RESUMO
We describe a man with manifestations of the Adams-Oliver syndrome: congenital scalp defect with hypoplastic fingers and toes. The patient has normal first-cousin parents: among seven sibs, three sisters and two brothers are normal; two brothers born with the same scalp lesion died as a consequence of bleeding from this abnormal area. There is no evidence of other affected relatives. The family of our patient is suggestive of autosomal recessive inheritance of this disorder with phenotypic manifestations identical to those present in the autosomal dominant form. Dermatoglyphic findings are discussed.
Assuntos
Anormalidades Múltiplas/genética , Deformidades Congênitas dos Membros , Couro Cabeludo/anormalidades , Crânio/anormalidades , Adulto , Dermatoglifia , Genes Recessivos , Humanos , Masculino , Linhagem , SíndromeRESUMO
We present a dup (10p) due to a t(10;14) (p11;p12)mat with a malformation syndrome in a girl. The analysis of 37 published cases shows that 31 patients (16 males; 15 females) had either a mother or a father carrying a balanced translocation; one case was due to a paternal and another due to a maternal pericentric inversion; two cases were due to de novo translocations; one case had a partial duplication of 10p; and one case had a supernumerary ring chromosome composed of 10p material. The phenotypic spectrum of the condition was analyzed. It is a specific multiple congenital anomalies/mental retardation (MCA/MR) syndrome which includes characteristic facial appearance (dolichocephaly, frontal bossing, short nose with a broad root, highly arched and upswept eyebrows, long philtrum, and thin lips), postnatal growth retardation, severe mental and psychomotor retardation, and several major and minor anomalies. Pseudohermaphroditism seems to be an important anomaly being present in 15 to 20% of affected males. A hypothenar crease together with a transverse crease forming a "crease triangle" seems a helpful sign in the clinical diagnosis of duplication 10p.
Assuntos
Anormalidades Múltiplas/genética , Aberrações Cromossômicas , Cromossomos Humanos 13-15 , Cromossomos Humanos 6-12 e X , Translocação Genética , Dermatoglifia , Face/anormalidades , Feminino , Transtornos do Crescimento/genética , Humanos , Lactente , Deficiência Intelectual , Fenótipo , SíndromeRESUMO
We describe a girl with the manifestations of geleophysic dwarfism: small stature, a peculiar but pleasant and good-natured facial appearance, a dysostosis-multiplex-like bone dysplasia affecting predominantly hands and feet, hepatomegaly and stenosis, and insufficiency of the aortic valve. The proposita's sister died of heart failure at 3 years and was reported by the mother to have been a tiny child with small hands.
Assuntos
Anormalidades Múltiplas/genética , Nanismo/genética , Criança , Dermatoglifia , Feminino , Deformidades Congênitas do Pé , Deformidades Congênitas da Mão , Humanos , SíndromeRESUMO
We report on a family in which a maternal translocation (7;9) (7qter----7p22::9p13----9pter; 9qter----9p13) resulted in 2 sibs with dup(9p) syndrome, one sib with the same balanced constitution as the mother, and one normal boy.
Assuntos
Anormalidades Múltiplas/genética , Cromossomos Humanos 6-12 e X , Deficiência Intelectual/genética , Translocação Genética , Adolescente , Aneuploidia , Dermatoglifia , Feminino , Transtornos do Crescimento/genética , Heterozigoto , Humanos , Hipertelorismo/genética , Lactente , Cariotipagem , Masculino , TrissomiaRESUMO
We describe 2 unrelated patients, a boy and a girl, with an overgrowth syndrome and the following common characteristics: macrocrania, obesity, ocular abnormalities (retinal coloboma and nystagmus), downward slant of palpebral fissures, mental retardation, and delayed bone maturation. Both cases are of sporadic occurrence with no consanguinity between the parents. We suggest that this syndrome is due to a new autosomal dominant mutation and propose to designate it with the acronym of "MOMO syndrome" (Macrosomia, Obesity, Macrocrania, Ocular anomalities.
Assuntos
Anormalidades Múltiplas , Anormalidades do Olho , Gigantismo , Deficiência Intelectual , Obesidade , Criança , Pré-Escolar , Feminino , Genes Dominantes , Cabeça/anormalidades , Humanos , Masculino , SíndromeRESUMO
We describe a boy with mild manifestations of the Bannayan-Zonana syndrome (BZS): large scaphocephalic head with marked frontal bossing, hypertrophy on the right side of the body, large and irregular café-au-lait spots, and cutaneous telangiectasia on large parts of the body and a cavernous hemangioma on the internal side of the left leg; soft cutaneous masses were present in the left axilla and inner part of the left arm; hypotonia and mild neurologic dysfunction were also present. BZS is reported as an autosomal dominant condition with variable expressivity; analysis of our data and those reported in the literature suggest that the interfamilial variability observed might represent different allelic mutations, or genetic heterogeneity.
Assuntos
Genes Dominantes , Cabeça/anormalidades , Hemangioma/genética , Lipoma/genética , Alelos , Humanos , Lactente , Masculino , Fenótipo , SíndromeRESUMO
We report on a girl with apparent hypomelanosis of Ito (ITO); cytogenetic studies disclosed the karyotype 46,X,t(X;10)(p11;q11)mat. We present further evidence that at least one of the genetic forms of ITO is located at Xp11; reviewing the clinical characteristics of patients with incontinentia pigmenti type 1 (IP1) and ITO with X-autosome translocations, we suggest that IP1 and ITO represent allelic forms or a contiguous gene syndrome. Thus, different genetic alterations in this region (Xp11) give rise to ITO or IP1 or borderline phenotypes. We also suggest that all patients with ITO, due to Xp11 mutation, have functional or genetic mosaicisms.
Assuntos
Cromossomos Humanos Par 10 , Transtornos da Pigmentação/genética , Aberrações dos Cromossomos Sexuais/genética , Translocação Genética , Cromossomo X , Anormalidades Múltiplas/genética , Criança , Mapeamento Cromossômico , Feminino , Humanos , Deficiência Intelectual/genética , Cariotipagem , MosaicismoRESUMO
GAPO syndrome was described in 12 patients from 7 families. Constant manifestations include dwarfism, alopecia, pseudoanodontia, and a peculiar, "geriatric" facial appearance. We describe the autopsy findings and all available clinical data on one deceased patient and his living affected sister, previously reported as short abstracts (Epps et al.: Cienc Cult 29(Suppl):740, 1977; Wajntal et al.: Cienc Cult 34(Suppl):705, 1982). Both had the characteristic anomalies of this syndrome but optic atrophy was absent; instead, they had glaucoma and keratoconus; hypogonadism was present in both patients. Biopsy and autopsy findings show that the GAPO syndrome is a dyshistogenetic sequence due to accumulation of extracellular material and thus should be called GAPO dysplasia. We suggest that the basic defect in this autosomal recessive disorder is possibly related to a lack of breakdown of the extracellular components, perhaps due to an enzyme deficiency involved in the metabolism of extracellular matrix.
Assuntos
Anormalidades Múltiplas/genética , Alopecia/genética , Anodontia/genética , Doenças do Tecido Conjuntivo/genética , Nanismo/genética , Atrofia Óptica/genética , Adulto , Criança , Face/anormalidades , Feminino , Seguimentos , Genes Recessivos , Humanos , Masculino , Linhagem , SíndromeRESUMO
Deletion 11q23-->qter and duplication 12q23-->qter are described in a boy with neuroblastoma, multiple congenital anomalies, and mental retardation. The patient has clinical manifestations of 11q deletion and 12q duplication syndromes. The possible involvement of the segment 11q23-->24 in the cause of the neuroblastoma is discussed.
Assuntos
Anormalidades Múltiplas/genética , Aberrações Cromossômicas , Transtornos Cromossômicos , Cromossomos Humanos Par 11 , Cromossomos Humanos Par 12 , Deficiência Intelectual/genética , Neuroblastoma/genética , Adulto , Bandeamento Cromossômico , Deleção Cromossômica , Mapeamento Cromossômico , Feminino , Humanos , Lactente , Deficiência Intelectual/complicações , Cariotipagem , Linfócitos/patologia , Masculino , Neuroblastoma/complicaçõesRESUMO
Syndromes with associated overgrowth are poorly understood. Besides their mode of inheritance, nothing is known regarding the basic genetic alterations that lead to their abnormal phenotypic manifestations. The chromosome localization of the genes involved remains unknown for this group of syndromes, with the only exception being the Wiedemann-Beckwith syndrome.
Assuntos
Anormalidades Múltiplas/genética , Cromossomos Humanos Par 12 , Cromossomos Humanos Par 15 , Transtornos do Crescimento/genética , Pré-Escolar , Aberrações Cromossômicas , Feminino , Humanos , Lactente , Cariotipagem , MasculinoRESUMO
The authors present a case of an 11-month-old girl with the medial cleft face syndrome and the following malformations: ocular hyperterolism, primary telecanthus, cleft nose with absent tip, broad nasal root, complete absence of the left upper lid, and abnormal hair-line implantation in the corresponding frontal region, high arched palate, neurosensorial deafness and agenesia of the right kidney. The authors propose that the eyelid is responsible for the area of hair growth suppression around the eyes. This is the first case report of median cleft face syndrome associated with renal agenesia.
Assuntos
Disostose Craniofacial/complicações , Pálpebras/anormalidades , Face/anormalidades , Hipertelorismo/complicações , Rim/anormalidades , Úlcera da Córnea/complicações , Feminino , Perda Auditiva Bilateral/complicações , Humanos , Lactente , Masculino , Nariz/anormalidades , Gravidez , Couro Cabeludo/anormalidades , Síndrome , Ureter/anormalidadesRESUMO
Children with Sotos syndrome have growth acceleration, macrocephaly, acromegaloid features and delay in neuropsychomotor development during infancy. Syndrome delineation and differential diagnosis are based on evaluation of phenotypic characteristics and evolutive history of the patients. Seven patients with this syndrome are reported, and the relative occurrence of the phenotypic characteristics present in 198 reported cases are reviewed. Motor difficulties present in those patients during early infancy are responsible for the poor performance on IQ tests. Oriented stimulation should be encouraged in order to help the affected children to overcome their initial difficulties and to achieve normal scholarity and life performance.
Assuntos
Encefalopatias/complicações , Gigantismo/complicações , Transtornos Psicomotores/etiologia , Adulto , Estatura , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Fenótipo , Transtornos Psicomotores/fisiopatologia , Desempenho Psicomotor , SíndromeRESUMO
We described a D1 trisomy syndrome patient who had a normal 46,XX cell line and 15.4% of lymphocytes with a 47,XX, + D chromosome constitution as an occasion to review normal trisomy 13 mosaicism.
Assuntos
Anormalidades Múltiplas/genética , Cromossomos Humanos 13-15 , Mosaicismo , Trissomia , Feminino , Humanos , Lactente , Deficiência Intelectual/genética , Linfócitos/ultraestrutura , Microcefalia/genética , SíndromeRESUMO
Brazilian Cracidae are threatened by heavy environmental degradation and hunting. The Black-fronted piping-guan (Pipile jacutinga) used to inhabit the Atlantic coastal highland forests. Now it occurs in limited forest areas where it is rarely seen. Interative management, including captive breeding, might be an important action for its survival. We present data on DNA fingerprinting using Jeffreys' human minisatellite probes 33.6 and 33.15. Our results show that this technique is useful for estimating the genetic variability of natural populations and may help to maintain the genetic variability of captive bred individuals of this species. A linkage analysis of the fingerprint profiles in a family with 7 chicks was performed (to estimate the number of independently segregating loci detected in this species) and at least 16 highly polymorphic independent loci were identified for each probe.
Assuntos
Aves/genética , Cruzamento/estatística & dados numéricos , Impressões Digitais de DNA/tendências , Animais , Impressões Digitais de DNA/métodos , Ecologia , Variação Genética/genética , Repetições Minissatélites/genéticaRESUMO
A 39 year old male with multiple dysmorphic features was found to have an unstable ring chromosome 7. Clinical findings are presented and compared with the other five reported cases of ring chromosome 7. The main characteristics found in patients with this chromosome constitution are prenatal onset growth deficiency, bone anomalies, pigmentary or vascular skin changes, and ocular and genital anomalies.
Assuntos
Anormalidades Múltiplas/diagnóstico , Aberrações Cromossômicas , Cromossomos Humanos Par 7 , Cromossomos em Anel , Anormalidades Múltiplas/genética , Adulto , Bandeamento Cromossômico , Humanos , Deficiência Intelectual , MasculinoRESUMO
The H-Y antigen is a plasma membrane antigen involved in the organogenesis of the mammalian testis. Its expression on human cells is determined by a Y-linked gene. Phenotypic females affected by 46,XY gonadal dysgenesis (Swyer's syndrome) can be either H-Y-positive or H-Y-negative. In this paper we report H-Y antigen and endocrine studies in a sibship with three affected sisters. Immunological studies were performed on two of the patients, and a clearly positive expression was detected in both cases. Endocrine studies consisted in the investigation of the hypothalamic-pituitary-gonadal axis, which revealed that gonadal hormone insufficiency is the only endocrine abnormality associated with the syndrome. A new genetic interpretation and calssification of XY gonadal dysgenesis is proposed.