A case of esophageal squamous cell carcinoma with positive HPV 11.

HPV (human pappiloma virus) infection is an etiologic risk factor for esophageal carcinoma with several studies supporting its carcinogenic role. The main strains are HPV16 and 18 and the less frequent strains 11, 6, 31 and 36. We report the case of a 58 year old male, smoker, admitted to our hospital for progressive dysphagia. Previous endoscopies and biopsies were compatible with a hyperkeratotic esophagus, negative for dysplasia. Second endoscopy showed a hyperkeratotic, verrucous, esophagus with two circumferential stenosis which were dilated with TTS (Through the Scope) balloon. Biopsies revealed multiple squamous cell abnormalities, negative for dysplasia and positive for HPV 11. Symptoms recurred, and he was submitted to another upper gastrointestinal endoscopy with dilation of the stenosis and esophageal stent placement. Two months later, esophagectomy was performed, and the histopathological analysis revealed a squamous cell carcinoma of the esophagus (T2, N0, M0, G1). The patient died after surgery due to acute respiratory distress syndrome.

A case of esophageal complication in epidermolysis bulhosa simplex.

UNLABELLED: It is well known the involvement of the gastrointestinal tract in Epidermolysis Bulhosa (EB) and its consequences on both nutrition and growth. We present a case of a young girl with EB diagnosed soon after birth, admitted to our emergency room with food impactation. The endoscopy revealed a double barrel esophagus. No medical or surgical therapy was started and after 2 months of enteric feeding, spontaneous resolution was observed at endoscopy. Skin biopsy was compatible with EB Simplex. According to the literature EB Simplex is the subtype the least associated with GI tract involvement, presenting with dysphagia in only 2% of the patients, and with the lowest cumulative risk of esophageal stricturing. CONCLUSION: We present an unusual case of EB simplex involvement of the esophagus with spontaneous resolution of a false lumen, with clinical improvement of the patient.

A case of esophageal squamous cell carcinoma with positive HPV 11

La infección por el virus del papiloma humano (VPH) es un factor de riesgo etiológico en el carcinoma esofágico, y varios estudios apoyan su papel cancerígeno. Las cepas más comunes son el VPH 16 y 18 y menos frecuentes VPH 11, 6, 31 y 36. Se presenta el caso de un varón de 58 años, fumador, que ingresó en nuestro hospital por disfagia progresiva. Las endoscopias y biopsias previas eran compatibles con esófago hiperqueratósico y presentaban resultados negativos para displasia. Una segunda endoscopia mostró esófago hiperqueratósico, verrugoso con dos estenosis circunferenciales que fueron dilatadas endoscópicamente con balón TTS (del inglés Through the Scope). Las biopsias revelaron múltiples anormalidades en células escamosas, fueron negativas para displasia y positivas para el VPH 11. Dada la recurrencia de los síntomas, el paciente fue sometido a otra endoscopia de las vías digestivas superiores para realizar dilatación de la estenosis y colocación de endoprótesis esofágica. Dos meses más tarde se llevó a cabo una esofagectomía y el análisis histopatológico reveló carcinoma escamoso de esófago (T2, N0, M0, G1). El paciente falleció después de la cirugía debido a un síndrome agudo de dificultad respiratoria (AU)

HPV (human pappiloma virus) infection is an etiologic risk factor for esophageal carcinoma with several studies supporting its carcinogenic role. The main strains are HPV16 and 18 and the less frequent strains 11, 6, 31 and 36. We report the case of a 58 year old male, smoker, admitted to our hospital for progressive dysphagia. Previous endoscopies and biopsies were compatible with a hyperkeratotic esophagus, negative for dysplasia. Second endoscopy showed a hyperkeratotic, verrucous, esophagus with two circumferential stenosis which were dilated with TTS (Through the Scope) balloon. Biopsies revealed multiple squamous cell abnormalities, negative for dysplasia and positive for HPV 11. Symptoms recurred, and he was submitted to another upper gastrointestinal endoscopy with dilation of the stenosis and esophageal stent placement. Two months later, esophagectomy was performed, and the histopathological analysis revealed a squamous cell carcinoma of the esophagus (T2, N0, M0, G1). The patient died after surgery due to acute respiratory distress syndrome (AU)

A case of esophageal complication in epidermolysis bulhosasimplex

It is well known the involvement of the gastrointestinal tract in Epidermolysis Bulhosa (EB) and its consequences on both nutrition and growth. We present a case of a young girl with EB diagnosed soon after birth, admitted to our emergency room with food impactation. The endoscopy revealed a double barrel esophagus. No medical or surgical therapy was started and after 2 months of enteric feeding, spontaneous resolution was observed at endoscopy. Skinbiopsy was compatible with EB Simplex. According to the literature EB Simplex is the subtype the least associated with GI tract involvement, presenting with dysphagia in only 2% of the patients, and with the lowest cumulative risk of esophageal stricturing. Conclusion: We present an unusual case of EB simplex involvement of the esophagus with spontaneous resolution of a false lumen, with clinical improvement of the patient (AU)

La afectación del tracto gastrointestinal en la epidermólisis ampollosa (EA), y sus consecuencias en la nutrición y el crecimiento, es bien conocida. Se presenta el caso de una niña con diagnóstico de EA poco después del nacimiento que ingresó en nuestro servicio de urgencias con impactación de alimentos. La endoscopia reveló un esófago de doble canal. Sin tratamiento médico ni quirúrgico alguno, y tras 2 meses de alimentación entérica, se observó en la endoscopia la resolución espontánea del problema. La biopsia cutánea era compatible con la EA simple. Según las referencias bibliográficas, la EA simple es el subtipo menos asociado con afectación del tracto gastrointestinal, y solo el 2% de los pacientes presentan disfagia; además, presenta el menor riesgo acumulativo de estenosis esofágica. Conclusión: se presenta un caso de EA simple con afectación inusual del esófago y resolución espontánea de una falsa luz, que condujo a la mejoría clínica de la paciente (AU)