A Dual-Stimuli-Responsive Coordination Network Featuring Reversible Wide-Range Luminescence-Tuning Behavior.

We herein report a new coordination network that deforms in a smooth and reversible manner under either thermal or pressure stimulation. Concomitantly, the organic fluorophores coordinatively bound to the channel in a face-to-face arrangement respond to this structural deformation by finely adapting their conformation and arrangement. As a result, the material exhibits a remarkable dual-stimuli-responsive luminescence shift across almost the entire visible region: The emission color of the crystal gradually changes from cyan to green upon heating and then to red upon pressure compression. Furthermore, each stage exhibits a linear dependence of both the emission maximum and intensity on the stimulus and is fully reversible.

Alkylamine-Templated Niccolite Frameworks of [GaIIIMII(HCOO)6]- (M = Fe, Ni): Structure, Magnetism, and Dielectricity.

The five heterometallic formate frameworks [EtA][GaIIIFeII(HCOO)6] (1; EtA = CH3CH2NH3+), [DMA][GaIIIFeII(HCOO)6] (2; DMA = (CH3)2NH2+), [DEtA][GaIIIFeII(HCOO)6] (3; DEtA = (CH3CH2)2NH2+), [MA][GaIIINiII(HCOO)6] (4; MA = CH3NH3+), and [DMA][GaIIINiII(HCOO)6] (5) were synthesized through solvothermal methods. Complexes 1-5 are isotructural, and all crystallize in the trigonal P3̅1 c space group. Each metal center is 6-connected, with each HCOO- bridging ligand in an anti-anti mode to build a three-dimensional niccolite-like architecture. All of the complexes exhibit weak ferromagnetism at low temperature. A variable-temperature (VT) dielectric study indicates that the dielectric anomaly is induced by the freezing of motions from the protonated amines during the freezing process.

Ferroelastic Phase Transition and Switchable Dielectric Constant in Heterometallic Niccolite Formate Frameworks.

Four heterometallic formate frameworks templated by various alkylamine cations with the general formula [cat][GaIIIMnII(HCOO)6] {cat is MA (CH3NH3+) for 1, DMA [(CH3)2NH2+] for 2, EtA (CH3CH2NH3+) for 3, and DEtA [(CH3CH2)2NH2+] for 4} have been prepared and characterized by X-ray diffraction, differential scanning calorimetry, and dielectric studies. All of the complexes have niccolite-like structures, which possess the same [GaMn(HCOO)6]- anionic framework with binodal (412·63)(49·66) topology; only the counterions in the cavity are different. Complex 4 undergoes a reversible ferroelastic phase transition around 220 K accompanied by a thermally switchable dielectric constant transition triggered by the freezing of the order-disorder DEtA cations.

Unusual High-Temperature Reversible Phase-Transition Behavior, Structures, and Dielectric-Ferroelectric Properties of Two New Crown Ether Clathrates.

Molecular ferroelectrics with high-temperature reversible phase-transition behaviors are very rare and have currently become one of the hotspots in the field of ferroelectric materials. Herein we display two new crown ether clathrates possessing unusual high-temperature ferroelectric phase-transition behaviors, cyclohexyl ammonium 18-crown-6 tetrafluoroborate (or perchlorate), [Hcha-(18-crown-6)](+) [BF4](-) (1) and [Hcha-(18-crown-6)](+)[ClO4](-) (2) (Hcha = protonated cyclohexyl ammonium). We have proven their reversible structural phase transitions by variable-temperature PXRD measurements and temperature evolutions of Raman bands. Both clathrates exhibit clear ferroelectric phase transitions at about 397 and 390 K, respectively, revealed by the thermal anomalies of differential scanning calorimetry (DSC) measurements, together with abrupt dielectric anomalies in the heating and cooling processes. The measurements on ferroelectric properties using the single crystals showed optimized spontaneous polarization (Ps) of ca. 3.27 µC cm(-2) for 1 and 3.78 µC cm(-2) for 2.

Spontaneous resolution, asymmetric catalysis, and fluorescence properties of δ- and λ-[cu(tzmp)]N enantiomers from in situ [2 + 3] cycloaddition synthesis.

Although a number of acentric or chiral tetrazole complexes were synthesized from Sharpless reaction, there are no spontaneous resolution Cu(I)-tetrazole compounds from in situ [2 + 3] cycloaddition synthesis that have been reported before. The first enantiomers Δ- and Λ- of metal tetrazole compound [Cu(Tzmp)]n (1) (HTzmp = 3-tetrazolemethylpyridine) were obtained and isolated from in situ [2 + 3] cycloaddition reactions of a flexible organic nitrile (3-cyanomethylpyridine) with sodium azide in the presence of CuCl2 as the Lewis acid. Δ-1 and Λ-1 feature a homochiral helical coordination polymeric system and {4(4).6(2)} two-dimensional framework. The photoluminescence study suggests 1 exhibits strong green fluorescence in solid state with maximal emission peaks around 535 nm. Remarkably, the Δ- and Λ- of [Cu(Tzmp)]n (1) catalyzes the enantioselective Henry reaction with high yield (more than 96%) and certain enantioselectivity (up to 69%).

Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta gene as a tumour suppressor in stomach adenocarcinoma.

Background: Stomach adenocarcinoma (STAD) is the most common type of gastric cancer. In this study, the functions and potential mechanisms of hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta (HADHB) in STAD were explored. Methods: Different bioinformatics analyses were performed to confirm HADHB expression in STAD. HADHB expression in STAD tissues and cells was also evaluated using western blot, qRT-PCR, and immunohistochemistry. Further, the viability, proliferation, colony formation, cell cycle determination, migration, and wound healing capacity were assessed, and the effects of HADHB on tumour growth, cell apoptosis, and proliferation in nude mice were determined. The upstream effector of HADHB was examined using bioinformatics analysis and dual luciferase reporter assay. GSEA was also employed for pathway enrichment analysis and the expression of Hippo-YAP pathway-related proteins was detected. Results: The expression of HADHB was found to be low in STAD tissues and cells. The upregulation of HADHB distinctly repressed the viability, proliferation, colony formation, cell cycle progression, migration, invasion, and wound healing of HGC27 cells, while knockdown of HADHB led to opposite effects. HADHB upregulation impeded tumour growth and cell proliferation, and enhanced apoptosis in nude mice. KLF4, whose expression was low in STAD, was identified as an upstream regulator of HADHB. KLF4 upregulation abolished the HADHB knockdown-induced tumour promoting effects in AGS cells. Further, HADHB regulates the Hippo-YAP pathway, which was validated using a pathway rescue assay. Low expression of KLF4 led to HADHB downregulation in STAD. Conclusion: HADHB might function as a tumour suppressor gene in STAD by regulation the Hippo-YAP pathway.

Retraction Notice to: Long Noncoding RNA UCA1 Regulates PRL-3 Expression by Sponging MicroRNA-495 to Promote the Progression of Gastric Cancer.

[This retracts the article DOI: 10.1016/j.omtn.2019.10.020.].

Long Noncoding RNA UCA1 Regulates PRL-3 Expression by Sponging MicroRNA-495 to Promote the Progression of Gastric Cancer.

Gastric cancer (GC) is among the most frequently occurring malignancies worldwide. In recent years, long noncoding RNAs (lncRNAs) have been widely studied because of their ability to regulate the cellular processes involved with tumorigenesis. The present study aims to investigate the underlying molecular mechanism by which lncRNA urothelial carcinoma-associated 1 (UCA1) influences the progression of GC. Differentially expressed lncRNA UCA1 was initially identified by microarray-based analysis, after which a high expression of UCA1 was determined in GC tissues and cells. It is important to note that UCA1 could upregulate the expression of phosphatase of regenerating liver-3 (PRL-3) by sponging miR-495. The expression of UCA1 and miR-495 was altered in human GC cells to evaluate cell activity in vitro, as well as peritoneal metastasis and tumor formation ability in vivo. Results suggested that increased expression of UCA1 promoted cell proliferation, migration, and invasion, accompanied by suppressed cell apoptosis, as well as enhanced peritoneal metastasis and tumorigenesis of GC cells. Meanwhile, the upregulated expression of miR-495 could reverse the promotive effects exerted by UCA1. Taken conjointly, UCA1, as a competing endogenous RNA (ceRNA) of miR-495, could accelerate the development of GC by upregulating PRL-3, highlighting a potentially promising basis for the targeted intervention treatment of GC.

Two acentric (6, 3) topological 2-D frameworks with imidazole-containing tripodal ligand and their ferroelectric properties.

Hydrothermal reaction of three-connecting ligands 1,3,5-tris(1-imidazolyl) benzene (tib) and MnSO4 or CoSO4·7H2O provides two new metal-organic frameworks, {[Mn(tib)2(H2O)4]SO4}n (1) and {[Co(tib)2(H2O)4]SO4}n (2). Single-crystal X-ray diffraction studies reveal that complexes 1 and 2 belong to the polar point group 3m, and have the same two-dimensional honeycomb networks with (6, 3) topology. The ferroelectric behavior investigation indicates that both compounds are typical ferroelectrics with an electric hysteresis loop showing a remnant polarization (P(r)) of ca. 0.586 µC cm(-2) and a coercive field (E(c)) of 2000 V cm(-1) for 1 and P(r) of ca. 0.208 µC cm(-2) and a coercive field (E(c)) of 2600 V cm(-1) for 2.