Detalhe da pesquisa
1.
A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors.
Proc Natl Acad Sci U S A
; 119(18): e2120512119, 2022 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35471904
2.
Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.
Proc Natl Acad Sci U S A
; 116(31): 15463-15468, 2019 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31311868
3.
Disruption of IRE1α through its kinase domain attenuates multiple myeloma.
Proc Natl Acad Sci U S A
; 116(33): 16420-16429, 2019 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31371506
4.
RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature
; 526(7574): 583-6, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26466569
5.
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nat Chem Biol
; 14(6): 582-590, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29632413
6.
Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nat Chem Biol
; 14(9): 902, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-29728602
7.
Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.
Proc Natl Acad Sci U S A
; 114(16): 4147-4152, 2017 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28377511
8.
Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies.
Bioconjug Chem
; 30(1): 148-160, 2019 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30566343
9.
An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.
Genes Dev
; 25(22): 2347-60, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22085962
10.
Recurrent R-spondin fusions in colon cancer.
Nature
; 488(7413): 660-4, 2012 Aug 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22895193
11.
Targeting protein-protein interaction by small molecules.
Annu Rev Pharmacol Toxicol
; 54: 435-56, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24160698
12.
Regulation of the oncoprotein Smoothened by small molecules.
Nat Chem Biol
; 11(4): 246-55, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25785427
13.
Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors.
Bioorg Med Chem Lett
; 26(15): 3518-24, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27346791
14.
Association between the incidence of varicella and meteorological conditions in Jinan, Eastern China, 2012-2014.
BMC Infect Dis
; 16: 179, 2016 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27102884
15.
Diverse somatic mutation patterns and pathway alterations in human cancers.
Nature
; 466(7308): 869-73, 2010 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20668451
16.
Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors.
Bioorg Med Chem Lett
; 25(21): 4728-4732, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26338362
17.
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg Med Chem Lett
; 25(3): 529-41, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25556090
18.
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Proc Natl Acad Sci U S A
; 109(14): 5299-304, 2012 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22431598
19.
[Short term effect of weather patterns on the incidence of hand foot and mouth disease aged ≤5 years old in Jinan city].
Zhonghua Yu Fang Yi Xue Za Zhi
; 49(12): 1052-5, 2015 Dec.
Artigo
em Zh
| MEDLINE | ID: mdl-26887298
20.
Characterization of oxidative carbonylation on recombinant monoclonal antibodies.
Anal Chem
; 86(10): 4799-806, 2014 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24731230