RESUMO
Highly enantioselective synthesis of α,ß-epoxy esters was achieved via one-pot organocatalytic epoxidation and consequent oxidative esterification. Excellent enantioselectivities (up to 99% ee) and good yields were obtained for a variety of α,ß-epoxy esters. The method was readily scaled. Furthermore the product was applied towards the synthesis of (-)-clausenamide with excellent enantioselectivities (>99% ee).
Assuntos
Azóis/química , Compostos de Epóxi/síntese química , Ésteres/síntese química , Catálise , Compostos de Epóxi/química , Ésteres/química , Lactamas/síntese química , Lactamas/química , Lignanas/síntese química , Lignanas/química , Estrutura Molecular , Oxirredução , EstereoisomerismoRESUMO
An organocatalytic cascade reaction of 2-nitrocyclohexanone and α,ß-unsaturated aldehydes was developed. Bicyclo[3.3.1]nonanone products were obtained with good yields and excellent enantioselectivities. The reaction occurred with unusual regioselectivity. A dienolate-iminium activation mechanism was proposed. The products were transformed to eight-membered cyclic ketones with high enantioselectivity.
Assuntos
Aldeídos/química , Cicloexanonas/química , Compostos Bicíclicos com Pontes/química , Catálise , Iminas/química , Cetonas/química , EstereoisomerismoRESUMO
Highly enantioselective synthesis of nitrocyclopropanes was achieved via the organocatalytic conjugate addition of dimethyl bromomalonate to nitroalkenes and the consequent intramolecular cyclopropanation. 6'-Demethyl quinine was found to be the efficient catalyst. Excellent enantioselectivities, diastereoselectivities, and good yields were obtained for a variety of aryl or heteroaryl nitroethylenes.