Detalhe da pesquisa
1.
Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc Natl Acad Sci U S A
; 120(18): e2216342120, 2023 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37098070
2.
Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors.
Proc Natl Acad Sci U S A
; 112(39): E5381-90, 2015 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26372962
3.
LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition.
Proc Natl Acad Sci U S A
; 109(31): 12509-14, 2012 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22802671
4.
Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin.
PLoS Comput Biol
; 9(7): e1003158, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23874194
5.
Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors.
Chembiochem
; 14(13): 1640-7, 2013 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23956195
6.
LSD1/CoREST reversible opening-closing dynamics: discovery of a nanoscale clamp for chromatin and protein binding.
Biochemistry
; 51(15): 3151-3, 2012 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22468794
7.
Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma.
Biochem Biophys Res Commun
; 426(2): 215-20, 2012 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22935422
8.
Simulation of multiphase systems utilizing independent force fields to control intraphase and interphase behavior.
J Comput Chem
; 33(16): 1458-66, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22488548
9.
SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA.
Blood Cancer Discov
; 2(3): 266-287, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34027418
10.
Assessment of the transferability of a protein force field for the simulation of peptide-surface interactions.
Langmuir
; 26(10): 7396-404, 2010 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20222735
11.
BCR-ABL1 tyrosine kinase inhibitor K0706 exhibits preclinical activity in Philadelphia chromosome-positive leukemia.
Exp Hematol
; 77: 36-40.e2, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31493432
12.
Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants.
Cancer Cell
; 36(4): 431-443.e5, 2019 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31543464
13.
New Strategies in Myeloproliferative Neoplasms: The Evolving Genetic and Therapeutic Landscape.
Clin Cancer Res
; 22(5): 1037-47, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26933174
14.
Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities.
ChemMedChem
; 11(8): 850-61, 2016 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27028877
15.
A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer.
Clin Cancer Res
; 22(10): 2351-8, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26673800
16.
A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties.
Front Pharmacol
; 6: 11, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25713532
17.
Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia.
Leukemia
; 29(3): 586-597, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25134459
18.
Epigenetic molecular recognition: a biomolecular modeling perspective.
ChemMedChem
; 9(3): 484-94, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24616246
19.
BCR-ABL1 compound mutations combining key kinase domain positions confer clinical resistance to ponatinib in Ph chromosome-positive leukemia.
Cancer Cell
; 26(3): 428-442, 2014 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25132497
20.
Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognition.
BMC Biophys
; 6(1): 15, 2013 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24274367