Detalhe da pesquisa
1.
The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.
Blood
; 131(24): 2661-2669, 2018 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29724899
2.
Geospatial patterns of comorbidity prevalence among people with osteoarthritis in Alberta Canada.
BMC Public Health
; 20(1): 1551, 2020 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33059639
3.
Pharmacokinetic and Pharmacodynamic Considerations for Drugs Binding to Alpha-1-Acid Glycoprotein.
Pharm Res
; 36(2): 30, 2018 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30593605
4.
Implications for Metabolite Quantification by Mass Spectrometry in the Absence of Authentic Standards.
Drug Metab Dispos
; 45(5): 492-496, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28254953
5.
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Nat Chem Biol
; 11(6): 432-7, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25915199
6.
Mechanistic investigations into the species differences in pinometostat clearance: impact of binding to alpha-1-acid glycoprotein and permeability-limited hepatic uptake.
Xenobiotica
; 47(3): 185-193, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27160567
7.
Physiologically Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development.
Drug Metab Dispos
; 44(7): 934-43, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26936973
8.
Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor.
Xenobiotica
; 46(3): 268-77, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26294260
9.
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.
Blood
; 122(6): 1017-25, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23801631
10.
Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652.
Drug Metab Dispos
; 43(7): 936-43, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25887455
11.
Evaluation of drug-drug interactions for oncology therapies: in vitro-in vivo extrapolation model-based risk assessment.
Br J Clin Pharmacol
; 79(6): 946-58, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25443889
12.
Risk factors associated with human Rift Valley fever infection: systematic review and meta-analysis.
Trop Med Int Health
; 19(12): 1420-9, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25252137
13.
Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension.
Bioorg Med Chem Lett
; 24(20): 4812-7, 2014 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25248678
14.
Past residence outside of the United States is associated with diet quality in adults currently residing in the United States.
Am J Hum Biol
; 26(1): 64-72, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24155086
15.
Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.
Biopharm Drug Dispos
; 35(4): 237-52, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24415392
16.
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
J Med Chem
; 66(19): 13384-13399, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37774359
17.
In silico prediction of total human plasma clearance.
J Chem Inf Model
; 52(8): 2069-78, 2012 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22715914
18.
A validation of ground ambulance pre-hospital times modeled using geographic information systems.
Int J Health Geogr
; 11: 42, 2012 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23033894
19.
Rural-Urban Disparities in Realized Spatial Access to General Practitioners, Orthopedic Surgeons, and Physiotherapists among People with Osteoarthritis in Alberta, Canada.
Int J Environ Res Public Health
; 19(13)2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35805363
20.
Rural-Urban Differences in Non-Local Primary Care Utilization among People with Osteoarthritis: The Role of Area-Level Factors.
Int J Environ Res Public Health
; 19(11)2022 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35681975