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1.
Am J Otolaryngol ; 44(2): 103764, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36587603

RESUMO

OBJECTIVE: The pathophysiology of Meniere's Disease (MD) involves endolymphatic hydrops (ELH) of the inner ear. Magnetic Resonance Imaging (MRI) has been shown to detect ELH, but changes in ELH have been poorly described using this modality. Our objective was to review MRI-measured changes in ELH over time and after medical and/or surgical intervention in patients with MD. We secondarily aim to associate changes in ELH with changes in MD symptomatology. DATABASES REVIEWED: Medline, Web of Science, and Embase databases. METHODS: A systematic review of articles was performed to identify studies utilizing MRI to measure ELH changes over time, and after medical or surgical treatment. Articles on non-human subjects and without direct measurement of ELH were excluded. RESULTS: Of 532 studies identified, 12 were included, involving 170 patients (mean age 56.3 years). Ten studies were prospective; two were retrospective. Five studies strictly utilized medical means of intervention, four utilized surgical treatments, one utilized both, and two observed temporal changes without treatment. Across all interventions, 72.1 % of patients exhibited the same or worsening ELH on imaging. In studies reporting vertigo outcomes, 95.9 % of patients exhibited improvement after the treatment period. CONCLUSION: Medical and surgical interventions often yield symptomatic relief of vertigo in MD patients despite stable or increasing ELH volume. MRI may have greater clinical utility in diagnosing ELH as opposed to assessing treatment response.


Assuntos
Hidropisia Endolinfática , Doença de Meniere , Humanos , Estudos Retrospectivos , Estudos Prospectivos , Hidropisia Endolinfática/diagnóstico por imagem , Hidropisia Endolinfática/patologia , Doença de Meniere/complicações , Doença de Meniere/diagnóstico por imagem , Doença de Meniere/patologia , Vertigem , Imageamento por Ressonância Magnética/métodos
2.
Audiol Neurootol ; 26(5): 378-386, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33951634

RESUMO

INTRODUCTION: Cochlear implantation (CI) is a reliable and safe means by which sensorineural hearing loss can be ameliorated in the elderly population. However, a high degree of variation exists in postimplantation hearing outcomes for which some modifiable factors of the daily natural auditory environment may be contributory. In this study, we analyze the relationship between cochlear implant patient age, natural auditory environment, and postimplantation speech perception among older adults. METHODS: Data log from automatic environment classification enabled sound processors of postlingually deafened CI recipients ≥50 years old (n = 115) were obtained retrospectively and analyzed for time spent (hours per day) in listening environment and loudness (SPL dB). Speech perception testing was assessed in a subset of patients (n = 27) using open-set word recognition in quiet Consonant-Nucleus-Consonant in the short and intermediate postoperative period. RESULTS: The mean subject age was 70 years (range, 53-99 years). Average daily implant use was 10.8 h and was not significantly correlated with age (p = 0.23, Spearman's rho). Age was positively correlated with the percentage of hours spent at <40 and 40-50 dB and negatively correlated to proportional CI use at higher volume (60-70, 70-80, and >80 dB; rs = 0.21, 0.20, -0.20, -0.35, -0.43; p = 0.021, 0.036, 0.033, <0.001, <0.001, respectively). Age was positively correlated with CI use in the quiet scene (rs = 0.26, p = 0.006) and negatively correlated with scenes containing speech and noise (rs = -0.19, -0.25; p = 0.046, 0.007). Total hours of device use and time spent at <40, 40-50 dB, and quiet environments were significantly correlated with improved CNC word scores (rs = 0.48, 0.48, 0.51; p = 0.01, 0.01, <0.01, Spearman's rho). While all speech (speech in noise + speech) was not significantly correlated to improvements in speech perception, a medium effect size was observed (rs = 0.37, p = 0.057). DISCUSSION/CONCLUSION: This study supports a relationship between auditory environment and age, with older CI recipients spending a greater proportion of time in quiet. Older CI users demonstrated greater improvements in speech perception with longer daily device use. Additional examination of the relationship between auditory environment and speech perception is necessary to conclusively guide future auditory rehabilitation efforts.


Assuntos
Implante Coclear , Implantes Cocleares , Perda Auditiva Neurossensorial , Percepção da Fala , Idoso , Idoso de 80 Anos ou mais , Perda Auditiva Neurossensorial/cirurgia , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos
3.
Am J Otolaryngol ; 42(4): 102977, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33636684

RESUMO

OBJECTIVE: To describe a case of Burkitt lymphoma (BL) in a child manifesting with acute airway obstruction. To review available literature on the clinical features and characteristic presentation of this disease. METHODS: Case report with literature review. RESULTS: We present the case of an 8-year-old boy with nasopharyngeal BL manifesting initially as sore throat, nasal congestion, and snoring that progressed to dyspnea and, ultimately, acute airway obstruction requiring emergent tracheostomy. The child was treated with intensive chemotherapy and achieved complete response. CONCLUSION: This case highlights the importance of maintaining high clinical suspicion when evaluating common otolaryngologic symptoms and emphasizes the potential for Burkitt lymphoma to cause rapid patient deterioration.


Assuntos
Obstrução das Vias Respiratórias/etiologia , Obstrução das Vias Respiratórias/cirurgia , Linfoma de Burkitt/complicações , Linfoma de Burkitt/tratamento farmacológico , Neoplasias Nasofaríngeas/complicações , Neoplasias Nasofaríngeas/tratamento farmacológico , Traqueostomia/métodos , Doença Aguda , Obstrução das Vias Respiratórias/diagnóstico por imagem , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Linfoma de Burkitt/diagnóstico , Linfoma de Burkitt/diagnóstico por imagem , Criança , Ciclofosfamida/administração & dosagem , Doxorrubicina/administração & dosagem , Dispneia/diagnóstico por imagem , Dispneia/etiologia , Dispneia/cirurgia , Detecção Precoce de Câncer , Emergências , Humanos , Masculino , Metotrexato/administração & dosagem , Neoplasias Nasofaríngeas/diagnóstico , Neoplasias Nasofaríngeas/diagnóstico por imagem , Tomografia por Emissão de Pósitrons , Prednisona/administração & dosagem , Rituximab/administração & dosagem , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Vincristina/administração & dosagem
4.
Am J Otolaryngol ; 42(4): 102942, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33556837

RESUMO

OBJECTIVE: To discuss the utility of augmented reality in lateral skull base surgery. PATIENTS: Those undergoing lateral skull base surgery at our institution. INTERVENTION(S): Cerebellopontine angle tumor resection using an augmented reality interface. MAIN OUTCOME MEASURE(S): Ease of use, utility of, and future directions of augmented reality in lateral skull base surgery. RESULTS: Anecdotally we have found an augmented reality interface helpful in simulating cerebellopontine angle tumor resection as well as assisting in planning the incision and craniotomy. CONCLUSIONS: Augmented reality has the potential to be a useful adjunct in lateral skull base surgery, but more study is needed with large series.


Assuntos
Realidade Aumentada , Craniotomia/métodos , Neuroma Acústico/cirurgia , Procedimentos Neurocirúrgicos/métodos , Base do Crânio/cirurgia , Cirurgia Assistida por Computador/métodos , Humanos , Neuroma Acústico/diagnóstico por imagem , Base do Crânio/diagnóstico por imagem
5.
Am J Otolaryngol ; 41(5): 102562, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32563784

RESUMO

OBJECTIVE: To describe the utility and nuances of transcanal endoscopic surgery (TCES) on glomus tympanicum tumors from a single surgeon's experience. PATIENTS/INTERVENTION: Twelve patients, eight female and four males, diagnosed pre-operatively with glomus tympanicum tumors. They all underwent endoscopic resection by a single surgeon. MAIN OUTCOME MEASURES: Feasibility of endoscopic resection of glomus tympanicum tumors without conversion to a microscopic approach. Secondary outcomes include tumor stage, pre and post-operative audiometry, vertigo, sensorineural hearing loss (SNHL) and integrity of the facial nerve, ossicles, chorda tympani and tympanic membrane. RESULTS: Twelve patients underwent TCES, eight patient's pathology results were glomus tympanicum, ranging from Glasscock-Jackson grade I-III. Due to loss in follow up, 6/8 patients had complete audiometric data, which were analyzed. Average pre-operative air-bone-gap (ABG) was 5.41 compared to post-operative ABG of 5.08 (p > 0.89). No patients resulted in any, post-operative vertigo, tinnitus, SNHL, facial nerve injury or chorda tympani nerve injury. Two patients had intentional tympanic membrane perforations secondary to tumor adherence to the membrane. They were repaired with tragal perichondrium graft. No patients have had any recurrences. CONCLUSIONS: Endoscopic resection of glomus tympanicum tumors is a feasible and effective, alternative visualization modality for the neurotologist. Surgical pearls are described herein.


Assuntos
Neoplasias da Orelha/cirurgia , Endoscopia/métodos , Tumor de Glomo Timpânico/cirurgia , Procedimentos Cirúrgicos Otológicos/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento , Perfuração da Membrana Timpânica/etiologia , Perfuração da Membrana Timpânica/cirurgia
6.
Am J Otolaryngol ; 41(6): 102666, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32854042

RESUMO

PURPOSE: To assess the safety of using a microdrill in endoscopic vs microscopic stapes surgery. MATERIALS AND METHODS: A retrospective review of 29 adult ears with otosclerosis who underwent either an endoscopic or microscopic approach to microdrill stapedotomy. PRIMARY OUTCOME: Determine if transcanal endoscopic stapes surgery with the microdrill is as safe as microscopic stapes surgery. Secondary outcome: Bone and air pure-tone averages, air-bone gap, speech discrimination, overall surgical cost, and operative time were measured and analyzed. Complications such as post-operative dysgeusia, vertigo, readmission, revision and hearing loss were noted. RESULTS: 29 patients with otosclerosis were retrospectively reviewed, in total 14 endoscopic and 15 microscopic approaches were included, all performed over one-year period. None of the endoscopic surgeries require conversion to the microscope. No statistically significant audiometric differences between the endoscopic vs microscopic approaches in air pure-tone averages and air-bone gap. There were 82.8% air-bone gap closure to <15 dB with no significant difference in the percent of such closures between the endoscopic (85.7%) and microscopic groups (80%, P = .68). Three prostheses were used: 4.25 mm (17.2%), 4.5 mm (58.6%) and the 4.75 mm (24.1%) smart/eclipse. Endoscopic median operative time was 51 min vs 42 min for microscopic approach (P =.004). CONCLUSIONS: The endoscopic with microdrill approach is criticized to lack depth perception, especially when using a microdrill to perform in stapedotomies. Our study showcases that using the microdrill use produces minimal differences in outcomes, cost, and is a safe modality to stapes surgery in both approaches.


Assuntos
Endoscopia/instrumentação , Mandrillus , Microcirurgia/instrumentação , Otosclerose/cirurgia , Cirurgia do Estribo/instrumentação , Estribo , Animais , Endoscopia/métodos , Feminino , Humanos , Masculino , Microcirurgia/métodos , Pessoa de Meia-Idade , Duração da Cirurgia , Estudos Retrospectivos , Segurança , Cirurgia do Estribo/métodos , Resultado do Tratamento
8.
Am J Otolaryngol ; 40(3): 453-455, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30885448

RESUMO

Herein we present the rare case of angiolymphoid hyperplasia with eosinophilia of the external ear treated by surgical resection and full-thickness skin graft. Current diagnosis and management options are reviewed.


Assuntos
Hiperplasia Angiolinfoide com Eosinofilia/cirurgia , Otopatias/cirurgia , Orelha Externa , Procedimentos Cirúrgicos Otorrinolaringológicos/métodos , Procedimentos de Cirurgia Plástica/métodos , Hiperplasia Angiolinfoide com Eosinofilia/patologia , Otopatias/patologia , Feminino , Humanos , Pessoa de Meia-Idade , Transplante de Pele , Resultado do Tratamento
9.
Am J Otolaryngol ; 40(6): 102290, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31530434

RESUMO

PURPOSE: To determine the risk factors for unanticipated readmission, prolonged index admission, and discharge to a facility after vestibular schwannoma surgery. MATERIALS AND METHODS: Retrospective cohort study of those undergoing surgery for vestibular schwannoma in the Nationwide Readmissions Database (2013-2014). Main outcome measures included readmission rate, length of stay, discharge destination. RESULTS: There were 4585 cases identified. The overall unanticipated readmission rate was 8.1%, and 9.1% had a prolonged length of stay (PLOS) of ≥7 days. Mean and median LOS were 4.63 and 4.00 days, respectively, and >90% of patients were discharged after 7 days. Disposition to a facility occurred in 6.7% of cases. Teaching hospitals were protective against unintended readmission (odds ratio [OR] 0.44, p < .001). Major functional loss was associated with PLOS (OR 12.55, p < .001). High volume centers were associated with decreased risk of PLOS (OR 0.46, p < .001) and facility discharge (OR 0.68, p < .001). The most common readmission diagnoses included "other nervous system complications" (n = 128), cerebrospinal fluid leak (n = 71), "other postoperative infection" (n = 61), and meningitis (n = 59). CONCLUSIONS: Unanticipated readmission and prolonged LOS following vestibular schwannoma surgery are common, with varied sociodemographic, hospital, and patient factors independently associated with each. Further studies are needed to investigate targeted interventions aimed at minimizing readmission and prolonged LOS using the factors outlined above.


Assuntos
Tempo de Internação , Neuroma Acústico/cirurgia , Readmissão do Paciente , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Bases de Dados Factuais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Estados Unidos , Adulto Jovem
10.
Am J Otolaryngol ; 38(5): 526-528, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28532970

RESUMO

OBJECTIVE: To increase otolaryngology resident experience with drilling and dissection of the internal auditory canal (IAC) via a translabyrinthine approach. STUDY DESIGN: Pilot study involving temporal bone education and drilling with completion of pre- and post-drilling surveys. METHODS: Participants observed an educational presentation on IAC anatomy and drilling, followed by manipulation of IAC nerves using a prosected cadaveric temporal bone. Participants then drilled the IAC and identified nerves using temporal bones with previously drilled mastoidectomies and labyrinthectomies. Pre- and post-drilling 5-point Likert-based surveys were completed. RESULTS: 7 participants were included in this study ranging in experience from PGY1 through PGY 5. The median number of times the IAC had been drilled previously was 0. Participants reported statistically significantly improved familiarity with the translabyrinthine approach after the session with median scores increasing from 2 to 3 (p=0.02), and a near-significant increase in familiarity with IAC anatomy with median scores increasing from 3 to 4 (p=0.06). Prior to the session, 71% of participants either disagreed or strongly disagreed that they had an idea of what the procedure would be like in a real operating room, whereas after the session 0% reported disagreement. 100% of participants were very satisfied with the overall experience. CONCLUSIONS: An educational session and temporal bone drilling experience using prosected bones significantly increased the reported familiarity with the translabyrinthine approach. Experiences such as this may enhance resident exposure to advanced lateral skull base approaches in a safe environment, and increase comprehension of the complex anatomic relationships of the IAC.


Assuntos
Competência Clínica , Orelha Interna/cirurgia , Internato e Residência , Procedimentos Cirúrgicos Otológicos/educação , Cadáver , Currículo , Dissecação/educação , Feminino , Humanos , Masculino , Projetos Piloto , Osso Temporal/cirurgia
11.
Am J Otolaryngol ; 37(5): 452-4, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26732999

RESUMO

Cholesterol granuloma is the most common primary lesion of the petrous apex. Management of petrous apex cholesterol granuloma has evolved in recent years from primary surgical treatment to conservative observation. In this article, a case of spontaneous resolution of a petrous apex cholesterol granuloma is described. To the authors' knowledge, this is the first known report of spontaneous involution of a petrous apex cholesterol granuloma. Radiographic differential diagnosis of petrous apex lesions and the natural history of cholesterol granulomas are discussed.


Assuntos
Colesterol , Granuloma de Corpo Estranho/diagnóstico por imagem , Osso Petroso , Adolescente , Granuloma de Corpo Estranho/terapia , Humanos , Imageamento por Ressonância Magnética , Masculino , Remissão Espontânea , Conduta Expectante
12.
Am J Otolaryngol ; 37(3): 255-8, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27178519

RESUMO

OBJECTIVE: To evaluate radiographic tumor control and treatment-related toxicity in glomus jugulare tumors treated with stereotactic radiosurgery (SRS). STUDY DESIGN: Retrospective chart review. SETTING: Tertiary academic referral center. PATIENTS: Glomus jugulare tumors treated with SRS between 1998 and 2014 were identified. The data analysis only included patients with at least 18months of post-treatment follow up (FU). INTERVENTION: Patients were treated with either single fraction or fractionated SRS. MAIN OUTCOME MEASURE: Patient demographics and tumor characteristics were assessed. Radiographic control was determined by comparing pre and post treatment MRI, and was categorized as no change, regression, or progression. RESULTS: Eighteen patients were treated with SRS, and 14 met inclusion criteria. Median age at treatment was 55years (range 35-79), and 71.4% of patients were female. 5 patients (35.7%) received single fraction SRS (dose range 15-18Gy), and 9 (64.3%) fractionated therapy (dose 3-7Gy×3-15 fractions). Median tumor volume was 3.78cm(3) (range 1.15-30.6). Median FU was 28.8months (range 18.6-56.1), with a mean of 31.7months. At their last recorded MRI, 7 patients (50%) had tumor stability, 6 (42.9%) had improvement, and 1 (7.1%) had progression. Disease improvement and progression rates in the single fraction group were 40% and 0%, and in the multiple-fraction group, 44.4% and 11.1%, respectively. There was no statistically significant difference in disease improvement (p=0.88) or progression (p=0.48) rates between groups (unpaired t-test). CONCLUSIONS: At a median follow up of 28months, both single fraction and fractionated SRS appear to have comparable radiographic tumor control outcomes and toxicity profiles.


Assuntos
Tumor do Glomo Jugular/diagnóstico por imagem , Tumor do Glomo Jugular/terapia , Radiocirurgia , Adulto , Idoso , Fracionamento da Dose de Radiação , Feminino , Tumor do Glomo Jugular/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia , Estudos Retrospectivos , Resultado do Tratamento
13.
Audiol Neurootol ; 20(3): 183-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25896774

RESUMO

In this report, we used filtered noise bands to constrain listeners' access to interaural level differences (ILDs) and interaural time differences (ITDs) in a sound source localization task. The samples of interest were listeners with single-sided deafness (SSD) who had been fit with a cochlear implant in the deafened ear (SSD-CI). The comparison samples included listeners with normal hearing and bimodal hearing, i.e., with a cochlear implant in 1 ear and low-frequency acoustic hearing in the other ear. The results indicated that (i) sound source localization was better in the SSD-CI condition than in the SSD condition, (ii) SSD-CI patients rely on ILD cues for sound source localization, (iii) SSD-CI patients show functional localization abilities within 1-3 months after device activation and (iv) SSD-CI patients show better sound source localization than bimodal CI patients but, on average, poorer localization than normal-hearing listeners. One SSD-CI patient showed a level of localization within normal limits. We provide an account for the relative localization abilities of the groups by reference to the differences in access to ILD cues.


Assuntos
Implantes Cocleares , Perda Auditiva Unilateral/fisiopatologia , Localização de Som/fisiologia , Estimulação Acústica , Adulto , Sinais (Psicologia) , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
14.
Am J Otolaryngol ; 36(3): 475-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25701460

RESUMO

Primary middle ear neoplasms are rare, and commonly cause conductive hearing loss. When aural masses result in sensorineural hearing loss, malignant etiologies are often suspected. Fibroepithelial polyps are benign lesions commonly found in the skin and genitourinary tract and are not commonly identified as primary lesions of the middle ear. Here, we present a case of a benign fibroepithelial polyp of the middle ear causing sensorineural hearing loss and describe its surgical management. Imaging and histologic characteristics are reviewed.


Assuntos
Otopatias/patologia , Orelha Média , Perda Auditiva Neurossensorial/etiologia , Pólipos/patologia , Otopatias/complicações , Otopatias/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Pólipos/complicações , Pólipos/cirurgia
15.
Am J Otolaryngol ; 36(4): 578-82, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25929977

RESUMO

OBJECTIVE: To describe the incidence and management of patients with facial nerve stimulation (FNS) associated with cochlear implant (CI) use in the setting of a prior temporal bone fracture. PATIENTS: One adult CI recipient is reported who experienced implant associated FNS with a history of a temporal bone fracture. Additionally, a literature search was performed to identify similar patients from previous descriptions of CI related FNS. MAIN OUTCOME MEASURES: Presence of FNS after implantation and ability to modify implant programming to avoid FNS. RESULTS: The patient in the present report experienced FNS for middle and basal electrodes during intraoperative neural response telemetry (NRT) in the absence of any surgical exposure or manipulation of the facial nerve. FNS was absent during device activation, but it recurred during follow-up programming sessions. However, additional programming has prevented further FNS during regular implant use. Four other patients with FNS after temporal bone fracture were identified from the literature, and the present case represents the one of two cases in which reprogramming allowed for implant use without FNS. CONCLUSIONS: CI associated FNS is uncommon in patients with a history of a temporal bone fracture, but it is likely that fracture lines provide a lower impedance pathway to the adjacent facial nerve and thus reduce the threshold for FNS. The present report suggests that, in the setting of a prior temporal bone fracture, NRT is not always a reliable predictor of FNS during implant use, and programming changes can help to mitigate FNS when it occurs.


Assuntos
Implantes Cocleares , Doenças do Nervo Facial/terapia , Nervo Facial/fisiopatologia , Perda Auditiva Neurossensorial/etiologia , Fraturas Cranianas/complicações , Osso Temporal/lesões , Estimulação Elétrica Nervosa Transcutânea/métodos , Adulto , Doenças do Nervo Facial/etiologia , Perda Auditiva Neurossensorial/fisiopatologia , Perda Auditiva Neurossensorial/cirurgia , Humanos , Masculino , Fraturas Cranianas/diagnóstico por imagem , Osso Temporal/diagnóstico por imagem , Tomografia Computadorizada por Raios X
17.
Neurosurg Focus ; 36(1 Suppl): 1-2, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24380523

RESUMO

In this publication, video format is utilized to review the operative technique of retrosigmoid craniotomy for resection of acoustic neuroma with attempted hearing preservation. Steps of the operative procedure are reviewed and salient principles and technical nuances useful in minimizing complications and maximizing efficacy are discussed. The video can be found here: http://youtu.be/PBE5rQ7B0Ls .


Assuntos
Neoplasias Encefálicas/cirurgia , Craniotomia , Audição/fisiologia , Neuroma Acústico/cirurgia , Adulto , Neoplasias Encefálicas/diagnóstico , Tronco Encefálico/cirurgia , Craniotomia/métodos , Humanos , Masculino , Neuroma Acústico/diagnóstico , Resultado do Tratamento
18.
Ann Otol Rhinol Laryngol ; 123(4): 235-9, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24671478

RESUMO

OBJECTIVE: This study aimed to better identify factors associated with recurrence of squamous cell carcinoma (SCC) involving the temporal bone. METHODS: A retrospective study was conducted at a tertiary hospital. Sixty patients who were diagnosed over a 10-year period with SCC involving the temporal bone and underwent surgical resection were analyzed. All patients were staged based on the University of Pittsburgh staging system. Demographic, intraoperative, and pathologic data were analyzed with respect to recurrence. RESULTS: Thirteen (21.7%) patients were T1, 8 (13.3%) T2, 7 (11.7%) T3, and 32 (53.3%) T4. Eighteen patients (30.0%) recurred in the study period. The mean time to recurrence was 5.8 months. Tumors originating in the skin overlying the parotid gland and the external auditory canal had higher recurrence rates than those from the auricle/postauricular skin and temporal bone (P = .05). Direct parotid and perineural spread accounted for 15.0% of all routes of temporal invasion but resulted in 22.2% of all recurrences (P = .04). Increased N stage was statistically associated with increased risk of recurrence (P = .01). Cervical, as compared to perifacial and parotid, lymph node involvement was associated with increased risk of recurrence (odds ratio = 6.91; 95% confidence interval, 1.11-42.87). CONCLUSION: We have identified multiple factors that are associated with increased recurrence of SCC involving the temporal bone.


Assuntos
Carcinoma de Células Escamosas/patologia , Recidiva Local de Neoplasia/epidemiologia , Neoplasias Cranianas/patologia , Osso Temporal , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/epidemiologia , Carcinoma de Células Escamosas/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/terapia , Estadiamento de Neoplasias , Estudos Retrospectivos , Fatores de Risco , Neoplasias Cranianas/epidemiologia , Neoplasias Cranianas/terapia
19.
Am J Otolaryngol ; 35(2): 211-4, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24156886

RESUMO

Familial cerebral cavernoma is an autosomal dominant phenotype with incomplete clinical and neuroimaging penetrance. The most common clinical manifestations include seizures and cerebral hemorrhage. We present the case of a 7-year-old boy who developed acute onset facial nerve paralysis secondary to previously unknown familial cerebral cavernoma. Genetic workup revealed a KRIT1 gene deletion which was later confirmed in the patient's asymptomatic father and younger brother.


Assuntos
Neoplasias do Sistema Nervoso Central/complicações , Doenças do Nervo Facial/etiologia , Paralisia Facial/etiologia , Hemangioma Cavernoso do Sistema Nervoso Central/complicações , Doença Aguda , Repetição de Anquirina , Neoplasias do Sistema Nervoso Central/diagnóstico , Neoplasias do Sistema Nervoso Central/genética , Criança , Diagnóstico Diferencial , Doenças do Nervo Facial/diagnóstico , Paralisia Facial/diagnóstico , Deleção de Genes , Hemangioma Cavernoso do Sistema Nervoso Central/diagnóstico , Hemangioma Cavernoso do Sistema Nervoso Central/genética , Humanos , Proteína KRIT1 , Imageamento por Ressonância Magnética , Masculino , Proteínas Associadas aos Microtúbulos/genética , Linhagem , Fenótipo , Proteínas Proto-Oncogênicas/genética
20.
Am J Otolaryngol ; 35(3): 396-9, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24667058

RESUMO

OBJECTIVE: To demonstrate the added value of magnetic resonance imaging (MRI) over computed tomography (CT) during adult cochlear implant evaluation. PATIENTS: Two adult patients are discussed in whom MRI studies diagnosed bilateral vestibular schwannomas during cochlear implant candidacy evaluation. INTERVENTIONS: Temporal bone CT and MRI. MAIN OUTCOME MEASURE: Diagnosis of NF2. RESULTS: Two adult patients, ages 67 and 68 years, were evaluated for cochlear implant candidacy. Both patients experienced slowly progressive, bilateral hearing loss without complaints of vertigo, and neither patient had a family history of hearing loss or neurogenic tumors. Both patients had near-symmetric pure tone thresholds on audiometric testing. An MRI and a CT scan were performed on both patients, and bilateral vestibular schwannomas were identified on MRI. CONCLUSIONS: Though MRI is not routinely utilized in adult cochlear implant evaluation, it may be of greater clinical value than CT in the setting of adult-onset hearing loss. MRI allows for sensitive evaluation of cochlear patency and architecture, and cochlear nerve status. As demonstrated in the two index cases, MRI also provides the added benefit of evaluating for causes of retrocochlear hearing loss. These two patients would have likely experienced a significant delay in diagnosis of NF2 without preoperative MRI, particularly given the limitations of scanning following CI magnet placement.


Assuntos
Implantes Cocleares , Imageamento por Ressonância Magnética , Neuroma Acústico/diagnóstico , Tomografia Computadorizada por Raios X , Idoso , Humanos , Masculino , Vestíbulo do Labirinto
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