Detalhe da pesquisa
1.
Assessment of the combined vulnerability to droughts and heatwaves in Shandong Province in summer from 2000 to 2018.
Environ Monit Assess
; 196(5): 464, 2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38647697
2.
Design, synthesis, and biological evaluation of aminopyridine derivatives as novel tropomyosin receptor kinase inhibitors.
Arch Pharm (Weinheim)
; 356(3): e2200438, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36398500
3.
Therapeutic potential of targeting LSD1/ KDM1A in cancers.
Pharmacol Res
; 175: 105958, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34718134
4.
Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs.
J Enzyme Inhib Med Chem
; 37(1): 2241-2255, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35978496
5.
Design, synthesis, and evaluation of novel 3,4-isoxazolediamide derivatives for the combination treatment of azole-resistant candidiasis.
Arch Pharm (Weinheim)
; 355(12): e2200266, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36029272
6.
Design, synthesis, and biological evaluation of coumarin analogs as novel LSD1 inhibitors.
Arch Pharm (Weinheim)
; 355(2): e2100311, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-34862974
7.
Design, synthesis, and biological evaluation of 5-aminotetrahydroquinoline-based LSD1 inhibitors acting on Asp375.
Arch Pharm (Weinheim)
; 354(8): e2100102, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-33987875
8.
Discovery of 7H-pyrrolo[2,3-d]pyridine derivatives as potent FAK inhibitors: Design, synthesis, biological evaluation and molecular docking study.
Bioorg Chem
; 102: 104092, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32707280
9.
Discovery of 2,4-diaminopyrimidine derivatives targeting p21-activated kinase 4: Biological evaluation and docking studies.
Arch Pharm (Weinheim)
; 353(10): e2000097, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32627873
10.
Discovery of 2-(4-Substituted-piperidin/piperazine-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-quinazoline-2,4-diamines as PAK4 Inhibitors with Potent A549 Cell Proliferation, Migration, and Invasion Inhibition Activity.
Molecules
; 23(2)2018 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29443911
11.
Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study.
Bioorg Med Chem
; 25(13): 3500-3511, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28502459
12.
Discovery of novel 3-(1H-pyrazol-4-yl)-1H-indazole derivatives as potent type II TRK inhibitors against acquired resistance.
Eur J Med Chem
; 264: 115953, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38029466
13.
Design, synthesis and biological evaluation of pyrazolo[3,4-b]pyridine derivatives as TRK inhibitors.
RSC Med Chem
; 14(1): 85-102, 2023 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36760745
14.
Corrigendum: Untargeted metabolomics identified kynurenine as a predictive prognostic biomarker in acute myocardial infarction.
Front Immunol
; 14: 1163419, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36969229
15.
Design, synthesis and biological evaluation of novel indolin-2-one derivatives as potent second-generation TRKs inhibitors.
Eur J Med Chem
; 253: 115291, 2023 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37030091
16.
Design, synthesis, and biological evaluation of diaminopyrimidine derivatives as novel focal adhesion kinase inhibitors.
RSC Med Chem
; 14(11): 2301-2314, 2023 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37974962
17.
Discovery of CZS-241: A Potent, Selective, and Orally Available Polo-Like Kinase 4 Inhibitor for the Treatment of Chronic Myeloid Leukemia.
J Med Chem
; 66(4): 2396-2421, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36734825
18.
Discovery of the First Potent, Selective, and In Vivo Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of TRIM37-Amplified Breast Cancer.
J Med Chem
; 66(12): 8200-8221, 2023 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37279162
19.
Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents.
Eur J Med Chem
; 227: 113955, 2022 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34749201
20.
Rational drug design to explore the structure-activity relationship (SAR) of TRK inhibitors with 2,4-diaminopyrimidine scaffold.
Eur J Med Chem
; 230: 114096, 2022 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35007864