Detalhe da pesquisa
1.
Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19.
N Engl J Med
; 390(3): 230-241, 2024 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38231624
2.
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors.
Nature
; 582(7811): 289-293, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32272481
3.
Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19.
Proc Natl Acad Sci U S A
; 120(18): e2301775120, 2023 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37094153
4.
Pigment Diversity in Leaves of Caladium × hortulanum Birdsey and Transcriptomic and Metabolic Comparisons between Red and White Leaves.
Int J Mol Sci
; 25(1)2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38203776
5.
Diversity, classification, and EST-SSR-based association analysis of caladium ornamental traits.
Physiol Plant
; 175(1): e13841, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36513960
6.
Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety.
Bioorg Med Chem
; 87: 117316, 2023 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37187077
7.
Discovery of novel cGAS inhibitors based on natural flavonoids.
Bioorg Chem
; 140: 106802, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37666112
8.
Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease.
Int J Mol Sci
; 24(10)2023 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37239980
9.
Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease.
Bioorg Chem
; 128: 106109, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36049322
10.
A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors.
Acta Pharmacol Sin
; 43(2): 483-493, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33907306
11.
Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease.
Angew Chem Int Ed Engl
; 61(52): e202212378, 2022 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36308706
12.
Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis.
Angew Chem Int Ed Engl
; 61(5): e202114922, 2022 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34851543
13.
What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design.
Med Res Rev
; 41(4): 1965-1998, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33460213
14.
Molecular evolution of chloroplast genomes in subfamily Zingiberoideae (Zingiberaceae).
BMC Plant Biol
; 21(1): 558, 2021 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34814832
15.
Structural basis for ligand recognition of the human thromboxane A2 receptor.
Nat Chem Biol
; 15(1): 27-33, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30510189
16.
Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation.
Bioorg Chem
; 110: 104767, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33667900
17.
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor.
Acta Pharmacol Sin
; 42(3): 482-490, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-32581257
18.
In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing.
J Chem Inf Model
; 60(6): 3265-3276, 2020 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32459092
19.
Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity.
J Nat Prod
; 83(4): 1229-1237, 2020 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32100544
20.
Anti-inflammatory signaling through G protein-coupled receptors.
Acta Pharmacol Sin
; 41(12): 1531-1538, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33060777