Detalhe da pesquisa
1.
Pharmacological Profile of AZD8871 (LAS191351), a Novel Inhaled Dual M3 Receptor Antagonist/ß 2-Adrenoceptor Agonist Molecule with Long-Lasting Effects and Favorable Safety Profile.
J Pharmacol Exp Ther
; 370(1): 127-136, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31085697
2.
Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /ß2-adrenoceptor agonist (MABA) molecule.
Pulm Pharmacol Ther
; 46: 1-10, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28729041
3.
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists.
Bioorg Med Chem Lett
; 25(8): 1736-1741, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25800115
4.
The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide.
Pulm Pharmacol Ther
; 28(2): 114-21, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24928173
5.
Pharmacological characterization of abediterol, a novel inhaled ß(2)-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical models.
J Pharmacol Exp Ther
; 342(2): 497-509, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22588259
6.
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists.
Bioorg Med Chem Lett
; 22(24): 7672-6, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23141913
7.
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.
Bioorg Med Chem Lett
; 21(11): 3457-61, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21524581
8.
Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile.
J Pharmacol Exp Ther
; 331(2): 740-51, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19710368
9.
Synthesis and structure-activity relationships of gamma-carboline derivatives as potent and selective cysLT(1) antagonists.
Bioorg Med Chem Lett
; 19(15): 4299-302, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19505824
10.
Abediterol (LAS100977), an inhaled long-acting ß2-adrenoceptor agonist, has a fast association rate and long residence time at receptor.
Eur J Pharmacol
; 819: 89-97, 2018 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29183838
11.
4-Amino-7,8-dihydro-1,6-naphthyridin-5(6 H)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure-Activity Relationships.
J Med Chem
; 61(6): 2472-2489, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29502405
12.
Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells.
PLoS One
; 13(1): e0189247, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29320511
13.
In vitro and in vivo preclinical profile of abediterol (LAS100977), an inhaled long-acting ß2-adrenoceptor agonist, compared with indacaterol, olodaterol and vilanterol.
Eur J Pharmacol
; 770: 61-9, 2016 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26656755
14.
Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.
J Med Chem
; 59(23): 10479-10497, 2016 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27933955
15.
Synthesis and structure-activity relationships of novel histamine H1 antagonists: indolylpiperidinyl benzoic acid derivatives.
J Med Chem
; 47(25): 6326-37, 2004 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15566302
16.
Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors.
Eur J Med Chem
; 46(10): 4946-56, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21871695
17.
Synthesis and biological activity of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines as phosphodiesterase type 4 inhibitors.
J Med Chem
; 53(19): 6912-22, 2010 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-20825218
18.
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).
J Med Chem
; 52(16): 5076-92, 2009 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19653626
19.
Synthesis and structure-activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H1 antagonists.
Bioorg Med Chem Lett
; 15(4): 1165-7, 2005 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15686934