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Immunity ; 32(5): 681-91, 2010 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-20493731

RESUMO

Dectin-2 (gene symbol Clec4n) is a C-type lectin expressed by dendritic cells (DCs) and macrophages. However, its functional roles and signaling mechanisms remain to be elucidated. Here, we generated Clec4n(-/-) mice and showed that this molecule is important for host defense against Candida albicans (C. albicans). Clec4n(-/-) DCs had virtually no fungal alpha-mannan-induced cytokine production. Dectin-2 signaling induced cytokines through an FcRgamma chain and Syk-CARD9-NF-kappaB-dependent signaling pathway without involvement of MAP kinases. The yeast form of C. albicans induced interleukin-1beta (IL-1beta) and IL-23 secretion in a Dectin-2-dependent manner. In contrast, cytokine production induced by the hyphal form was only partially dependent on this lectin. Both yeast and hyphae induced Th17 cell differentiation, in which Dectin-2, but not Dectin-1, was mainly involved. Because IL-17A-deficient mice were highly susceptible to systemic candida infection, this study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation.


Assuntos
Candida albicans/imunologia , Candidíase/imunologia , Diferenciação Celular , Interleucina-17/metabolismo , Lectinas Tipo C/imunologia , Mananas/imunologia , Linfócitos T Auxiliares-Indutores , Animais , Células Cultivadas , Imunoensaio , Interleucina-1beta/imunologia , Interleucina-23/imunologia , Lectinas Tipo C/genética , Masculino , Camundongos , Camundongos Knockout , Transdução de Sinais , Linfócitos T Auxiliares-Indutores/citologia , Linfócitos T Auxiliares-Indutores/imunologia
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