Integrated measurement server for measurement-device-independent quantum key distribution network.

Quantum key distribution (QKD), harnessing quantum physics and optoelectronics, may promise unconditionally secure information exchange in theory. Recently, theoretical and experimental advances in measurement-device-independent (MDI)-QKD have successfully closed the physical back door in detection terminals. However, the issues of scalability, stability, cost and loss prevent QKD systems from widespread application in practice. Here, we propose and experimentally demonstrate a solution to build a star-topology quantum access network with an integrated server. By using femtosecond laser direct writing techniques, we construct integrated circuits for all the elements of Bell state analyzer together and are able to integrate 10 such analyzer structures on a single photonic chip. The measured high-visibility Bell state analysis suggests the integrated server as a promising platform for the practical application of MDI-QKD network.

On-chip rotated polarization directional coupler fabricated by femtosecond laser direct writing.

We present a rotated polarization directional coupler (RPDC) on a photonic chip. We demonstrate a double-track approach to modify the distribution of the refractive index between adjacent tracks and form a single waveguide with an arbitrary birefringent optical axis. We construct a RPDC with the two axis-rotated waveguides coupled in a strong regime. The obtained extinction ratios on average are about 16 dB and 20 dB for the corresponding orthogonal polarizations. We perform reconstruction of the Stokes vector to test the projection performance of our RPDC, and observe the average fidelities up to 98.1% and 96.0% for the perfectly initialized states in 0° and 45° RPDCs, respectively.

Comparing Clinical Efficacy of Different Bacillus Calmette-Guérin Strains in Patients With T1 High Grade Bladder Cancer.

BACKGROUND/AIM: This study aimed to compare the clinical efficacy of two different Bacillus Calmette-Guérin (BCG) strains, TICE strain (OncoTICE) and Connaught strain (ImmuCyst), as a first line intravesical instillation therapy in patients with T1 high grade bladder cancer. PATIENTS AND METHODS: Patients with newly diagnosed T1 high-grade bladder cancer who underwent transurethral resection of bladder tumor (TURBT) followed by intravesical instillation therapy were enrolled. The effects of BCG strain on recurrence, progression, and side effects were analyzed using Kaplan-Meier and Cox proportional hazards models. RESULTS: Among 147 patients, 53 patients received Connaught strain and 94 patients received TICE strain. The completion rate of induction instillation was 92.45% in the Connaught group and 91.49% in the TICE group (p=1.00). The three-year recurrence-free survival rate was 71.7% in the Connaught group and 63.83% in the TICE group (p=0.33), whereas the three-year progression-free survival rate was 96.23% in the Connaught group and 89.36% in the TICE group (p=0.21). On Cox regression test, carcinoma in situ and ≥eight lesions were significant predictors for recurrence. No significant difference was observed in recurrence and progression between the two BCG regimens. The complication rates according to the Cleveland Clinic grading system showed no significant difference between the two groups (p=0.13). CONCLUSION: Both the Connaught and TICE strains of BCG demonstrated comparable three-year recurrence-free survival rates and three-year progression-free survival rates for T1 high grade bladder cancer, as well as comparable adverse events. Due to the global BCG shortage, further strain comparisons are essential for clinical validation.