Combination of multichannel single-voxel MRS signals using generalized least squares.

PURPOSE: To propose using the generalized least square (GLS) algorithm for combining multichannel single-voxel magnetic resonance spectroscopy (MRS) signals. MATERIALS AND METHODS: Phantom and in vivo brain MRS experiments on a 7 T scanner equipped with a 32-channel receiver coil, as well as Monte Carlo simulations, were performed to compare the coefficient of variation (CV) of the GLS method with those of two recently reported spectral combination methods. RESULTS: Compared to the two existing methods, the GLS method significantly reduced CV values for the simulation, phantom, and in vivo experiments. CONCLUSION: The GLS method can lead to improved precision of peak quantification.