Quantum-enhanced nonlinear microscopy.

The performance of light microscopes is limited by the stochastic nature of light, which exists in discrete packets of energy known as photons. Randomness in the times that photons are detected introduces shot noise, which fundamentally constrains sensitivity, resolution and speed1. Although the long-established solution to this problem is to increase the intensity of the illumination light, this is not always possible when investigating living systems, because bright lasers can severely disturb biological processes2-4. Theory predicts that biological imaging may be improved without increasing light intensity by using quantum photon correlations1,5. Here we experimentally show that quantum correlations allow a signal-to-noise ratio beyond the photodamage limit of conventional microscopy. Our microscope is a coherent Raman microscope that offers subwavelength resolution and incorporates bright quantum correlated illumination. The correlations allow imaging of molecular bonds within a cell with a 35 per cent improved signal-to-noise ratio compared with conventional microscopy, corresponding to a 14 per cent improvement in concentration sensitivity. This enables the observation of biological structures that would not otherwise be resolved. Coherent Raman microscopes allow highly selective biomolecular fingerprinting in unlabelled specimens6,7, but photodamage is a major roadblock for many applications8,9. By showing that the photodamage limit can be overcome, our work will enable order-of-magnitude improvements in the signal-to-noise ratio and the imaging speed.

Waveguide-integrated chip-scale optomechanical magnetometer.

Optomechanical magnetometers enable highly sensitive magnetic field sensing. However, all such magnetometers to date have been optically excited and read-out either via free space or a tapered optical fiber. This limits their scalability and integrability, and ultimately their range of applications. Here, we present an optomechanical magnetometer that is excited and read-out via a suspended optical waveguide fabricated on the same silicon chip as the magnetometer. Moreover, we demonstrate that thermomechanical noise limited sensitivity is possible using portable electronics and laser. The magnetometer employs a silica microdisk resonator selectively sputtered with a magnetostrictive film of galfenol (FeGa) which induces a resonant frequency shift in response to an external magnetic field. Experimental results reveal the retention of high quality-factor optical whispering gallery mode resonances whilst also demonstrating high sensitivity and dynamic range in ambient conditions. The use of off-the-shelf portable electronics without compromising sensor performance demonstrates promise for applications.

Continuous Optical-to-Mechanical Quantum State Transfer in the Unresolved Sideband Regime.

Optical-to-mechanical quantum state transfer is an important capability for future quantum networks, quantum communication, and distributed quantum sensing. However, existing continuous state transfer protocols operate in the resolved sideband regime, necessitating a high-quality optical cavity and a high mechanical resonance frequency. Here, we propose a continuous protocol that operates in the unresolved sideband regime. The protocol is based on feedback cooling, can be implemented with current technology, and is able to transfer non-Gaussian quantum states with high fidelity. Our protocol significantly expands the kinds of optomechanical devices for which continuous optical-to-mechanical state transfer is possible, paving the way toward quantum technological applications and the preparation of macroscopic superpositions to test the fundamentals of quantum science.

Precision Magnetometers for Aerospace Applications: A Review.

Aerospace technologies are crucial for modern civilization; space-based infrastructure underpins weather forecasting, communications, terrestrial navigation and logistics, planetary observations, solar monitoring, and other indispensable capabilities. Extraplanetary exploration-including orbital surveys and (more recently) roving, flying, or submersible unmanned vehicles-is also a key scientific and technological frontier, believed by many to be paramount to the long-term survival and prosperity of humanity. All of these aerospace applications require reliable control of the craft and the ability to record high-precision measurements of physical quantities. Magnetometers deliver on both of these aspects and have been vital to the success of numerous missions. In this review paper, we provide an introduction to the relevant instruments and their applications. We consider past and present magnetometers, their proven aerospace applications, and emerging uses. We then look to the future, reviewing recent progress in magnetometer technology. We particularly focus on magnetometers that use optical readout, including atomic magnetometers, magnetometers based on quantum defects in diamond, and optomechanical magnetometers. These optical magnetometers offer a combination of field sensitivity, size, weight, and power consumption that allows them to reach performance regimes that are inaccessible with existing techniques. This promises to enable new applications in areas ranging from unmanned vehicles to navigation and exploration.

Proposal for a quantum traveling Brillouin resonator.

Brillouin systems operating in the quantum regime have recently been identified as a valuable tool for quantum information technologies and fundamental science. However, reaching the quantum regime is extraordinarily challenging, owing to the stringent requirements of combining low thermal occupation with low optical and mechanical dissipation, and large coherent phonon-photon interactions. Here, we propose an on-chip liquid based Brillouin system that is predicted to exhibit large phonon-photon coupling with exceptionally low acoustic dissipation. The system is comprised of a silicon-based "slot" waveguide filled with superfluid helium. This type of waveguide supports optical and acoustical traveling waves, strongly confining both fields into a subwavelength-scale mode volume. It serves as the foundation of an on-chip traveling wave Brillouin resonator with an electrostrictive single photon optomechanical coupling rate exceeding 240 kHz. Such devices may enable applications ranging from ultra-sensitive superfluid-based gyroscopes, to non-reciprocal optical circuits. Furthermore, this platform opens up new possibilities to explore quantum fluid dynamics in a strongly interacting condensate.

Mechanical Squeezing via Fast Continuous Measurement.

We revisit quantum state preparation of an oscillator by continuous linear position measurement. Quite general analytical expressions are derived for the conditioned state of the oscillator. Remarkably, we predict that quantum squeezing is possible outside of both the backaction dominated and quantum coherent oscillation regimes, relaxing experimental requirements even compared to ground-state cooling. This provides a new way to generate nonclassical states of macroscopic mechanical oscillators, and opens the door to quantum sensing and tests of quantum macroscopicity at room temperature.

Quantum noise limited nanoparticle detection with exposed-core fiber.

Label-free biosensors are important tools for clinical diagnostics and for studying biology at the single molecule level. The development of optical label-free sensors has allowed extreme sensitivity but can expose the biological sample to photodamage. Moreover, the fragility and complexity of these sensors can be prohibitive to applications. To overcome these problems, we develop a quantum noise limited exposed-core fiber sensor providing robust platform for label-free biosensing with a natural path toward microfluidic integration. We demonstrate the detection of single nanoparticles down to 25 nm in radius with optical intensities beneath known biophysical damage thresholds.

Free spectral range electrical tuning of a high quality on-chip microcavity.

Reconfigurable photonic circuits have applications ranging from next-generation computer architectures to quantum networks, coherent radar and optical metamaterials. Here, we demonstrate an on-chip high quality microcavity with resonances that can be electrically tuned across a full free spectral range (FSR). FSR tuning allows resonance with any source or emitter, or between any number of networked microcavities. We achieve it by integrating nanoelectronic actuation with strong optomechanical interactions that create a highly geometry-dependent effective refractive index. This allows low voltages and sub-nanowatt power consumption. We demonstrate a basic reconfigurable photonic network, bringing the microcavity into resonance with an arbitrary mode of a microtoroidal optical cavity across a telecommunications fibre link. Our results have applications beyond photonic circuits, including widely tuneable integrated lasers, reconfigurable optical filters for telecommunications and astronomy, and on-chip sensor networks.

Nondestructive Profilometry of Optical Nanofibers.

Single-mode optical nanofibers are a central component of a broad range of applications and emerging technologies. Their fabrication has been extensively studied over the past decade, but imaging of the final submicrometer products has been restricted to destructive or low-precision techniques. Here, we demonstrate an optical scattering-based scanning method that uses a probe nanofiber to locally scatter the evanescent field of a sample nanofibre. The method does not damage the sample nanofiber and is easily implemented by only using the same equipment as in a standard fiber-puller setup. We demonstrate the subnanometer radial resolution at video rates (0.7 nm in 10 ms) on single mode nanofibers, allowing for a complete high-precision profile to be obtained within minutes of fabrication. The method thus enables nondestructive, fast, and precise characterization of optical nanofibers, with applications ranging from optical sensors and cold atom traps to nonlinear optics.

High bandwidth on-chip capacitive tuning of microtoroid resonators.

We report on the design, fabrication and characterization of silica microtoroid based cavity opto-electromechanical systems (COEMS). Electrodes patterned onto the microtoroid resonators allow for rapid capacitive tuning of the optical whispering gallery mode resonances while maintaining their ultrahigh quality factor, enabling applications such as efficient radio to optical frequency conversion, optical routing and switching applications.

Interleukin-6 in combination with the interleukin-6 receptor stimulates glucose uptake in resting human skeletal muscle independently of insulin action.

AIM: To examine if the physiological concentrations of both interleukin-6 (IL-6), in combination with IL-6 receptor (IL-6R), are able to stimulate glucose uptake in human skeletal muscle and to identify the associated signalling pathways. METHODS: Skeletal muscle tissue (~60 mg) obtained from healthy female volunteers via muscle biopsy was subjected to incubation in the absence or presence of insulin (60 µU/ml), recombinant human IL-6 (rhIL-6) (4 ng/ml) or a combination of rhIL-6 (4 ng/ml) and rhIL-6R (100 ng/ml) for 30 min, with glucose transport measured for each incubation. Western blot analysis was conducted on key signalling proteins, protein kinase B (PKB/Akt), adenosine monophosphate kinase (AMPK) and mammalian target of rapamycin (mTOR) to gain an early insight into any differing transport mechanisms. RESULTS: Human skeletal muscle exhibited increased glucose uptake with insulin (1.85-fold; p < 0.05) and stimulated phosphorylation of PKB/Akt and AMPK (0.98 ± 0.23 and 1.49 ± 0.13, respectively, phosphorylated: total; p < 0.05). IL-6/IL-6R increased phosphorylation of mTOR (fourfold, p < 0.05) compared to insulin, IL-6 alone and basal control. IL-6 did not stimulate glucose uptake but combined with IL-6R, induced 1.5-fold increase in glucose uptake (p < 0.05) and phosphorylation of AMPK (0.95 ± 0.19; phosphorylated: total, p < 0.05). CONCLUSIONS: IL-6 in combination with IL-6R and not IL-6 alone increased glucose uptake in human skeletal muscle. IL-6/IL-6R-mediated glucose uptake occurred independently of PKB/Akt phosphorylation, showing that IL-6/IL-6R-induced glucose uptake is dependent on a divergent pathway.

A history of health and medical research in Australia.

Health and medical research has played an important role in improving the life of Australians since before the 20th century, with many Australian researchers contributing to important advances both locally and internationally. The establishment of the National Health and Medical Research Council (NHMRC) to support research and to work to achieve the benefits of research for the community was significant. The NHMRC has also provided guidance in research and health ethics. Australian research has broadened to include basic biomedical science, clinical medicine and science, public health and health services. In October 2002, the NHMRC adopted Indigenous health research as a strategic priority. In 2013, government expenditure through the NHMRC was $852.9 million. This article highlights some important milestones in the history of health and medical research in Australia.

Optical lock-in particle tracking in optical tweezers.

We demonstrate a lock-in particle tracking scheme in optical tweezers based on stroboscopic modulation of an illuminating optical field. This scheme is found to evade low frequency noise sources while otherwise producing an equivalent position measurement to continuous measurement. This was demonstrated to yield up to 20 dB of noise suppression at both low frequencies (< 1 kHz), where low frequency electronic noise was significant, and around 630 kHz where laser relaxation oscillations introduced laser noise. The setup is simple, and compatible with any trapping optics.

Ultrasensitive real-time measurement of dissipation and dispersion in a whispering-gallery mode microresonator.

We present the characterization of the recently developed cavity enhanced amplitude modulation laser absorption spectroscopy (CEAMLAS) technique to measure dissipation within the evanescent field of a whispering-gallery mode resonator, and demonstrate the parallel use of CEAMLAS and the Pound-Drever-Hall measurement techniques to provide both dissipation and dispersive real-time microresonator measurements. Using an atomic force microscope tip, we introduce a controlled perturbation to the evanescent field of the resonator. In this case, dissipative sensing allows up to 16.8 dB sensitivity improvement over dispersive measurements, providing the possibility for enhanced sensitivity in application such as biomolecule detection.

Quantum-enhanced micromechanical displacement sensitivity.

We report on a hitherto unexplored application of squeezed light: for quantum-enhancement of mechanical transduction sensitivity in microcavity optomechanics. Using a toroidal silica microcavity, we experimentally demonstrate measurement of the transduced phase modulation signal in the frequency range 4-5.8 MHz with a sensitivity -0.72(±0.01) dB below the shot noise level. This is achieved for resonant probing in the highly undercoupled regime, by preparing the probe in a weak coherent state with phase squeezed vacuum states at sideband frequencies.

Minimum requirements for feedback enhanced force sensing.

The problem of estimating an unknown force driving a linear oscillator is revisited. When using linear measurement, feedback is often cited as a mechanism to enhance bandwidth, sensitivity or resolution. We show that as long as the oscillator dynamics are known, there exists a real-time estimation strategy that reproduces the same measurement record as any arbitrary feedback protocol. Consequently some form of nonlinearity is required to gain any advantage beyond estimation alone. This result holds true in both quantum and classical systems, with nonstationary forces and feedback, and in the general case of non-Gaussian and correlated noise. Recently, feedback enhanced incoherent force resolution has been demonstrated [E. Gavartin, P. Verlot, and T. J. Kippenberg, Nat. Nano. 7, 509 (2012)], with the enhancement attributed to a feedback induced modification of the mechanical susceptibility. As a proof-of-principle, we experimentally reproduce this result through straightforward filtering.