Detalhe da pesquisa
1.
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease.
J Neuroinflammation
; 20(1): 286, 2023 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38037070
2.
APOE and immunity: Research highlights.
Alzheimers Dement
; 19(6): 2677-2696, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36975090
3.
LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function.
Hum Mol Genet
; 28(16): 2696-2710, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31039583
4.
LRRK2 regulation of immune-pathways and inflammatory disease.
Biochem Soc Trans
; 47(6): 1581-1595, 2019 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31769472
5.
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Hum Mol Genet
; 25(5): 951-63, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26744332
6.
Investigating the Role and Regulation of GPNMB in Progranulin-deficient Macrophages.
bioRxiv
; 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38558966
7.
Disease mechanisms as subtypes: Lysosomal dysfunction in the endolysosomal Parkinson's disease subtype.
Handb Clin Neurol
; 193: 33-51, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36803821
8.
ASO-mediated knockdown or kinase inhibition of G2019S-Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages.
Mol Ther Nucleic Acids
; 34: 102064, 2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38028198
9.
Totally tubular: ASO-mediated knock-down of G2019S -Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages.
bioRxiv
; 2023 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37503274
10.
The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner.
bioRxiv
; 2023 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37905053
11.
Inflammation and immune dysfunction in Parkinson disease.
Nat Rev Immunol
; 22(11): 657-673, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35246670
12.
WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson's Disease Monocytes.
Front Cell Neurosci
; 16: 892899, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35755775
13.
Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system.
Front Immunol
; 13: 1056417, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36618392
14.
Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism.
Sci Transl Med
; 13(594)2021 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34011628
15.
LRRK2 at the Interface Between Peripheral and Central Immune Function in Parkinson's.
Front Neurosci
; 14: 443, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32508566
16.
Linking mitochondria to the immune response.
Elife
; 92020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32293561
17.
Lysosomal Dysfunction at the Centre of Parkinson's Disease and Frontotemporal Dementia/Amyotrophic Lateral Sclerosis.
Trends Neurosci
; 42(12): 899-912, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31704179
18.
Cellular processes associated with LRRK2 function and dysfunction.
FEBS J
; 282(15): 2806-26, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25899482