Detalhe da pesquisa
1.
Quantitation of soluble aggregates by sedimentation velocity analytical ultracentrifugation using an optical alignment system - Aspects of method validation.
Anal Biochem
; 605: 113837, 2020 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32702436
2.
An optical alignment system improves precision of soluble aggregate quantitation by sedimentation velocity analytical ultracentrifugation.
Anal Biochem
; 531: 16-19, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28529050
3.
Estimating analytical variability in two-dimensional data.
Anal Biochem
; 513: 36-38, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27567991
4.
High-throughput analysis of concentration-dependent antibody self-association.
Biophys J
; 101(7): 1749-57, 2011 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21961601
5.
Computational design and biophysical characterization of aggregation-resistant point mutations for γD crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity.
Biochemistry
; 50(5): 628-39, 2011 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21184609
6.
Molecular level insights into thermally induced α-chymotrypsinogen A amyloid aggregation mechanism and semiflexible protofibril morphology.
Biochemistry
; 49(49): 10553-64, 2010 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21067192
7.
Understanding the Increased Aggregation Propensity of a Light-Exposed IgG1 Monoclonal Antibody Using Hydrogen Exchange Mass Spectrometry, Biophysical Characterization, and Structural Analysis.
J Pharm Sci
; 107(6): 1498-1511, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29408480
8.
Nonnative protein polymers: structure, morphology, and relation to nucleation and growth.
Biophys J
; 93(12): 4392-403, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17704182
9.
Variability in Flow-Imaging Microscopy Measurements and Considerations for Biopharmaceutical Development.
J Pharm Sci
; 105(11): 3296-3303, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27663382
10.
Technical Decision Making With Higher Order Structure Data: Perspectives on Higher Order Structure Characterization From the Biopharmaceutical Industry.
J Pharm Sci
; 105(12): 3465-3470, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27743675
11.
Technical decision-making with higher order structure data: starting a new dialogue.
J Pharm Sci
; 104(4): 1240-5, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25711138
12.
Technical decision-making with higher order structure data: specific binding of a nonionic detergent perturbs higher order structure of a therapeutic monoclonal antibody.
J Pharm Sci
; 104(4): 1543-7, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25545760
13.
Arrhenius time-scaled least squares: a simple, robust approach to accelerated stability data analysis for bioproducts.
J Pharm Sci
; 103(8): 2278-86, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24974956
14.
Reduction of the C191-C220 disulfide of α-chymotrypsinogen A reduces nucleation barriers for aggregation.
Biophys Chem
; 185: 79-87, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24374388
15.
Aggregation and pH-temperature phase behavior for aggregates of an IgG2 antibody.
J Pharm Sci
; 101(5): 1678-87, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22246657
16.
Characterization of high-molecular-weight nonnative aggregates and aggregation kinetics by size exclusion chromatography with inline multi-angle laser light scattering.
J Pharm Sci
; 98(11): 3997-4016, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19283773
17.
Principles, approaches, and challenges for predicting protein aggregation rates and shelf life.
J Pharm Sci
; 98(4): 1246-77, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18683878
18.
Nucleation, growth, and activation energies for seeded and unseeded aggregation of alpha-chymotrypsinogen A.
Biochemistry
; 47(8): 2397-403, 2008 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-18215071