Detalhe da pesquisa
1.
The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 21(16): 4909-12, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21742496
2.
Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.
J Med Chem
; 59(10): 4711-23, 2016 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27187609
3.
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Science
; 351(6278): 1208-13, 2016 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26912361
4.
Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line.
Oncogene
; 22(40): 6204-13, 2003 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-13679859
5.
Gene expression profiling of epothilone A-resistant cells.
Novartis Found Symp
; 243: 119-32; discussion 132-6, 180-5, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-11990772
6.
Transcription regulation by histone deacetylases.
Novartis Found Symp
; 259: 238-45; discussion 245-8, 285-8, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15171258
7.
Inhibiting Tankyrases sensitizes KRAS-mutant cancer cells to MEK inhibitors via FGFR2 feedback signaling.
Cancer Res
; 74(12): 3294-305, 2014 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24747911
8.
Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
J Med Chem
; 54(13): 4752-72, 2011 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21650221
9.
Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).
J Med Chem
; 53(7): 2952-63, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20205394
10.
Activation of mitochondrial pathway is crucial for tumor selective induction of apoptosis by LAQ824.
Cell Cycle
; 5(15): 1662-8, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16861932
11.
Rapid expression cloning of receptors using epitope-tagged ligands and high-speed cell sorting.
Cytometry A
; 51(2): 59-67, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12541280