Detalhe da pesquisa
1.
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.
Nat Chem Biol
; 17(10): 1065-1074, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34168367
2.
Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.
Nat Chem Biol
; 17(11): 1209, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34616097
3.
Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.
Nat Chem Biol
; 17(8): 925, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34188221
4.
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
Cancer Discov
; 14(6): 994-1017, 2024 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38593348
5.
Sampling the N-terminal proteome of human blood.
Proc Natl Acad Sci U S A
; 107(10): 4561-6, 2010 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20173099
6.
Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J Med Chem
; 66(1): 149-169, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36533617
7.
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS.
Science
; 381(6659): 794-799, 2023 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37590355
8.
Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma.
bioRxiv
; 2023 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38105998
9.
Efficacy of a Novel Bi-Steric mTORC1 Inhibitor in Models of B-Cell Acute Lymphoblastic Leukemia.
Front Oncol
; 11: 673213, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34408976
10.
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Front Immunol
; 11: 576310, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33133093
11.
Allosteric Inhibition of SHP2 Stimulates Antitumor Immunity by Transforming the Immunosuppressive Environment.
Cancer Res
; 80(13): 2889-2902, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32350067
12.
RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers.
Nat Cell Biol
; 20(9): 1064-1073, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30104724
13.
Native state energetics of the Src SH2 domain: evidence for a partially structured state in the denatured ensemble.
Protein Sci
; 15(7): 1769-79, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16751610
14.
On the precision of experimentally determined protein folding rates and phi-values.
Protein Sci
; 15(3): 553-63, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16501226
15.
Hydrogen exchange and ligand binding: ligand-dependent and ligand-independent protection in the Src SH3 domain.
Protein Sci
; 14(1): 81-8, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15576569
16.
Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins.
Protein Sci
; 14(3): 602-16, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15689503
17.
Hydrogen-exchange strategies applied to energetics of intermediate processes in protein folding.
Methods Enzymol
; 380: 328-49, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15051344