Detalhe da pesquisa
1.
Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5trioxazatriquinane skeleton.
Bioorg Med Chem Lett
; 82: 129151, 2023 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36690040
2.
Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors.
Bioorg Med Chem Lett
; 59: 128527, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35007722
3.
Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton.
Bioorg Med Chem Lett
; 59: 128530, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35007725
4.
Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives.
Bioorg Med Chem Lett
; 59: 128550, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041942
5.
Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands.
Bioorg Med Chem Lett
; 56: 128485, 2022 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34861349
6.
Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring.
Bioorg Med Chem Lett
; 60: 128555, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35051577
7.
Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine.
Bioorg Med Chem Lett
; 30(17): 127360, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32738987
8.
Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.
Bioorg Med Chem Lett
; 30(3): 126893, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31879208
9.
Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities.
Molecules
; 25(5)2020 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32131542
10.
Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.
Bioorg Med Chem Lett
; 29(18): 2655-2658, 2019 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31375290
11.
Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.
Bioorg Med Chem
; 27(8): 1747-1758, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30871861
12.
Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.
Bioorg Med Chem Lett
; 28(4): 774-777, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29338909
13.
Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.
Bioorg Med Chem Lett
; 27(17): 4176-4179, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28739044
14.
Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives.
Bioorg Med Chem
; 25(16): 4375-4383, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28662966
15.
ZnCl2-Promoted Intramolecular Hetero-Diels-Alder Reaction of o-Alkynylphenylcarbodiimides for Synthesis of Dihydrodibenzo[b,g][1,8]naphthyridines.
Chem Pharm Bull (Tokyo)
; 64(9): 1364-9, 2016 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27321228
16.
Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound.
Bioorg Med Chem Lett
; 25(21): 4890-4892, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26099536
17.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.
Bioorg Med Chem
; 23(19): 6271-9, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26346669
18.
Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism.
Bioorg Med Chem Lett
; 24(13): 2851-4, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24835200
19.
The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives.
Bioorg Med Chem Lett
; 23(1): 268-72, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200250
20.
Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton.
Org Lett
; 25(19): 3407-3411, 2023 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37154730