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1.
J Assoc Med Microbiol Infect Dis Can ; 7(3): 269-278, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36337597

RESUMO

BACKGROUND: Sternal osteomyelitis caused by Aspergillus spp is uncommon in cardiac surgery patients requiring sternotomy. CASE PRESENTATION: We report a 77-year-old male with a history of poorly controlled diabetes who was diagnosed with Aspergillus sternal osteomyelitis, three months following an uneventful coronary artery bypass surgery. He underwent multiple debridement surgeries and was treated with voriconazole. Despite a complicated post-operative course, the patient responded well to voriconazole with clinical and biochemical evidence of remission. Unfortunately, he died of an unrelated cause due to decompensated heart failure. DISCUSSION: Though uncommon, Aspergillus sternal osteomyelitis should be considered in the differential diagnosis of immunocompetent patients with post-operative sternal wound infections and negative bacterial tissue cultures. Management should include a combination of medical and surgical therapy.


HISTORIQUE: L'ostéomyélite sternale causée par des espèces d'Aspergillus est rare chez les patients en chirurgie cardiaque qui ont besoin d'une sternotomie. PRÉSENTATION DE CAS: Les chercheurs présentent le cas d'un homme de 77 ans ayant des antécédents de diabète mal contrôlé qui a obtenu un diagnostic d'ostéomyélite sternale à Aspergillus trois mois après un pontage aortocoronarien sans histoire. Il a subi de multiples opérations de débridement et a reçu un traitement au voriconazole. Malgré une évolution postopératoire complexe, il a bien répondu au voriconazole et a obtenu des résultats cliniques et biochimiques de rémission. Malheureusement, il est décédé d'une décompensation cardiaque non apparentée. DISCUSSION: Bien qu'elle soit rare, l'ostéomyélite sternale à Aspergillus devrait faire partie du diagnostic différentiel des patients immunocompétents présentant une infection postopératoire de la plaie sternale et des cultures tissulaires bactériennes négatives. La prise en charge doit inclure un traitement médical et chirurgical associé.

2.
Open Forum Infect Dis ; 8(10): ofab451, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34631919

RESUMO

Prosthetic joint infection caused by Mycobacterium tuberculosis (TBPJI) is uncommon but can be encountered in immunocompromised patients or those from tuberculosis-endemic regions. A lack of clinical suspicion and experience with TBPJI often leads to a delay in diagnosis. We report 2 cases of TBPJI in a Hungarian-Canadian and Iranian-Canadian immigrant, respectively. Both were treated with concurrent surgical and medical therapy. We also performed a literature review on TBPJI case reports, outlining their diagnosis and management.

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