Detalhe da pesquisa
1.
Development of a double shmiR lentivirus effectively targeting both BCL11A and ZNF410 for enhanced induction of fetal hemoglobin to treat ß-hemoglobinopathies.
Mol Ther
; 30(8): 2693-2708, 2022 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35526095
2.
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.
Nature
; 527(7577): 192-7, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26375006
3.
Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies.
Br J Haematol
; 180(5): 630-643, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29193029
4.
Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.
Haematologica
; 99(10): 1565-73, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25150253
5.
Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding.
J Biol Chem
; 286(28): 24819-27, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21610079
6.
ZNF410 represses fetal globin by singular control of CHD4.
Nat Genet
; 53(5): 719-728, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33859416
7.
Molecular analysis of the erythroid phenotype of a patient with BCL11A haploinsufficiency.
Blood Adv
; 5(9): 2339-2349, 2021 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33938942
8.
Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits.
Nat Genet
; 52(12): 1333-1345, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33230299
9.
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis.
Nat Genet
; 51(7): 1149-1159, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31253978
10.
Growing and Genetically Manipulating Human Umbilical Cord Blood-Derived Erythroid Progenitor (HUDEP) Cell Lines.
Methods Mol Biol
; 1698: 275-284, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29076097
11.
Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and ß-Globin Expression in Human Fetal Erythroblasts.
PLoS One
; 11(2): e0146802, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26840243