Detalhe da pesquisa
1.
A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade.
Mol Cell
; 80(2): 296-310.e6, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32979304
2.
Phosphine-Catalyzed (4 + 2) Annulation of Allenoates Bearing Acidic Hydrogen with 1,1-Dicyanoalkenes.
J Org Chem
; 89(10): 7169-7174, 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38679873
3.
Design, synthesis, and biological evaluation of piperazine derivatives involved in the 5-HT1AR/BDNF/PKA pathway.
J Enzyme Inhib Med Chem
; 39(1): 2286183, 2024 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38078358
4.
Design, synthesis, and biological evaluation of deuterated indolepropionic acid derivatives as novel long-acting pan PPARα/γ/δ agonists.
Bioorg Med Chem
; 96: 117533, 2023 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37976807
5.
Diphenyl Ether Derivatives as Novel GPR120 Agonists for the Treatment of Type 2 Diabetes Mellitus.
Chem Biodivers
; 20(1): e202200814, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36471492
6.
Discovery of a 4-Hydroxy-3'-Trifluoromethoxy-Substituted Resveratrol Derivative as an Anti-Aging Agent.
Molecules
; 29(1)2023 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38202669
7.
Design, synthesis and biological evaluation studies of novel anti-fibrosis agents bearing sulfoxide moiety.
Bioorg Med Chem
; 75: 117096, 2022 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36395681
8.
Bronchoscopic intratumoral injections of cisplatin and endostar as concomitants of standard chemotherapy to treat malignant central airway obstruction.
Postgrad Med J
; 98(1156): 104-112, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33070116
9.
Discovery of Novel and Selective G-Protein Coupled Receptor 120 (GPR120) Agonists for the Treatment of Type 2 Diabetes Mellitus.
Molecules
; 27(24)2022 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36558150
10.
SARS-CoV-2 has the advantage of competing the iMet-tRNAs with human hosts to allow efficient translation.
Mol Genet Genomics
; 296(1): 113-118, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33040198
11.
Design, Synthesis, and In Vivo and In Silico Evaluation of Coumarin Derivatives with Potential Antidepressant Effects.
Molecules
; 26(18)2021 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34577028
12.
Novel GPR120 Agonists with Improved Pharmacokinetic Profiles for the Treatment of Type 2 Diabetes.
Molecules
; 26(22)2021 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34833999
13.
Synthesis of 3,4-dihydroquinolin-2(1H)-one derivatives with anticonvulsant activity and their binding to the GABAA receptor.
Bioorg Chem
; 103: 104182, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32890992
14.
Design, synthesis, and biological evaluation of novel dual PPARα/δ agonists for the treatment of T2DM.
Bioorg Chem
; 101: 103963, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32480174
15.
Discovery of novel dual PPARα/δ agonists based on benzimidazole scaffold for the treatment of non-alcoholic fatty liver disease.
Bioorg Chem
; 99: 103803, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32251945
16.
Synergistic Amplification of Oxidative Stress-Mediated Antitumor Activity via Liposomal Dichloroacetic Acid and MOF-Fe2.
Small
; 15(24): e1901156, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31074196
17.
Design, synthesis, and biological evaluation of novel dual FFA1 (GPR40)/PPARδ agonists as potential anti-diabetic agents.
Bioorg Chem
; 92: 103254, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31518760
18.
Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold.
Bioorg Chem
; 92: 103209, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31487621
19.
Synthesis and evaluation of anticonvulsant activities of 7-phenyl-4,5,6,7-tetrahydrothieno[3,2-b ]pyridine derivatives.
Arch Pharm (Weinheim)
; 352(10): e1900106, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31364202
20.
Synthesis and Evaluation of Antidepressant Activities of 5-Aryl-4,5-dihydrotetrazolo [1,5-a]thieno[2,3-e]pyridine Derivatives.
Molecules
; 24(10)2019 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31091808