Detalhe da pesquisa
1.
Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects.
Proc Natl Acad Sci U S A
; 118(25)2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34140407
2.
Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
J Cell Mol Med
; 22(2): 823-833, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28994238
3.
Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites.
Dev Cell
; 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38626765
4.
Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-ß accumulation in a mouse model of amyloid pathology.
Acta Neuropathol Commun
; 11(1): 82, 2023 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37198698
5.
Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites.
Front Neurosci
; 16: 900338, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35801175
6.
Structural Determinant of ß-Amyloid Formation: From Transmembrane Protein Dimerization to ß-Amyloid Aggregates.
Biomedicines
; 10(11)2022 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36359274
7.
An evaluation of the self-assembly enhancing properties of cell-derived hexameric amyloid-ß.
Sci Rep
; 11(1): 11570, 2021 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34078941
8.
Erratum: Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization.
iScience
; 24(2): 102057, 2021 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33554063
9.
Mechanism of Cellular Formation and In Vivo Seeding Effects of Hexameric ß-Amyloid Assemblies.
Mol Neurobiol
; 58(12): 6647-6669, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34608607
10.
Modulating the endoplasmic reticulum stress response attenuates neurodegeneration in a Caenorhabditiselegans model of spinal muscular atrophy.
Dis Model Mech
; 13(12)2020 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33106327
11.
Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes.
Front Neurosci
; 14: 586108, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33551720
12.
Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization.
iScience
; 23(12): 101887, 2020 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33367225
13.
Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release.
eNeuro
; 7(3)2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32327470