Detalhe da pesquisa
1.
Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.
Angew Chem Int Ed Engl
; 61(5): e202112295, 2022 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34762767
2.
Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases.
J Am Chem Soc
; 139(36): 12696-12703, 2017 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28820255
3.
Hydrogeochemical and isotopic assessment for characterizing groundwater quality in the Mitidja plain (northern Algeria).
Environ Sci Pollut Res Int
; 30(33): 80029-80054, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37291345
4.
Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library.
Angew Chem Int Ed Engl
; 51(42): 10664-9, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22996590
5.
N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-ß-Lactamases.
J Med Chem
; 65(5): 3913-3922, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35188771
6.
Chelation-mediated palladium(II)-catalyzed domino Heck-Mizoroki/Suzuki-Miyaura reactions using arylboronic acids: increasing scope and mechanistic understanding.
J Org Chem
; 76(8): 2433-8, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21417443
7.
N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-ß-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa.
RSC Med Chem
; 12(10): 1698-1708, 2021 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34778771
8.
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms.
Adv Sci (Weinh)
; 8(12): e2004369, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34165899
9.
Multitarget Therapeutic Strategies for Alzheimer's Disease: Review on Emerging Target Combinations.
Biomed Res Int
; 2020: 5120230, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32714977
10.
N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases.
J Med Chem
; 63(15): 8359-8368, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32470298
11.
Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics.
Eur J Med Chem
; 188: 112005, 2020 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31911294
12.
A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer's Disease.
Front Aging Neurosci
; 11: 148, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31316368
13.
High affinity rigidified AT2 receptor ligands with indane scaffolds.
Medchemcomm
; 10(12): 2146-2160, 2019 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32904210
14.
Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens.
Eur J Med Chem
; 165: 133-141, 2019 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30665143
15.
New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation.
Bioorg Med Chem
; 16(3): 1474-80, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18042388
16.
Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa.
ACS Infect Dis
; 4(6): 988-997, 2018 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29485268
17.
Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor.
ACS Chem Biol
; 13(9): 2449-2455, 2018 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30088919
18.
Disruption of Fibers from the Tau Model AcPHF6 by Naturally Occurring Aurones and Synthetic Analogues.
ACS Chem Neurosci
; 7(7): 995-1003, 2016 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27225823
19.
Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease.
Eur J Med Chem
; 121: 283-293, 2016 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27266998
20.
Multitarget Therapeutics for Neurodegenerative Diseases.
Biomed Res Int
; 2020: 6532827, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32695817