Detalhe da pesquisa
1.
Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses.
Mol Cell Neurosci
; 102: 103449, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31770590
2.
Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition.
Circulation
; 138(18): 1974-1987, 2018 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30030415
3.
Gestational stress in mouse dams negatively affects gestation and postpartum hippocampal BDNF and P11 protein levels.
Mol Cell Neurosci
; 88: 292-299, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29501719
4.
Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications.
Int J Neuropsychopharmacol
; 19(10)2016 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27037577
5.
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.
Nature
; 467(7311): 95-8, 2010 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20811458
6.
Discovery of novel alpha7 nicotinic receptor antagonists.
Bioorg Med Chem Lett
; 20(16): 4825-30, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20638843
7.
Synthesis and antiproliferative activity of 7-azaindirubin-3'-oxime, a 7-aza isostere of the natural indirubin pharmacophore.
J Nat Prod
; 72(12): 2199-202, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19994845
8.
Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition.
Cell Signal
; 62: 109338, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31176021
9.
Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction.
Adv Neurobiol
; 17: 349-384, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28956339
10.
Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats.
Psychopharmacology (Berl)
; 233(17): 3113-24, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27342643
11.
Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases.
J Med Chem
; 59(3): 1149-64, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26789933
12.
Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation.
FEBS Lett
; 579(2): 464-8, 2005 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15642359
13.
Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission.
Psychopharmacology (Berl)
; 232(3): 605-21, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25120104
14.
Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.
J Med Chem
; 57(6): 2670-82, 2014 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24559051
15.
Nerve agent exposure elicits site-specific changes in protein phosphorylation in mouse brain.
Brain Res
; 1342: 11-23, 2010 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20423708
16.
The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding.
J Biol Chem
; 282(5): 2911-7, 2007 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17135270
17.
Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.
Genomics
; 81(2): 112-25, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12620389
18.
Backbone resonance assignment of the 298 amino acid catalytic domain of protein tyrosine phosphatase 1B (PTP1B).
J Biomol NMR
; 24(2): 165-6, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12495035