Detalhe da pesquisa
1.
Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors.
Bioorg Med Chem Lett
; 29(4): 659-663, 2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30638874
2.
Discovery of morpholine-based aryl sulfonamides as Nav1.7 inhibitors.
Bioorg Med Chem Lett
; 28(5): 958-962, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29439904
3.
The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.
Bioorg Med Chem Lett
; 28(9): 1550-1557, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29631960
4.
P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.
Bioorg Med Chem Lett
; 28(10): 1853-1859, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29650290
5.
Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.
Antimicrob Agents Chemother
; 60(7): 3956-69, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27090171
6.
Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.
Bioorg Med Chem Lett
; 26(8): 1925-30, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26988305
7.
Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.
J Med Chem
; 65(23): 15935-15966, 2022 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36441509
8.
The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.
J Med Chem
; 65(18): 11927-11948, 2022 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36044257
9.
15N chemical shifts of a series of isatin oxime ethers and their corresponding nitrone isomers.
Magn Reson Chem
; 48(11): 873-6, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20818803
10.
Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo.
Bioorg Med Chem Lett
; 19(16): 4857-62, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19596574
11.
Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).
J Med Chem
; 61(16): 7289-7313, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30067361
12.
Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.
ACS Med Chem Lett
; 7(6): 568-72, 2016 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27326328
13.
Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.
J Med Chem
; 59(17): 8042-60, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27564532
14.
The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.
J Med Chem
; 57(5): 1730-52, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24564672
15.
Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.
J Med Chem
; 57(5): 1708-29, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24555570
16.
Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailability.
Bioorg Med Chem Lett
; 17(4): 895-901, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17169560
17.
Orally active fusion inhibitor of respiratory syncytial virus.
Antimicrob Agents Chemother
; 48(2): 413-22, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14742189
18.
Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease.
Bioorg Med Chem Lett
; 12(21): 3129-33, 2002 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12372517