Detalhe da pesquisa
1.
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment.
Drug Metab Dispos
; 49(1): 94-110, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33139460
2.
Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species.
Anal Biochem
; 556: 85-90, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29959909
3.
Single concentration loss of activity assay provides an improved assessment of drug-drug interaction risk compared to IC50-shift.
Xenobiotica
; 46(11): 953-66, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26956546
4.
Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP.
Bioorg Med Chem Lett
; 24(13): 2877-80, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24825301
5.
Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme.
Drug Metab Dispos
; 40(7): 1429-40, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22517972
6.
Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interaction.
Drug Metab Dispos
; 38(5): 841-50, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20100816
7.
An inhibitory metabolite leads to dose- and time-dependent pharmacokinetics of (R)-N-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in human subjects after multiple dosing.
Drug Metab Dispos
; 37(3): 502-13, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19088267
8.
Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.
J Med Chem
; 62(22): 10258-10271, 2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31736296
9.
Prediction of drug-drug interactions arising from mechanism-based inactivation: key input parameters and impact on risk assessment.
Curr Drug Metab
; 12(9): 871-90, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21619522