Detalhe da pesquisa
1.
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™.
Int J Toxicol
; 41(4): 276-290, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35603517
2.
An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation.
Int J Toxicol
; 39(4): 274-293, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32406289
3.
A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium.
Int J Toxicol
; 38(1): 23-32, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30567462
4.
Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.
Bioorg Med Chem Lett
; 27(15): 3353-3358, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28610977
5.
Cellular and functional actions of tofacitinib related to the pathophysiology of hibernoma development.
Regul Toxicol Pharmacol
; 91: 93-102, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29074274
6.
Hemodynamic correlates of drug-induced vascular injury in the rat using high-frequency ultrasound imaging.
Toxicol Pathol
; 42(4): 784-91, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24670818
7.
A comparison of activity data generated from cardiovascular telemetry studies - With quantitative open field locomotor studies in Wistar Han rats.
J Pharmacol Toxicol Methods
; 119: 107208, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-35944806
8.
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute.
J Pharmacol Toxicol Methods
; 121: 107265, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36997076
9.
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As.
J Pharmacol Toxicol Methods
; 123: 107270, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37164235
10.
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis.
J Pharmacol Toxicol Methods
; 121: 107266, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36963703
11.
Improved preclinical cardiovascular therapeutic indices with long-term inhibition of norepinephrine reuptake using reboxetine.
Toxicol Appl Pharmacol
; 264(3): 343-50, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23000177
12.
Use of high throughput ion channel profiling and statistical modeling to predict off-target arrhythmia risk - One pharma's experience and perspective.
J Pharmacol Toxicol Methods
; 118: 107213, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36084863
13.
The Challenges of Predicting Drug-Induced QTc Prolongation in Humans.
Toxicol Sci
; 187(1): 3-24, 2022 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35148401
14.
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Clin Pharmacol Ther
; 109(2): 310-318, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32866317
15.
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.
Clin Pharmacol Ther
; 107(1): 102-111, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31709525
16.
Preclinical to Clinical Translation of Hemodynamic Effects in Cardiovascular Safety Pharmacology Studies.
Toxicol Sci
; 169(1): 272-279, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30726989
17.
Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment.
J Pharmacol Toxicol Methods
; 128: 107515, 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38777240
18.
Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium.
Br J Pharmacol
; 175(4): 606-617, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29181850
19.
Cardiac sodium channel antagonism - Translation of preclinical in vitro assays to clinical QRS prolongation.
J Pharmacol Toxicol Methods
; 89: 9-18, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29042254
20.
Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants.
J Pharmacol Toxicol Methods
; 55(1): 78-85, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-16678449