REPERFUSION INJURY IN ACUTE PERIOD OF MYOCARDIAL INFARCTION - WAYS OF PREVENTION AND CORRECTION.

OBJECTIVE: The aim: To identify pathophysiological peculiarities of myocardial reperfusion injury and ways of its reduction based on the literature data analysis. PATIENTS AND METHODS: Materials and methots: This literature review was made by searching the PubMed database using key words . Additional data were sought in the Google search engine by entering key words: " risk factors, ischemic heart disease, arrhythmia, sudden cardiac death, heart rhythm, heart failure." in the Polish, English, Russian and Ukrainian language versions. CONCLUSION: Conclusions: Considering conducted data analysis, provided data indicate the prospects of phosphocreatine usage in treatment scheme of heart rhythm disorders and heart failure on the background of myocardial ischemia and elimination of reperfusion injury and myocardial remodeling consequences.

VENTRIСULAR ECTOPIC ACTIVITY - A PREDICTOR OF SUDDEN CARDIAC DEATH IN PATIENTS WITH ATRIAL FIBRILLATION AND POST-INFARCTION LEFT VENTRICULAR ANEURISMS.

The article presents a clinical case of a patient who died suddenly from a rapid transformation of ventricular extrasystole into high-grade ectopy during persistent atrial fibrillation. All electrical events preceding death were recorded by the Holter monitor, which the patient was wearing at the time. It was revealed that post-infarction left ventricular aneurysm can be specified as the main predictor of sudden cardiac death, given that the myocardial scar tissue is an arrhyth¬mogenic substrate of pathological re-entry circuits to initiate high-rate ventricular arrhythmias. Heart rate variability and heart rate turbulence, as well as frequent ventricular ectopy plays significant role in the pathological mechanisms of fatal arrhythmias. Complex cardiac arrhythmias combined with changes in the autonomic regulation of the cardiovascular system are early predictors of sudden cardiac death.