Impact of race and ethnicity on outcomes after autologous stem cell transplantation for patients with newly diagnosed multiple myeloma.

Non-Hispanic Black patients are disproportionally affected by multiple myeloma (MM) and whether efficacy outcomes after autologous stem cell transplant (ASCT) differ by race and ethnicity remains an area of active investigation. This study included 449 patients enriched with a large proportion of non-Hispanic Black patients and sought to highlight the impact of race and ethnicity on outcomes after HDT-ASCT for patients with newly diagnosed MM. We found induction chemotherapy followed by high-dose therapy-ASCT and maintenance chemotherapy is associated with long-term PFS and OS, regardless of race or ethnicity.

Creating a community-based comprehensive intervention to improve asthma control in a low-income, low-resourced community.

Introduction: Asthma evidence-based interventions (EBI) are implemented in the home, school, community or primary care setting. Although families are engaged in one setting, they often have to navigate challenges in another setting.Objective: Our objective is to design and implement a comprehensive plan which integrates EBI's and connects the four sectors in underserved communities such as Philadelphia.Methods: September 2015-April 2016 we implemented a three-pronged strategy to understand needs and resources of the community including 1) focus groups and key informant interviews, 2) secondary data analysis and 3) pilot testing for implementation to determine gaps in care, and opportunities to overcome those gaps.Results: Analysis of the focus group and key informant responses showed themes: diagnosis fear, clinician time, home and school asthma trigger exposures, school personnel training and communication gaps across all four sectors. EBI's were evaluated and selected to address identified themes. Pilot testing of a community health worker (CHW) intervention to connect home, primary care and school resulted in an efficient transfer of asthma medications and medication administration forms to the school nurse office for students with uncontrolled asthma addressing a common delay leading to poor asthma management in school.Conclusion: Thus far there has been limited success in reducing asthma disparities for low-income minority children. This study offers hope that strategically positioning CHWs may work synergistically to close gaps in care and result in improved asthma control and reduced asthma disparities.

The West Philadelphia asthma care implementation study (NHLBI# U01HL138687).

Asthma is the most common chronic condition among children, with low-income families living in urban areas experiencing significantly higher rates. Evidence based interventions for asthma are routinely implemented in either the home, school, or primary care setting. However, even when caregivers of poor children are engaged in asthma interventions in one setting, they often have to navigate challenges in another setting, such as an under-resourced home, non-supportive school, or disengaged health care provider. The West Philadelphia Asthma Care Implementation Plan aims to compare the effectiveness of a primary care-based intervention, school-based intervention, and combined primary care and school intervention to usual care for improving asthma control in school-age children to explore if the synergistic effect of Community Health Worker (CHW) support in the home, school, and health care environments will result in improved asthma control. Children ages 5-13 with uncontrolled asthma from four West Philadelphia recruitment sites will be eligible for enrollment. The families of school age children interested in participating will be randomized to receive a primary care CHW or usual care. Those identified as attending a participating school will have a CHW-led school intervention or usual care in school. If proven effective, this care coordination program will assist caregivers in assessing resources, improving self-management skills, and ultimately reducing asthma-related ED visits and hospitalizations as well as provide additional information for healthcare systems and policy makers to inform their decisions about how and where to focus additional resources and investments in childhood asthma care to improve health outcomes.

Lobeline Effects on Cognitive Performance in Adult ADHD.

OBJECTIVE: In preclinical studies, lobeline inhibited hyperactivity induced by nicotine and amphetamine, and improved performance and learning in studies utilizing radial-arm maze and spatial-discrimination water maze. This laboratory proof-of-concept study investigated lobeline as a treatment for ADHD symptoms in adults (31.11 ± 7.08 years). METHOD: Using cognitive tasks and self-report measures, the effects of lobeline (0, 7.5, 15, or 30 mg, s.l.) and methylphenidate (0, 15, or 30 mg, p.o.) were assessed in nine volunteers with ADHD. RESULTS: Evidence suggested that lobeline could modestly improve working memory in adults with ADHD, but no significant improvement in attention was observed. Lobeline administration was associated with mild adverse side effects (nausea). CONCLUSION: Further investigation of lobeline on working memory may be warranted.

Experiencia formativa de académicos en dos universidades latinas en diplomado de simulación clínica en enfermería / Training Experience with Scholars from two Latin-American Universities during a Diploma Course in Nursing Clinical Simulation

Introducción: Capacitar en simulación clínica asegura calidad de la enseñanza e incrementa conocimientos necesarios para realizar procesos dinámicos que involucren creación de entornos hipotéticos de representaciones auténticas de realidades sanitarias. Esta estrategia reviste importancia para concretar productos e insumos derivados de entrenamientos en simulación, ligados a satisfacción de profesionales que finalizan estas experiencias formativas. Objetivo: Conocer la satisfacción general de académicos y el producto obtenido de una experiencia formativa en modalidad de diplomado en simulación clínica de alta fidelidad. Métodos: Estudio descriptivo, de corte trasversal, con análisis teórico-lógico-reflexivo desde la literatura que respaldó el diseño didáctico del proyecto. Se trabajó con la totalidad de académicos de la Facultad de Enfermería, Universidad de Panamá (N = 146), durante mayo-julio del 2022. Hubo clases sincrónicas y asincrónicas y una semana presencial para exposiciones de escenarios. Se evaluó la estrategia con cuestionario de cinco dimensiones validado por criterios de jueces. El puntaje Alfa de Cronbach final fue 0,89. Se incluyeron profesores con más de 92 por ciento de asistencia a clases, los que tuvieron conexiones inestables a encuentros se excluyeron. Se realizó análisis estadístico descriptivo en programa SPSS. Se siguieron normas éticas y recomendaciones para estudios con seres humanos. Resultados: El 99 por ciento evaluó la capacitación con nivel de satisfacción muy alto. Se obtuvieron productos clave, como reglamentos, consentimientos informados y banco de escenarios validados, como insumos de trabajo para la facultad. Conclusiones: Los resultados configuraron respuestas de un grupo de académicos capacitados en simulación clínica, con valoración de muy alta satisfacción. Los productos obtenidos se encaminaron a normativas y guías para uso de simulación(AU)

Introduction: Clinical simulation training ensures the quality of teaching and increases the knowledge necessary to carry out dynamic processes involving the creation of hypothetical environments of authentic representations of health realities. This strategy is important for the realization of products and inputs derived from simulation training, linked to the satisfaction of professionals who complete these training experiences. Objective: To know the general satisfaction of scholars and the product obtained from a training experience as a diploma course in high-fidelity clinical simulation. Methods: A descriptive and cross-sectional study was carried out, following a theoretical-logical-reflexive analysis from the literature, which supported the didactic design of the project. The working methodology included all the scholars from the Nursing School at University of Panama (N=146), during May-July 2022. There were synchronous and asynchronous classes, as well as a face-to-face week for scenario presentations. The strategy was evaluated with a five-dimension questionnaire validated by judges' criteria. The final Cronbach's alpha score was 0.89. Professors with more than 92 percent of class attendance were included; those with unstable connections to meetings were excluded. A descriptive statistical analysis was performed in the SPSS software. Ethical norms and recommendations for studies with human beings were followed. Results: 99 percent assessed the training with a very high level of satisfaction. Key products were obtained, such as regulations, informed consents and a stock of validated scenario, as working inputs for the school. Conclusions: The outcomes included responses from a group of scholars trained in clinical simulation, with very high satisfaction ratings. The products obtained were directed towards regulations and guidelines for the use of simulation(AU)

The association between adult drug abuse and childhood maltreatment in students attending seven universities in five countries in Latin America and one country in the Caribbean / A associacao entre o abuso de drogas e o maltrato infantil em estudantes de sete universidades de cinco paises da América Latina e um do Caribe / La asociacion entre el abuso de drogas y el maltrato infantil en estudiantes de siete uniersidades de cinco paises de Latin America y uno pais del Caribe

This study investigated the relationship between childhood maltreatment and adulthood drug abuse among university students from seven universities in five countries in Latin America and one country in the Caribbean. This multi-country study utilised a cross-sectional design to collect data on drug abuse, as well as retrospective data on maltreatment during childhood. The sample consisted of 2,283 university students, of which 82.6% reported childhood maltreatment experiences, and 33.5% increased levels of psychological distress. A significant relationship was observed between childhood maltreatment and drug abuse as an adult (p<0.05). Although the sampling technique does not permit generalisations to all university students, the current study identified exposure to childhood maltreatment as a potential precursor to adult drug abuse within the populations studied. Therefore, the effectiveness of drug demand reduction strategies at the respective universities may be enhanced by incorporating policies and interventions aimed at childhood maltreatment.

Este estudo busca identificar a relação entre o maltrato durante a infância e o abuso de drogas entre estudantes de sete universidades em cinco países de America Latina e um país do Caribe. Este é um estudo feito em vários países, utilizando um desenho de corte para coletar os dados de abuso de drogas e um levantamento retrospectivo sobre o maltrato na infância. A amostra foi constituída de 2.283 estudantes universitários, dos quais 82,6% informaram terem sido maltratadas na infância e 33,5% informaram ter níveis elevados de distresse psicológicos. Os dados indicaram uma relação significante (p<0.05) entre maltrato na infância e o abuso de drogas na vida adulta. Apesar da técnica amostral não permitir generalização para a população de estudantes, universitários, o presente estudo identificou que a exposição ao maltrato durante a infância e um precursor potencial para o abuso de drogas na vida adulta nesta população. Portanto, estratégias para reduzir o consumo de drogas entre as respectivas universidades podem melhorar sua efetividade se incorporarem políticas e intervenções que levam em consideração o aspecto de maltrato na infância.

Este estudio busca identificar la relación entre el maltrato durante la infancia y el abuso de drogas entre estudiantes de siete Universidad en cinco países de Latin America y uno país del Caribe. Este es un estudio hecho en varios países utilizando un diseño de corte para colectar los datos del abuso de drogas y un levantamiento retrospectivo sobre el maltrato en la infancia. La muestra fue constituida de 2.283 estudiantes universitarios, de los cuales 82,6% informaran maltrato en la infancia, y 33,5% informaran ter niveles elevados de distress psicológicos. Los datos indicaran una relación significante (p<0.05) entre el maltrato en la infancia y el abuso de drogas en la vida adulta. A pesar de la técnica amuéstrale no permitir generalización para la población de estudiantes universitarios, el presente estudio identifico que la exposición al maltrato durante la infancia es un precursor potencial para el abuso de drogas durante la vida adulta. Por lo tanto, estrategias para reducir el consume de drogas entre las respectivas universidades poden mejorar su efectividad si incorporan políticas e intervenciones que llevan en consideración el aspecto del maltrato en la infancia.