Detalhe da pesquisa
1.
Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement.
Bioorg Med Chem Lett
; 21(12): 3726-9, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21570836
2.
Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
Bioorg Med Chem Lett
; 21(19): 5791-4, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21885276
3.
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Bioorg Med Chem Lett
; 21(18): 5521-7, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21813278
4.
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Bioorg Med Chem Lett
; 21(1): 315-9, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21112785
5.
Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Bioorg Med Chem Lett
; 20(21): 6231-6, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20833041
6.
N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.
Bioorg Med Chem Lett
; 19(24): 6952-6, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19879755
7.
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 19(17): 4920-3, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19660943
8.
Discordance in HER2 gene amplification in circulating and disseminated tumor cells in patients with operable breast cancer.
Cancer Med
; 2(2): 226-33, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23634290
9.
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-ß over Notch.
J Med Chem
; 56(13): 5261-74, 2013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23713656
10.
FISH-based determination of HER2 status in circulating tumor cells isolated with the microfluidic CEE™ platform.
Cancer Genet
; 204(11): 589-95, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22200084
11.
A novel platform for detection of CK+ and CK- CTCs.
Cancer Discov
; 1(7): 580-6, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22180853