Detalhe da pesquisa
1.
pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery.
Mol Pharm
; 9(5): 1199-212, 2012 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22489626
2.
Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X7 receptor.
Bioorg Med Chem Lett
; 21(18): 5475-9, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782426
3.
Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.
Bioorg Med Chem Lett
; 21(12): 3708-11, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21565499
4.
The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia.
Eur J Pharmacol
; 582(1-3): 154-61, 2008 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-18242596
5.
Development of a new permeability assay using low-efflux MDCKII cells.
J Pharm Sci
; 100(11): 4974-85, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21766308