Van de; Weyn, Barbara; Verheyen, Geert R; Vanparys, Philippe; Gompel, Jacques Van.

Toxicol In Vitro ; 22(8): 1948-56, 2008 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-18845236

11.

Optimisation of the cell cultivation methods in the embryonic stem cell test results in an increased differentiation potential of the cells into strong beating myocard cells.

De Smedt, Ann; Steemans, Margino; De Boeck, Marlies; Peters, Annelieke K; van der Leede, Bas-jan; Van Goethem, Freddy; Lampo, Ann; Vanparys, Philippe.

Toxicol In Vitro ; 22(7): 1789-96, 2008 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-18672049

12.

State of the art in developmental toxicity screening methods and a way forward: a meeting report addressing embryonic stem cells, whole embryo culture, and zebrafish.

Chapin, Robert; Augustine-Rauch, Karen; Beyer, Bruce; Daston, George; Finnell, Richard; Flynn, Thomas; Hunter, Sidney; Mirkes, Phillip; O'Shea, K Sue; Piersma, Aldert; Sandler, David; Vanparys, Philippe; Van Maele-Fabry, Geneviève.

Birth Defects Res B Dev Reprod Toxicol ; 83(4): 446-56, 2008 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-18702117

13.

International prevalidation study on cell transformation assay. Preface.

Corvi, Raffaella; Vanparys, Philippe.

Mutat Res ; 744(1): 1-2, 2012 Apr 11.

Artigo em Inglês | MEDLINE | ID: mdl-22387843

14.

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.

Kirkland, David; Pfuhler, Stefan; Tweats, David; Aardema, Marilyn; Corvi, Raffaella; Darroudi, Firouz; Elhajouji, Azeddine; Glatt, Hansruedi; Hastwell, Paul; Hayashi, Makoto; Kasper, Peter; Kirchner, Stephan; Lynch, Anthony; Marzin, Daniel; Maurici, Daniela; Meunier, Jean-Roc; Müller, Lutz; Nohynek, Gerhard; Parry, James; Parry, Elizabeth; Thybaud, Veronique; Tice, Ray; van Benthem, Jan; Vanparys, Philippe; White, Paul.

Mutat Res ; 628(1): 31-55, 2007 Mar 30.

Artigo em Inglês | MEDLINE | ID: mdl-17293159

15.

Flow cytometric analysis of micronucleated reticulocytes: Time- and dose-dependent response of known mutagens in mice, using multiple blood sampling.

De Boeck, Marlies; van der Leede, Bas-jan; Van Goethem, Freddy; De Smedt, Ann; Steemans, Margino; Lampo, Ann; Vanparys, Philippe.

Environ Mol Mutagen ; 46(1): 30-42, 2005 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-15880423

16.

Interlaboratory validation of a CD71-based flow cytometric method (Microflow) for the scoring of micronucleated reticulocytes in mouse peripheral blood.

Torous, Dorothea K; Hall, Nikki E; Illi-Love, Anne H; Diehl, Marilyn S; Cederbrant, Karin; Sandelin, Kerstin; Pontén, Ingrid; Bolcsfoldi, George; Ferguson, Lynnette R; Pearson, Amira; Majeska, Jenness B; Tarca, James P; Hynes, Geoffrey M; Lynch, Anthony M; McNamee, James P; Bellier, Pascale V; Parenteau, Monique; Blakey, David; Bayley, Janet; van der Leede, Bas-Jan M; Vanparys, Philippe; Harbach, Philip R; Zhao, Shuou; Filipunas, Anthony L; Johnson, Carol W; Tometsko, Carol R; Dertinger, Stephen D.

Environ Mol Mutagen ; 45(1): 44-55, 2005.

Artigo em Inglês | MEDLINE | ID: mdl-15605355

17.

ECVAM and pharmaceuticals.

Vanparys, Philippe.

Altern Lab Anim ; 30 Suppl 2: 221-3, 2002 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-12513680

18.

A review of the implementation of the embryonic stem cell test (EST). The report and recommendations of an ECVAM/ReProTect Workshop.

Marx-Stoelting, Philip; Adriaens, Els; Ahr, Hans-Jürgen; Bremer, Susanne; Garthoff, Bernward; Gelbke, Heinz-Peter; Piersma, Aldert; Pellizzer, Cristian; Reuter, Ulrike; Rogiers, Vera; Schenk, Barbara; Schwengberg, Silke; Seiler, Andrea; Spielmann, Horst; Steemans, Margino; Stedman, Donald B; Vanparys, Philippe; Vericat, Joan Albert; Verwei, Miriam; van der Water, Femke; Weimer, Marc; Schwarz, Michael.

Altern Lab Anim ; 37(3): 313-28, 2009 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-19678733

19.

Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop.

Kirkland, David; Zeiger, Errol; Madia, Federica; Gooderham, Nigel; Kasper, Peter; Lynch, Anthony; Morita, Takeshi; Ouedraogo, Gladys; Parra Morte, Juan Manuel; Pfuhler, Stefan; Rogiers, Vera; Schulz, Markus; Thybaud, Veronique; van Benthem, Jan; Vanparys, Philippe; Worth, Andrew; Corvi, Raffaella.

Mutat Res Genet Toxicol Environ Mutagen ; 775-776: 55-68, 2014 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-25435356

20.

Improvement of the Bovine Corneal Opacity and Permeability (BCOP) assay as an in vitro alternative to the Draize rabbit eye irritation test.

Verstraelen, Sandra; Jacobs, An; De Wever, Bart; Vanparys, Philippe.

Toxicol In Vitro ; 27(4): 1298-311, 2013 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-23501624

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