Detalhe da pesquisa
1.
Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding.
J Biol Chem
; 299(11): 105328, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37806493
2.
Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells.
J Biol Chem
; 294(11): 4012-4026, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30635397
3.
Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.
J Chem Inf Model
; 60(11): 5457-5474, 2020 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32813975
4.
Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
ChemMedChem
; 18(8): e202200615, 2023 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36749883
5.
Extract2Chip-Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance.
Biosensors (Basel)
; 13(10)2023 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37887106
6.
Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors.
J Med Chem
; 66(13): 8666-8686, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37403966
7.
In-depth biophysical analysis of interactions between therapeutic antibodies and the extracellular domain of the epidermal growth factor receptor.
Anal Biochem
; 421(1): 138-51, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22085444
8.
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.
Bioorg Med Chem Lett
; 22(13): 4396-403, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22632933
9.
Colocalized targeting of TGF-ß and PD-L1 by bintrafusp alfa elicits distinct antitumor responses.
J Immunother Cancer
; 10(7)2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35858707
10.
Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models.
J Med Chem
; 64(14): 10371-10392, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34255518
11.
Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology.
J Med Chem
; 64(16): 11904-11933, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34382802
12.
Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer.
J Med Chem
; 62(24): 11119-11134, 2019 12 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31725285
13.
Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases.
J Med Chem
; 62(17): 7643-7655, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31368705
14.
Probing the sensory rhodopsin II binding domain of its cognate transducer by calorimetry and electrophysiology.
J Mol Biol
; 330(5): 1203-13, 2003 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-12860139
15.
Functional analysis of Hsp70 inhibitors.
PLoS One
; 8(11): e78443, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24265689
16.
Structural and biophysical characterization of the Syk activation switch.
J Mol Biol
; 425(2): 309-33, 2013 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23154170
17.
Sulfur as the key element for quantitative protein analysis by capillary liquid chromatography coupled to element mass spectrometry.
Angew Chem Int Ed Engl
; 42(29): 3425-7, 2003 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-12888976
18.
Analysis of CheA histidine phosphorylation and its influence on protein stability by high-resolution element and electrospray mass spectrometry.
Anal Chem
; 77(7): 1957-62, 2005 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15801724
19.
Structural analysis of a HAMP domain: the linker region of the phototransducer in complex with sensory rhodopsin II.
J Biol Chem
; 280(46): 38767-75, 2005 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-16157581
20.
Time-resolved FTIR studies of sensory rhodopsin II (NpSRII) from Natronobacterium pharaonis: implications for proton transport and receptor activation.
Biophys J
; 84(2 Pt 1): 1208-17, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12547800