Detalhe da pesquisa
1.
The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins.
Mol Cell
; 42(5): 662-72, 2011 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21658606
2.
Conserved regulatory elements in AMPK.
Nature
; 498(7453): E8-10, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23765502
3.
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Drug Metab Dispos
; 41(1): 60-71, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23033255
4.
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Proc Natl Acad Sci U S A
; 105(26): 9059-64, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18579783
5.
Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV.
J Med Chem
; 63(17): 9623-9649, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787097
6.
In silico discovery of transcription regulatory elements in Plasmodium falciparum.
BMC Genomics
; 9: 70, 2008 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18257930
7.
Structure-based assessment of disease-related mutations in human voltage-gated sodium channels.
Protein Cell
; 8(6): 401-438, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28150151
8.
Past, Current, and Future Developments of Therapeutic Agents for Treatment of Chronic Hepatitis B Virus Infection.
J Med Chem
; 60(15): 6461-6479, 2017 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28383274
9.
Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.
J Med Chem
; 60(8): 3352-3371, 2017 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28339215
10.
Profiling the kinome for drug discovery.
Drug Discov Today Technol
; 3(3): 269-76, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-24980528
11.
PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.
Science
; 349(6244): 187-91, 2015 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26160948
12.
Conformational searches elucidate effects of stereochemistry on structures of deoxyadenosine covalently bound to tumorigenic metabolites of benzo[C] phenanthrene.
Front Biosci
; 9: 2807-18, 2004 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15353316
13.
Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.
ACS Med Chem Lett
; 5(9): 993-8, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25221655
14.
Correction to Past, Current, and Future Developments of Therapeutic Agents for Treatment of Chronic Hepatitis B Virus Infection.
J Med Chem
; 60(15): 6766-6767, 2017 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28613860
15.
AMP-activated protein kinase undergoes nucleotide-dependent conformational changes.
Nat Struct Mol Biol
; 19(7): 716-8, 2012 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22659875
16.
Large-scale annotation of small-molecule libraries using public databases.
J Chem Inf Model
; 47(4): 1386-94, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17608408
17.
Study of gene function based on spatial co-expression in a high-resolution mouse brain atlas.
BMC Syst Biol
; 1: 19, 2007 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17437647
18.
A probability-based approach for the analysis of large-scale RNAi screens.
Nat Methods
; 4(10): 847-9, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17828270
19.
Learning from the data: mining of large high-throughput screening databases.
J Chem Inf Model
; 46(6): 2381-95, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125181
20.
An efficient rapid system for profiling the cellular activities of molecular libraries.
Proc Natl Acad Sci U S A
; 103(9): 3153-8, 2006 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16492761