Detalhe da pesquisa
1.
Phage display uncovers a sequence motif that drives polypeptide binding to a conserved regulatory exosite of O-GlcNAc transferase.
Proc Natl Acad Sci U S A
; 120(42): e2303690120, 2023 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37819980
2.
The primary familial brain calcification-associated protein MYORG is an α-galactosidase with restricted substrate specificity.
PLoS Biol
; 20(9): e3001764, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36129849
3.
A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells.
Proc Natl Acad Sci U S A
; 119(29): e2200553119, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35858317
4.
Understanding and exploiting the roles of O-GlcNAc in neurodegenerative diseases.
J Biol Chem
; 299(12): 105411, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37918804
5.
Chemoproteomic identification of CO2-dependent lysine carboxylation in proteins.
Nat Chem Biol
; 18(7): 782-791, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35710617
6.
Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates.
Nat Chem Biol
; 18(3): 332-341, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35210619
7.
Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of α-Iduronidase, ß-Glucuronidase and Heparanase.
Chembiochem
; 24(4): e202200619, 2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36453606
8.
Potent and Selective Cell-Active Iminosugar Inhibitors of Human α-N-Acetylgalactosaminidase (α-NAGAL).
Chemistry
; 29(44): e202300982, 2023 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37217457
9.
The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila.
Proc Natl Acad Sci U S A
; 117(4): 2004-2013, 2020 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932432
10.
Altered Tau Kinase Activity in rTg4510 Mice after a Single Interfaced CHIMERA Traumatic Brain Injury.
Int J Mol Sci
; 24(11)2023 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37298388
11.
Potent De Novo Macrocyclic Peptides That Inhibit O-GlcNAc Transferase through an Allosteric Mechanism.
Angew Chem Int Ed Engl
; 62(5): e202215671, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36460613
12.
A Fixable Fluorescence-Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells.
Angew Chem Int Ed Engl
; 62(40): e202309306, 2023 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37582679
13.
Thermal Proteome Profiling Reveals the O-GlcNAc-Dependent Meltome.
J Am Chem Soc
; 144(9): 3833-3842, 2022 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35230102
14.
Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications.
J Am Chem Soc
; 144(2): 832-844, 2022 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34985906
15.
O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.
Mol Cell
; 54(5): 820-31, 2014 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24857547
16.
sp2-Iminosugars targeting human lysosomal ß-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease.
J Enzyme Inhib Med Chem
; 37(1): 1364-1374, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35575117
17.
Discovery of a New Drug-like Series of OGT Inhibitors by Virtual Screening.
Molecules
; 27(6)2022 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35335358
18.
Pharmacological Chaperones for GCase that Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models.
Angew Chem Int Ed Engl
; 61(38): e202207974, 2022 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35864061
19.
The structure of a family 110 glycoside hydrolase provides insight into the hydrolysis of α-1,3-galactosidic linkages in λ-carrageenan and blood group antigens.
J Biol Chem
; 295(52): 18426-18435, 2020 12 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33127644
20.
Rational design of cell active C2-modified DGJ analogues for the inhibition of human α-galactosidase A (GALA).
Org Biomol Chem
; 19(37): 8057-8062, 2021 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34494637