Detalhe da pesquisa
1.
Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib.
Drug Metab Dispos
; 50(9): 1170-1181, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35779865
2.
Endoscopic nodal staging in oligometastatic non-small cell lung cancer (NSCLC) being treated with stereotactic ablative radiotherapy (ENDO-SABR).
BMC Cancer
; 22(1): 468, 2022 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35484614
3.
Exposure-Effect Relationships in Established Rat Adjuvant-Induced and Collagen-Induced Arthritis: A Translational Pharmacokinetic-Pharmacodynamic Analysis.
J Pharmacol Exp Ther
; 369(3): 406-418, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30940693
4.
Evaluation of the predictive performance of physiologically based pharmacokinetic models for intramuscular injections of therapeutic proteins.
Xenobiotica
; 49(12): 1423-1433, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30794022
5.
Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats.
J Pharmacol Exp Ther
; 360(1): 226-238, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27821712
6.
Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties.
Bioorg Med Chem Lett
; 26(18): 4455-4461, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27524313
7.
Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.
Bioorg Med Chem Lett
; 26(2): 575-579, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26675441
8.
Translational pharmacokinetic/pharmacodynamic analysis in cancer pharmacology: a tool to maximize the value of antitumor efficacy from tumor bearing mice.
Drug Discov Today Technol
; 21-22: 51-56, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27978988
9.
Physiologically based pharmacokinetic models of small molecules and therapeutic antibodies: a mini-review on fundamental concepts and applications.
Biopharm Drug Dispos
; 37(2): 75-92, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26461173
10.
Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.
Bioorg Med Chem Lett
; 25(19): 4109-13, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26321361
11.
Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.
Bioorg Med Chem Lett
; 25(15): 2907-12, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048793
12.
Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.
Bioorg Med Chem Lett
; 25(6): 1333-7, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25701252
13.
Investigations into the mechanisms of pyridine ring cleavage in vismodegib.
Drug Metab Dispos
; 42(3): 343-51, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24389420
14.
Enzyme-inducing anticonvulsants increase plasma clearance of dexmedetomidine: a pharmacokinetic and pharmacodynamic study.
Anesthesiology
; 120(5): 1118-25, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24487703
15.
Identification of tertiary sulfonamides as RORc inverse agonists.
Bioorg Med Chem Lett
; 24(9): 2182-7, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24685544
16.
Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.
Bioorg Med Chem Lett
; 24(16): 3891-7, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25017032
17.
A reversed sulfonamide series of selective RORc inverse agonists.
Bioorg Med Chem Lett
; 24(24): 5769-5776, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453817
18.
Time-dependent clearance can confound exposure-response analysis of therapeutic antibodies: A comprehensive review of the current literature.
Clin Transl Sci
; 17(1): e13676, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37905360
19.
Retrospective Assessment of Translational Pharmacokinetic-Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor.
Drugs R D
; 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38700808
20.
Quantitative Assessment of Drug Efficacy and Emergence of Resistance in Patients with Metastatic Renal Cell Carcinoma Using a Longitudinal Exposure-Tumor Growth Inhibition Model: Apitolisib (Dual PI3K/mTORC1/2 Inhibitor) Versus Everolimus (mTORC1 Inhibitor).
J Clin Pharmacol
; 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38639108