On-Chip Meta-Optics for Engineering Arbitrary Trajectories with Longitudinal Polarization Variation.

On-chip integrated meta-optics promise to achieve high-performance and compact integrated photonic devices. To arbitrarily engineer the optical trajectory along the propagation path in an on-chip integrated scheme is of significance in fundamental physics and various emerging applications. Here, we experimentally demonstrate an on-chip metasurface integrated on a waveguide to enable predefined arbitrary optical trajectories in the visible regime. By transformation of the transverse phase to generate longitudinal mapping, the guided waves are extracted and molded into any different optical trajectories (parabola, hyperbola, and cosine). More intriguingly, predefined polarization states with longitudinal variation are also successfully imparted along the trajectory. Owing to the on-chip propagation scheme, the trajectories are uniquely free from zero-order diffraction interference, naturally having a higher signal-to-noise ratio beyond conventional free-space forms. Overall, such on-chip optical trajectory engineering allows for miniaturized integration and can find paths in potential applications of complex optical manipulation, advanced laser fabrication, and microscopic imaging.

Octave soliton microcombs in lithium niobate microresonators.

Soliton microcombs are regarded as an ideal platform for applications such as optical communications, optical sensing, low-noise microwave sources, optical atomic clocks, and frequency synthesizers. Many of these applications require a broad comb spectrum that covers an octave, essential for implementing the f - 2f self-referencing techniques. In this work, we have successfully generated an octave-spanning soliton microcomb based on a z-cut thin-film lithium niobate (TFLN) microresonator. This achievement is realized under on-chip optical pumping at 340 mW and through extensive research into the broadening of dual dispersive waves (DWs). Furthermore, the repetition rate of the octave soliton microcomb is accurately measured using an electro-optic comb generated by an x-cut TFLN racetrack microresonator. Our results represent a crucial step toward the realization of practical, integrated, and fully stabilized soliton microcomb systems based on TFLN.

Repetition rate tuning and locking of solitons in a microrod resonator.

Recently, there has been significant interest in the generation of coherent temporal solitons in optical microresonators. In this Letter, we present a demonstration of dissipative Kerr soliton generation in a microrod resonator using an auxiliary-laser-assisted thermal response control method. In addition, we are able to control the repetition rate of the soliton over a range of 200 kHz while maintaining the pump laser frequency, by applying external stress tuning. Through the precise control of the PZT voltage, we achieve a stability level of 3.9 × 10-10 for residual fluctuation of the repetition rate when averaged 1 s. Our platform offers precise tuning and locking capabilities for the repetition frequency of coherent mode-locked combs in microresonators. This advancement holds great potential for applications in spectroscopy and precision measurements.

Thermal oscillation in the hybrid Si3N4 - TiO2 microring.

The hybrid microcavity composed of different materials shows unique thermal-optical properties such as resonance frequency shift and small thermal noise fluctuations with the temperature variation. Here, we have fabricated the hybrid Si3N4 - TiO2 microring, which decreases the effective thermo-optical coefficients (TOC) from 23.2pm/K to 11.05pm/K due to the opposite TOC of these two materials. In this hybrid microring, we experimentally study the thermal dynamic with different input powers and scanning speeds. The distorted transmission and thermal oscillation are observed, which results from the non-uniform scanning speed and the different thermal relaxation times of the Si3N4 and the TiO2. We calibrate the distorted transmission spectrum for the resonance measurement at the reverse scanning direction and explain the thermal oscillation with a thermal-optical coupled model. Finally, we analyse the thermal oscillation condition and give the diagram about the oscillation region, which has significant guidance for the occurrence and avoidance of the thermal oscillation in practical applications.

Thermal tuning of mode crossing and the perfect soliton crystal in a Si3N4 microresonator.

Dissipative Kerr solitons in high quality microresonators have attracted much attention in the past few years. They provide ideal platforms for a number of applications. Here, we fabricate the Si3N4 microring resonator with anomalous dispersion for the generation of single soliton and soliton crystal. Based on the strong thermal effect in the high-Q microresonator, the location and strength of the avoided mode crossing in the device can be changed by the intracavity power. Because the existence of the avoided mode crossing can induce the perfect soliton crystal with specific soliton number, we could choose the appropriate pumped resonance mode and appropriate pump power to obtain the perfect soliton crystals on demand.

All-Optical Synchronization of Remote Optomechanical Systems.

Synchronization and frequency locking between remote mechanical oscillators are of scientific and technological importance. The key challenges are to align the oscillation frequencies and realize strong nonlinear interaction of both oscillators to a common carrier capable of long-distance transmission. Here, we experimentally realize the all-optical synchronization between two different optomechanical systems, a microsphere and a microdisk. The mechanical oscillation of the microsphere induced by the radiation pressure is loaded onto the pump laser via the optomechanical interaction, which is directly transmitted through a 5-km-long single-mode fiber to excite the mechanical oscillation of the microdisk. By finely tuning both the optical and mechanical frequencies of the two microresonators, the oscillation of the microdisk is injection locked to the microsphere, resulting in a synchronized phase relation of the two systems. Our results push a step forward the long-distance synchronization network using optomechanical microresonators.

Numerical characterization of soliton microcomb in an athermal hybrid Si3N4-TiO2 microring.

We theoretically investigate the athermal constructions to cancel the thermorefractive effect of a hybrid Si3N4-TiO2 microring, which merges two materials with opposite thermo-optical coefficients (TOCs). The analytical and numerical results predict that the thermorefractive effect can be reduced under the appropriate parameters. In addition, the soliton state is easily accessed under the athermal condition. The thermorefractive noise due to the fluctuation of the microresonator temperature caused by the heat exchange between the microresonator and the surrounding environment is also suppressed by one order of magnitude, which is critical for the potential applications of soliton microcombs, such as spectroscopy, optical clocks and microwave generation.

3D Meta-Prisms for Versatile Beam Steering by Hybridizing Plasmonic and Diffractive Effect in the Broadband Visible Regime.

As two independent optical sub-fields, diffraction optics and plasmonics both have been used for wavefront shaping and beam steering. However, the two separate concepts have always been developing as two parallel directions, which have not met for studying their structural hybridization to discover new potentials. For instance of the flat metasurfaces, even though the geometric parameters including shape, size, and periodicity have been studied, it remains mostly unexplored for the 3D spatial height variation. Here, a new type of all-metallic 3D meta-prism is proposed and experimentally demonstrated by hybridizing the localized surface plasmonic resonances (LSPR) and the blazed grating diffraction, which enables strong polarization-dependent behaviors to steer broadband visible light to drastically inverse directions. The nanofabrication of 3D meta-prism is achieved by nanostencil lithography with electron-beam evaporation. Such meta-prism could also enable to split different visible light (green, blue, and red) with high-efficiency contrast (≈10). By the mirror-symmetry arrangement, a multifunctional surface is demonstrated with polarization-/wavelength-multiplexing wavefront-shaping functions (concave, convex, or flat mirror). This unique 3D meta-prism enjoys great simplicity and versatility in broadband beam steering through the incorporation of plasmonic and diffractive effects and can be utilized in various applications including dichroic-prism splitters, multifunctional meta-mirrors, etc.

Dual-encryption freedom via a monolayer-nanotextured Janus metasurface in the broadband visible.

As an emerging category of two-faced 2D architecture, the Janus metasurface aims to explore another universal optical property, that is, the wavevector direction (k-direction), and to enable the asymmetric transmission between the opposite directional incidences. It exhibits significant potential in creating versatile multiplexing metasurfaces and an optical isolator in optical communication applications. However, most previous asymmetric functionality shows merely one-way functionality with the other-way simply muted or demands multilayered nanostructure fabrication and alignment. Hence, it remains a great challenge to make a monolayer-nanotextured Janus metasurface with dual-encryption freedom and conquering the difficulty for multilayer alignment and practical operation bandwidth. In this work, we have proposed and experimentally demonstrated a new strategy of a dual-encryption Janus metasurface design with a simple monolayer-nanotextured metasurface coupled with a commercialized film of the half-wave plate. Utilizing the hybridization from two independent geometrical dimensions of rectangular-antennas, our approach ingeniously transforms the polarization-multiplexing into the dual-directional channels. A series of calculations and experimental results demonstrate that our asymmetric approach simultaneously constructs completely independent imaging encryptions for both forward and backward directions. Additionally, our proposed approach becomes a practical scheme with broadband visible-frequency operation and great simplicity in design and nanofabrication. We believe the universal scheme could facilitate to increase the information encoding capacity and holographic multiplexing channels by expanding the illumination wavevector to the full-space (+/-), and it paves the route toward the potential applications in on-chip integration, telecommunications, encryption, information processing, and communication.

Polarization-insensitive broadband visible-light steering with tunable direction enabled by scalable plasmonics meta-gratings.

As an emerging field in the discipline of optics, plasmonics and metasurfaces have been demonstrated to enable a new degree of freedom to manipulate light for arbitrary beam steering, spectral splitting as well as precise wavefront shaping. However, it has been mostly studied in parallel with the field of diffractive optics, and awaits the unveiling of how the hybridizations between plasmonic effect and diffraction effect interact and impact. Here, we have theoretically proposed a new type of polarization-insensitive meta-grating structure across the broadband visible regime. The structure design combines the width gradient (critical resonant length) from a trapezoid-nanoantenna with the height gradient from a blazed grating profile. The hybridized meta-grating creates both plasmonic effect and grating effect, which enables all the optical incident photons to be directed to the same orientation regardless of the light polarization. As we know, both metasurfaces and diffractive optical elements (such as gratings) are, more often than not, quite sensitive to the incident light polarization. Moreover, if placing our meta-grating on a flexible/stretchable substrate (such as polydimethylsiloxane), the outgoing angle can be effectively adjusted by tuning the period or density of meta-grating arrays. Such meta-grating architectures can be potentially manufactured by existing photolithography and nanoimprint techniques, and can easily find a wide range of practical polarization-insensitive applications, including broadband deflector and emitter, tunable display and imaging device, high signal-to-noise ratio spectrometer, polarization-insensitive plasmonic coupler, etc.

High-NA achromatic diffractive lensing for arbitrary dual-wavelengths enabled by hybridized metal-insulator-metal cavities.

A new type of diffractive lens based on hybridized Fabry-Perot (FP) cavities with high-NA and achromatic features for arbitrary dual-wavelengths is theoretically proposed and demonstrated. We utilize the subwavelength-scale metal-insulator-metal nanocavity to form a Fresnel zone plate (MIM-FZP) that benefits from both spectral selectivity and high numerical aperture (NA > 0.9) to enable lensing functionality. By taking advantage of the different transmission orders from MIM, any arbitrary dual-wavelength achromatic focusing design is achieved. Using this approach, we merge two independent MIM-FZP designs and realize achromatic focusing performance at the selected dual-wavelength of 400/600 nm. Furthermore, the achromatic lens also exhibits a crucial potential for dynamically tuning of the operation wavelengths and focusing lengths as actively scaling the core layer thickness of MIM. The unique MIM-FZP design can be practically fabricated using a grayscale lithography technique. We believe such high-NA and achromatic optical devices enjoy great simplicity for structural design and can easily find applications including high-resolution imaging, new-generation integrated optoelectronic devices, confocal collimation, and achromatic lens, etc.

Perpendicular coupler for standing wave excitation and wavelength selection in high-Q silicon microresonators.

High quality factor (Q) whispering gallery mode (WGM) resonators have been widely applied in photonics, while the excitation and collection of WGMs are mostly restricted to traveling wave coupler. Here, we experimentally demonstrate a novel on-chip perpendicular coupler (PC) for high-Q (∼1.1 × 105) silicon whispering gallery microresonators. The PC is compact and allows efficiently tunneling coupling between the waveguide and the microresonator, hence it holds great potential for fan-out photonic devices. Drastically different from the traveling wave couplers, standing wave mode can be excited through the PC. In addition, a PC working as an output coupler can also selectively collect the resonance of different wavelengths by locating on different azimuth angles. Our results show the feasibility of such novel coupler for WGM resonators and its potential use in future applications of integrated high Q microresonators.

On-chip metalenses based on one-dimensional gradient trench in the broadband visible.

Metasurfaces are composed of flat, ultrathin subwavelength nanoantennas with strong capability in manipulating light propagation by modulations on its phase, amplitude, and polarization. For instance, the invention of two-dimensional (2D) metalenses has enabled light focusing and imaging in three-dimensional (3D) free space with miniaturized thickness and device size at a planar surface. However, such inherent form of 2D arrays and focusing functionality at 3D optical free-space limits the degree of freedom for light propagation and manipulation along a 2D planar surface and eventually the possibility of on-chip photonic system integration. Here, we theoretically study and demonstrate a new type of planar on-chip metalens, which enables light focusing and strong localization at a 2D surface. The planar on-chip architecture design is based on the one-dimensional (1D) length or width gradient trench metalens (GTM), which could yield the elaborately engineered phase shift for propagating light within the on-chip waveguide at the visible wavelength of 500 nm. By generating 1D phase arrangement at the nanoscale, a miniature on-chip metalens with ∼3×0.5µm dimension could achieve light focusing on a 2D waveguide surface with the flexibility to design scalable focal lengths and ultra-high numerical aperture of up to ∼0.99. Additionally, GTM metalens designs could also exhibit overlapped high depth-of-focus, which consequently could behave as achromatic-like lensing at the selected focal plane. Furthermore, we manifest that the focusing functionality can also be subject to dynamically tuning and switching on-and-off with TE/TM polarization change or waveguide index alteration. We believe this new form of on-chip 1D metalens holds potential applications including on-chip light manipulation functionality of focusing and diverging, optical on-chip sensing, next-generation on-chip optical communication, signal processing as well as imaging devices, etc.

Gene identification and functional analysis of peptidoglycan recognition protein from the spotted sea bass (Lateolabrax maculatus).

Peptidoglycan recognition proteins (PGRPs), which are structurally conserved innate immune molecules in invertebrate and vertebrate animals, play the important roles in regulation of innate immune responses. In this paper, three PGRP genes of spotted sea bass, Lateolabrax maculatus, were cloned, designated as Ssb-PGRP2, Ssb-PGRP-L2 and Ssb-PGRP-SC2, respectively. Sequence analysis showed that the deduced amino acid sequences of Ssb-PGRP2, Ssb-PGRP-L2 and Ssb-PGRP-SC2 proteins contained respectively 468, 482 and 167 amino acid residues, and had the typical structural features of PGRPs, i.e. conserved PGRP domain and Zn2+ binding domain including four specific amino acid residues which were required for amidase activity. q-PCR analysis of total mRNA showed that the mRNA expression of three PGRP genes were detected in all the examined tissues and the expression patterns of Ssb-PGRP2, Ssb-PGRP-L2 and Ssb-PGRP-SC2 were different. After injected with LPS, Poly (I:C) and Edwardsiella tarda, there was a clear time-dependent expression pattern for each of the three PGRP genes in head kidney, spleen, intestine and gill of the spotted sea bass. In our study, three recombinant proteins corresponding to the three members of the peptidoglycan recognition protein family were expressed and purified. Moreover, all of the three recombinant PGRP proteins significantly inhibited bacterial survival and growth, and expressed bactericidal effects on Vibrio harveyi, Staphylococcus aureus and Edwardsiella tarda. In particular, it was firstly verified that their antimicrobial activity presented the superimposed effect. Overall, these findings indicated that three PGRP genes of spotted sea bass were at least involved in host defense against bacterial infections.

Correlation between the level of microRNA expression in peripheral blood mononuclear cells and symptomatology in patients with generalized anxiety disorder.

This study investigated the correlation between the level of microRNA expression in peripheral blood mononuclear cells (PBMCs) and symptomatology in patients with generalized anxiety disorder (GAD). MicroRNA array was performed in peripheral blood mononuclear cells (PBMCs) obtained from GAD patients with gender, age, ethnicity-matched healthy controls. Then real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to verify the top 7 miRNAs with the highest fold-change values in 76 GAD patients and 39 healthy controls. It demonstrated that 5 miRNAs showed significantly differences in expression levels (P<0.01). These 5 GAD-associated miRNAs were finally selected into our study to analyze the association between the plasma level of miRNAs expression and symptomatology scores in Hamilton Anxiety Scale (HAMA). Results showed that the level of miR-4505 and miR-663 was negatively correlated with the total HAMA scores in GAD patients (r=0.2228, r=0.264 P<0.05). MiR-663 was selected into the regression equation of HAMA total scores and psychic anxiety symptomatology scores, and it could explain 5.3% of the HAMA total scores and 15.3% of the anxiety symptomatology scores. This study analyzed preliminarily possible circulating miRNAs expression changes in GAD patients, and the expression level of miR-663 highly correlated with psychic anxiety symptoms, further molecular mechanism of which needs to be explored.

High-Q lithium niobate microdisk resonators on a chip for efficient electro-optic modulation.

Lithium niobate (LN) microdisk resonators on a LN-silica-LN chip were fabricated using only conventional semiconductor fabrication processes. The quality factor of the LN resonator with a 39.6-µm radius and a 0.5-µm thickness is up to 1.19 × 10(6), which doubles the record of the quality factor 4.84 × 10(5) of LN resonators produced by microfabrication methods allowing batch production. Electro-optic modulation with an effective resonance-frequency tuning rate of 3.0 GHz/V was demonstrated in the fabricated LN microdisk resonator.

[Relationship between clinical features and cognitive function in patients with childhood and adolescence-onset schizophrenia].

OBJECTIVE: To explore the factors influencing cognitive functions in patients with childhood and adolescence-onset schizophrenia. METHODS: The clinical data of 78 patients with childhood and adolescence-onset schizophrenia who met with the criteria of ICD-10 for schizophrenia were retrospectively reviewed. The cognitive functions were evaluated by the Chinese Wechsler Intelligence Scale for Children (C-WISC), the Wisconsin Card Sorting Test (WCST), digit span backward and P300. The clinical symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS). RESULTS: The patients with a lower education level or earlier onset of age had a longer P3 latency at the P300Fz area. The patients with a higher parental education level had higher scores of full intelligence quotient (FIQ), verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ), conceptual level and completed categories of WCST and backward numeric order reciting. The patients with higher PANSS negative subscale scores had lower scores of FIQ, VIQ, PIQ, completed categories and conceptual level of WCST and backward numeric order reciting. The patients with a longer stabilization time had higher backward numeric order reciting scores. CONCLUSIONS: The severity of negative symptoms of the patients and the educational level of their parents are major factors influencing cognitive functions in patients with childhood and adolescence-onset schizophrenia.

[Effect of parent training in combination with methylphenidate treatment on family relationships for children with attention deficit/hyperactivity disorder].

OBJECTIVE: To investigate the effect of parent training combined with methylphenidate treatment on family relationships in children with attention deficit/hyperactivity disorder (ADHD). METHODS: Fifty-nine parents of children with ADHD under methylphenidate treatment participated in a modified 5-week training program. The intervention effect was evaluated using the Conners Parent Symptom Questionnaire, ADHD Rating Scale-IV Home Version (ADHD-RS-IV Home Version), Caregiver Strain Questionnaire, Parent-Child Relationship Self-rating Scale and Piers-Harris Children's Self-Concept Scale. Parents also completed the training satisfaction survey before and after the intervention. RESULTS: After the 5-week parent training, compared with the baseline values, total scores of Conners Parent Symptom Questionnaire and scores of conduct problems and anxiety significantly decreased, and scores of attention deficit, hyperactivity, impulsivity and oppositional defiant behaviors of ADHD-RS-IV Home Version, and Caregiver Strain Questionnaire total scores were all significantly decreased (P<0.05), while total scores of the Parent-Child Relationship Self-Rating Scale and Piers-Harris Children's Self-Concept Scale were significantly increased (P<0.05). CONCLUSIONS: Modified 5-week parent training program may improve parent-child relationship and reduce parenting stress in ADHD families.

Multi-Dimensional Light-Emitting Meta-Display: Photoluminescence and Pumping Light Multiplexing.

The advent of intelligent display devices has given rise to diverse and complex demands for miniature light-emitting devices. Light-emitting metasurfaces have emerged as a practical and efficient means of achieving precise light modulation. However, their practicality is limited by certain constraints. First, there is a need for further exploration of the ability to manipulate both pumping and emitting light simultaneously. Second, there is currently no encoding freedom in multi-dimensional emitting light. To address these concerns, using meta-atoms is proposed to encode both fluorescence and pumping light independently, and expand the encoding freedom with different incident wavevector directions. A light-emitting metasurface with quad-fold multiplex encoding meta-displays, including dual scattering images and dual fluorescence images, is further demonstrated. This design strategy not only manipulates both pumping and fluorescence light but also broadens encoding freedom for comprehensive multi-functionality. This can pave the way for multiplexing optical displays, information storage, and next-generation wearable displays.

Switchable unidirectional emissions from hydrogel gratings with integrated carbon quantum dots.

Directional emission of photoluminescence despite its incoherence is an attractive technique for light-emitting fields and nanophotonics. Optical metasurfaces provide a promising route for wavefront engineering at the subwavelength scale, enabling the feasibility of unidirectional emission. However, current directional emission strategies are mostly based on static metasurfaces, and it remains a challenge to achieve unidirectional emissions tuning with high performance. Here, we demonstrate quantum dots-hydrogel integrated gratings for actively switchable unidirectional emission with simultaneously a narrow divergence angle less than 1.5° and a large diffraction angle greater than 45°. We further demonstrate that the grating efficiency alteration leads to a more than 7-fold tuning of emission intensity at diffraction order due to the variation of hydrogel morphology subject to change in ambient humidity. Our proposed switchable emission strategy can promote technologies of active light-emitting devices for radiation control and optical imaging.