Detalhe da pesquisa
1.
Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the ß2 adrenergic receptor.
EMBO J
; 35(12): 1330-45, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27103070
2.
Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.
Proc Natl Acad Sci U S A
; 114(42): 11229-11234, 2017 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28973916
3.
Loss of ß-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure.
Proc Natl Acad Sci U S A
; 113(49): E7976-E7985, 2016 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27864509
4.
K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome.
Proc Natl Acad Sci U S A
; 113(24): 6773-8, 2016 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27247394
5.
Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.
Nature
; 489(7416): 385-90, 2012 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22914087
6.
Basal and ß-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700.
Proc Natl Acad Sci U S A
; 111(46): 16598-603, 2014 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25368181
7.
Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome.
Proc Natl Acad Sci U S A
; 111(30): E3139-48, 2014 Jul 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-25024183
8.
PDE4B mediates local feedback regulation of ß1-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes.
J Cell Sci
; 127(Pt 5): 1033-42, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24413164
9.
Dissecting the phenotypes of Dravet syndrome by gene deletion.
Brain
; 138(Pt 8): 2219-33, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26017580
10.
Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response.
Proc Natl Acad Sci U S A
; 110(48): 19621-6, 2013 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24218620
11.
Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.
Neurobiol Dis
; 73: 106-17, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25281316
12.
Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome.
Neurobiol Dis
; 77: 141-54, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25766678
13.
Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation.
Proc Natl Acad Sci U S A
; 109(42): 17099-104, 2012 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23035250
14.
Structural basis for gating charge movement in the voltage sensor of a sodium channel.
Proc Natl Acad Sci U S A
; 109(2): E93-102, 2012 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22160714
15.
Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome.
Proc Natl Acad Sci U S A
; 109(36): 14646-51, 2012 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22908258
16.
Ca2+-independent activation of Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain of CaV2.1 calcium channels.
J Biol Chem
; 288(7): 4637-48, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23255606
17.
Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry.
J Mol Cell Cardiol
; 64: 69-78, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23982034
18.
Distribution and function of sodium channel subtypes in human atrial myocardium.
J Mol Cell Cardiol
; 61: 133-141, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23702286
19.
Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo.
J Biol Chem
; 286(14): 12617-26, 2011 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21216955
20.
Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels.
Circ Res
; 107(6): 747-56, 2010 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-20671242