RESUMO
BACKGROUND: The globally synchronized switch from trivalent Oral Polio Vaccine (tOPV) to bivalent Oral Polio Vaccine (bOPV) took place in Nigeria on April 18th 2016. The country is divided into six geopolitical zones. This study reports the experiences and lessons learned from the switch process in the six states that make up Nigeria's south-south geopolitical zone. METHODS: This was a descriptive retrospective review of Nigeria's switch plan and structures used for implementing the tOPV-bOPV switch in the south-south zone. Nigeria's National Polio Emergency Operation Centre (NPEOC) protocols, global guidelines and reports from switch supervisors during the switch were used to provide background information for this study. Quantitative data were derived from reviewing switch monitoring and validation documents as submitted to the NPEOC RESULTS: The switch process took place in all 3078 Health Facilities (HFs) and 123 Local Government Areas (LGAs) that make up the six states in the zone. A total of $139,430 was used for this process. The 'healthcare personnel' component received the highest budgetary allocation (59%) followed by the 'logistics' component (18%). Akwa Ibom state was allocated the highest number of healthcare personnel and hence received the most budgetary allocation compared to the six states (total healthcare personnel = 458, total budgetary allocation = $17,428). Validation of the switch process revealed that eight HFs in Bayelsa, Cross-River, Edo and Rivers states still possessed tOPV in cold-chain while six HFs in Cross-River and Rivers states had tOPV out of cold-chain but without the 'do not use' sticker. Akwa-Ibom was the only state in the zone to have bOPV and Inactivated Polio Vaccine (IPV) available in all its HFs monitored. CONCLUSION: The Nigerian tOPV-bOPV switch was successful. For future Oral Polio Vaccine (OPV) withdrawals, implementation of the switch plan would be more feasible with an earlier dissemination of funds from global donor organizations, which would greatly aid timely planning and preparations. Increased budgetary allocation to the 'logistics' component to accommodate unexpected hikes in transportation prices and the general inefficiencies with power supply in the country is also advised.
Assuntos
Poliomielite/prevenção & controle , Vacina Antipólio Oral/imunologia , Vacinação/métodos , Humanos , Nigéria , Vacina Antipólio Oral/economia , Estudos RetrospectivosRESUMO
BACKGROUND: The tremendous progress made by Nigeria towards polio eradication has recently suffered a setback with the isolation of circulating vaccine-derived poliovirus (cVDPV) type 2 from environmental samples and confirmation of four wild poliovirus (WPV) cases from acute flaccid paralysis (AFP) cases, with dates of onset of paralysis in July and August 2016. All these viruses were confirmed from the security-challenged northeastern state of Borno. Polio-compatible cases exist in Nigeria, and they indicate surveillance failure. Surveillance, therefore, has to be strengthened for the country to achieve certification. The objective of this paper is to highlight the epidemiological profile and magnitude of polio-compatible cases in Nigeria during the reporting period, as well as immunization and surveillance response activities conducted to close immunity and surveillance gaps. METHODS: We conducted a retrospective review of AFP surveillance performance and polio-compatible cases in Nigeria between 2006 and 2016 from the AFP database at the World Health Organization Country Office. We also reviewed and compared key epidemiological features of polio-compatible cases with those of wild poliovirus cases during the reporting period. RESULTS: The non-polio AFP rate improved from 6.5 in 2006 to 19.5 in 2016. The corresponding figures for stool adequacy rates were 88 and 98%. The total number of polio-compatible cases reported during the reporting period was 888, with the highest number (194) of cases reported in 2006 and the least (24) in 2016. Clusters of polio-compatible cases were reported every year during the reporting period except in 2015. The highest number (65) of polio-compatible cases in clusters was reported in 2006. The key epidemiological features of polio-compatible and wild poliovirus cases were similar. CONCLUSION: AFP surveillance performance has improved significantly during the reporting period. Surveillance gaps still existed as shown by the presence of orphan viruses and polio-compatible cases, and these gaps need to be identified and closed to achieve certification.
Assuntos
Poliomielite/epidemiologia , Vigilância da População , Criança , Humanos , Nigéria/epidemiologia , Estudos RetrospectivosRESUMO
In 2014, inactivated poliovirus vaccine (IPV) campaigns were implemented in Nigeria and Pakistan after clinical trials showed that IPV boosts intestinal immunity in children previously given oral poliovirus vaccine (OPV). We estimated the effect of these campaigns by using surveillance data collected during January 2014-April 2016. In Nigeria, campaigns with IPV and trivalent OPV (tOPV) substantially reduced the incidence of poliomyelitis caused by circulating serotype-2 vaccine-derived poliovirus (incidence rate ratio [IRR] 0.17 for 90 days after vs. 90 days before campaigns, 95% CI 0.04-0.78) and the prevalence of virus in environmental samples (prevalence ratio [PR] 0.16, 95% CI 0.02-1.33). Campaigns with tOPV alone resulted in similar reductions (IRR 0.59, 95% CI 0.18-1.97; PR 0.45, 95% CI 0.21-0.95). In Pakistan, the effect of IPV+tOPV campaigns on wild-type poliovirus was not significant. Results suggest that administration of IPV alongside OPV can decrease poliovirus transmission if high vaccine coverage is achieved.
Assuntos
Poliomielite/epidemiologia , Poliomielite/prevenção & controle , Vacina Antipólio de Vírus Inativado/imunologia , Poliovirus/imunologia , Feminino , Geografia Médica , História do Século XXI , Humanos , Programas de Imunização , Incidência , Masculino , Nigéria/epidemiologia , Avaliação de Resultados em Cuidados de Saúde , Paquistão/epidemiologia , Poliomielite/história , Vacina Antipólio de Vírus Inativado/administração & dosagem , Prevalência , VacinaçãoRESUMO
BACKGROUND: Global withdrawal of serotype-2 oral poliovirus vaccine (OPV2) took place in April 2016. This marked a milestone in global polio eradication and was a public health intervention of unprecedented scale, affecting 155 countries. Achieving high levels of serotype-2 population immunity before OPV2 withdrawal was critical to avoid subsequent outbreaks of serotype-2 vaccine-derived polioviruses (VDPV2s). METHODS AND FINDINGS: In August 2015, we estimated vaccine-induced population immunity against serotype-2 poliomyelitis for 1 January 2004-30 June 2015 and produced forecasts for April 2016 by district in Nigeria and Pakistan. Population immunity was estimated from the vaccination histories of children <36 mo old identified with non-polio acute flaccid paralysis (AFP) reported through polio surveillance, information on immunisation activities with different oral poliovirus vaccine (OPV) formulations, and serotype-specific estimates of the efficacy of these OPVs against poliomyelitis. District immunity estimates were spatio-temporally smoothed using a Bayesian hierarchical framework. Coverage estimates for immunisation activities were also obtained, allowing for heterogeneity within and among districts. Forward projections of immunity, based on these estimates and planned immunisation activities, were produced through to April 2016 using a cohort model. Estimated population immunity was negatively correlated with the probability of VDPV2 poliomyelitis being reported in a district. In Nigeria and Pakistan, declines in immunity during 2008-2009 and 2012-2013, respectively, were associated with outbreaks of VDPV2. Immunity has since improved in both countries as a result of increased use of trivalent OPV, and projections generally indicated sustained or improved immunity in April 2016, such that the majority of districts (99% [95% uncertainty interval 97%-100%] in Nigeria and 84% [95% uncertainty interval 77%-91%] in Pakistan) had >70% population immunity among children <36 mo old. Districts with lower immunity were clustered in northeastern Nigeria and northwestern Pakistan. The accuracy of immunity estimates was limited by the small numbers of non-polio AFP cases in some districts, which was reflected by large uncertainty intervals. Forecasted improvements in immunity for April 2016 were robust to the uncertainty in estimates of baseline immunity (January-June 2015), vaccine coverage, and vaccine efficacy. CONCLUSIONS: Immunity against serotype-2 poliomyelitis was forecasted to improve in April 2016 compared to the first half of 2015 in Nigeria and Pakistan. These analyses informed the endorsement of OPV2 withdrawal in April 2016 by the WHO Strategic Advisory Group of Experts on Immunization.
Assuntos
Poliomielite/prevenção & controle , Vacina Antipólio Oral/administração & dosagem , Pré-Escolar , Erradicação de Doenças , Revisão de Uso de Medicamentos , Saúde Global , Humanos , Imunidade , Incidência , Lactente , Poliomielite/epidemiologia , Poliovirus/classificação , Poliovirus/imunologia , SorotipagemRESUMO
OBJECTIVES: Despite the availability of vaccines, children are the people most often affected by epidemic meningococcal meningitis. The pattern of the epidemic meningococcal meningitis outbreak in Northern Nigeria in 2009 and the Neisseria meningitidis strains responsible for this epidemic are described here. METHODS: A retrospective cross-sectional study was conducted in 16 states, involving 48 local government areas (LGAs), 91 health facilities, and 96 communities. Data collection involved in-depth interviews with key informants from the federal to the community level, a review of records, and a solution-oriented national workshop with participants from all states of the Federation. Cerebrospinal fluid (CSF) samples were collected from some of the suspected cases at the start of the outbreak and were tested using the rapid Pastorex latex agglutination kit. RESULTS: Kastina (11153, 20.4%), Jigawa (8643, 15.8%), Bauchi (8463, 15.5%), Kano (6811, 12.4%), and Gombe (6110, 11.2%) were the states with the highest prevalence of meningitis. The states of Nasarawa (11.0%), Adamawa (8.0%), and Borno (7.6%) recorded the highest percentage of deaths, while the Shongom (Gombe State 12.5%), Illela (Sokoto State 9.8%), and Ikara (Kaduna State 9.1%) LGAs recorded the most deaths amongst cases seen. CONCLUSIONS: The testing of CSF samples during meningitis outbreaks is recommended in order to monitor the occurrence of the multiple meningitis serotypes during these outbreaks and to direct serotype-specific vaccination response activities.
Assuntos
Surtos de Doenças , Epidemias , Meningite Meningocócica/epidemiologia , Vacinas Meningocócicas/administração & dosagem , Neisseria meningitidis/imunologia , Vacinação , Testes de Aglutinação , Estudos Transversais , Humanos , Meningite Meningocócica/mortalidade , Neisseria meningitidis/isolamento & purificação , Nigéria/epidemiologia , Estudos Retrospectivos , Risco , SorogrupoRESUMO
OBJECTIVE: To determine the laboratory-based performance and operational characteristics of three dual rapid diagnostic tests (RDTs) for testing HIV and syphilis. METHODS: Three dual RDTs (SD Bioline, Chembio, and MedMira) were evaluated using 1514 serum specimens archived at laboratories or collected from clinics in China and Nigeria to determine sensitivity and specificity, with 95% confidence intervals. Concordance of testing results read by two technicians, stability of testing results read at two time points, and test operation characteristics were also assessed. RESULTS: All three of the evaluated RDTs gave excellent performance with a combined sensitivity ranging from 99.0%-99.6% for HIV and 98.3%-99.0% for syphilis, and a combined specificity ranging from 97.9%-99.0% for HIV and 97.2%-99.6% for syphilis. Concordance of testing results between two technicians and stability of testing results read within and one hour past the recommended reading period showed excellent agreement, with Kappa greater than or equal to 0.98. CONCLUSIONS: All the tests were found to be very or fairly easy to use and easy to interpret the results. Further evaluations of these dual RDTs with whole blood in field settings, and more studies on the implication of introduction of these tests in HIV and syphilis control programs are needed.
Assuntos
Sorodiagnóstico da AIDS/instrumentação , Infecções por HIV/diagnóstico , Kit de Reagentes para Diagnóstico , Sorodiagnóstico da Sífilis/instrumentação , Sífilis/diagnóstico , Sorodiagnóstico da AIDS/métodos , Sorodiagnóstico da AIDS/estatística & dados numéricos , China , Feminino , Humanos , Nigéria , Testes Imediatos , Gravidez , Diagnóstico Pré-Natal/instrumentação , Diagnóstico Pré-Natal/métodos , Diagnóstico Pré-Natal/estatística & dados numéricos , Sensibilidade e Especificidade , Sorodiagnóstico da Sífilis/métodos , Sorodiagnóstico da Sífilis/estatística & dados numéricosRESUMO
In 2005; the WHO Regional Committee for Africa called upon countries to accelerate HIV prevention and to declare 2006 as the Year of Acceleration of HIV Prevention in the African Region. The strategy document that was developed by WHO Regional Office was adopted by the Region's ministers of health in August 2006. The strategy proposed targets to be met by 2010; in line with universal access targets; in areas of HIV testing and counselling; prevention of mother-to-child transmission of HIV; prevention and control of sexually-transmitted infections; blood safety; and access to comprehensive prevention; treatment and care. Specifically; it was envisaged that; by 2010; all districts will provide HIV testing and counselling services; 100100 safe blood and blood products will be ensured; at least 80of pregnant women attending antenatal care will access prevention of mother-to-child transmission of HIV services; at least 80of patients with sexually-transmitted infections will access comprehensive STI management; at least 80of people living with HIV/AIDS will have access to comprehensive prevention; treatment and care services; and condom use in high-risk sexual encounters will reach at least 60. This paper describes the progress made in accelerating key health sector HIV prevention interventions in the Region toward these targets and issues that should be taken into consideration for moving forward the HIV prevention agenda in the health sector
Assuntos
África , Antirretrovirais , Segurança do Sangue , Infecções por HIV , Setor de Assistência à Saúde , Acessibilidade aos Serviços de Saúde , Transmissão Vertical de Doenças Infecciosas , Programas Nacionais de Saúde , Organização Mundial da SaúdeRESUMO
Para determinar a prevalência, identificar os comportamentos de risco e os níveis de informaçäo sobre a esquistossomose urinária, realizou-se um estudo transversal, entre outubro e novembro de 1996, em três escolas primárias da Area de Saúde 1§ de Junho, na cidade de Maputo, Moçambique. Efetuaram-se inquéritos epidemiológicos e recolheram-se amostras únicas de urina de 434 escolares de ambos os sexos, selecionados ao acaso, da segunda a quinta classes. A idade média foi de 11,3 anos (amplitude 6-16). A prevalência encontrada foi de 11,3 por cento (49/434). O grupo etário de 15 e mais anos apresentou a prevalência mais elevada (13,6 por cento), enquanto o de 10 a 14 anos, a maior intensidade de infecçäo (204 ovos/10 ml de urina). Apenas 18,9 por cento dos escolares já tinham ouvido falar na doença. Destes, só 19,5 por cento (16/82) sabiam como esta se manifestava. Cerca de 50 por cento dos escolares reportaram contatos freqüentes com potenciais focos de transmissäo de esquistossomose. Os resultados sugerem que a esquistossomose urinária é um problema de saúde pública nas escolas da Area de Saúde 1§ de Junho.
Assuntos
Humanos , Esquistossomose Urinária/epidemiologia , Estudantes , Prevalência , Assunção de RiscosRESUMO
Para determinar a prevalência, identificar os comportamentos de risco e os níveis de informaçäo sobre a esquistossomose urinária, realizou-se um estudo transversal, entre outubro e novembro de 1996, em três escolas primárias da Area de Saúde 1§ de Junho, na cidade de Maputo, Moçambique. Efetuaram-se inquéritos epidemiológicos e recolheram-se amostras únicas de urina de 434 escolares de ambos os sexos, selecionados ao acaso, da segunda a quinta classes. A idade média foi de 11,3 anos (amplitude 6-16). A prevalência encontrada foi de 11,3 por cento (49/434). O grupo etário de 15 e mais anos apresentou a prevalência mais elevada (13,6 por cento), enquanto o de 10 a 14 anos, a maior intensidade de infecçäo (204 ovos/10 ml de urina). Apenas 18,9 por cento dos escolares já tinham ouvido falar na doença. Destes, só 19,5 por cento (16/82) sabiam como esta se manifestava. Cerca de 50 por cento dos escolares reportaram contatos freqüentes com potenciais focos de transmissäo de esquistossomose. Os resultados sugerem que a esquistossomose urinária é um problema de saúde pública nas escolas da Area de Saúde 1§ de Junho.(AU)
Assuntos
Humanos , Esquistossomose Urinária/epidemiologia , Estudantes , Prevalência , Assunção de RiscosRESUMO
Para determinar a prevalência, identificar os comportamentos de risco e os níveis de informação sobre a esquistossomose urinária, realizou-se um estudo transversal, entre outubro e novembro de 1996, em três escolas primárias da Área de Saúde 1º de Junho, na cidade de Maputo, Moçambique. Efetuaram-se inquéritos epidemiológicos e recolheram-se amostras únicas de urina de 434 escolares de ambos os sexos, selecionados ao acaso, da segunda a quinta classes. A idade média foi de 11,3 anos (amplitude 6-16). A prevalência encontrada foi de 11,3% (49/434). O grupo etário de 15 e mais anos apresentou a prevalência mais elevada (13,6%), enquanto o de 10 a 14 anos, a maior intensidade de infecção (204 ovos/10 ml de urina). Apenas 18,9% dos escolares já tinham ouvido falar na doença. Destes, só 19,5% (16/82) sabiam como esta se manifestava. Cerca de 50% dos escolares reportaram contatos freqüentes com potenciais focos de transmissão de esquistossomose. Os resultados sugerem que a esquistossomose urinária é um problema de saúde pública nas escolas da Área de Saúde 1º de Junho
To assess the prevalence and identify levels of information and risk behavior associated with vesical schistosomiasis, a cross-sectional study was conducted in October-November 1996, involving students from 3 primary schools in the Primeiro de Junho health district in Maputo, Mozambique. Epidemiological interviews and urine samples were taken from 434 male and female students from grades 2 through 5, randomly selected. Estimated prevalence was 11.3% (49/434). Highest prevalence was in the age group 15 years old, and the highest intensity of infection among the 10-14-year age group, with 204 eggs/10 ml urine. Approximately 18.9% had heard of schistosomiasis, and of these, only 19.5% (16/82) knew how the disease is manifested. Approximately 50% of the students reported frequent water contacts with potential sources of schistosomiasis. The study shows that vesical schistosomiasis is a public health problem among students in this health district.
Assuntos
Humanos , Criança , Adolescente , Urina , Esquistossomose Urinária , Risco , Inquéritos Epidemiológicos , Transmissão de Doença Infecciosa , Infecções , Assunção de Riscos , Estudantes , Área Programática de Saúde , Saúde , Saúde Pública , Doença , Prevalência , Amplitude de Ondas Sísmicas , Grupos EtáriosRESUMO
Foi realizado um estudo descretivo transversal comparativo em Julho de 1994, abrangendo 379 utentes de quatro Centros de Saúde da Cidade de Maputo, com objetivo de determinar a satisfação de utentes em relação aos cuidados recebidos e factores associados. A satisfação foi analisada em relação aos seguintes indicadores: tempo de espera, trato e cordialidade, compreensão da explicação sobre a doença e tratamento, custo e disponibilidade de medicamentos para o serviço de triagem, farmácia, laboratório de cada centro. A satisfação foi analisada em dois níveis positivo (satisfeito) e negativo (insatisfeito)
A descriptive comparative cross sectional study was carried out in July of 1994, involving 379 users of 4 health centers of Maputo city. The study main objective was to determine the user satisfaction with the services delivered and associated factores. Satisfaction was assessed in respective in respect to the following indicators: waiting time, courtesy, understanding of the illness and treatment, cost and drug availability. These indicators were assessed in the consultation, pharmacy and laboratory units of each Health Centre