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1.
Opt Express ; 28(21): 30362-30378, 2020 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-33115040

RESUMO

Ring artifacts seriously deteriorate the quality of CT images. Intensity-dependence of detector responses will result in intensity-dependent ring artifacts and time-dependence of CT hardware systems will result in time-dependent ring artifacts. However, only the intensity-dependent ring artifacts are taken into consideration in most post-processing methods. Therefore, the purpose of this study is to propose a general post-processing method, which has a significant removal effect on the intensity-dependent ring artifacts and the time-dependent ring artifacts. First in the proposed method, transform raw CT images into polar coordinate images, and the ring artifacts will manifest as stripe artifacts. Secondly, obtain structure images by smoothing the polar coordinate images and acquire texture images containing some details and stripe artifacts by subtracting the structure images from the polar coordinate images. Third, extract the stripe artifacts from the texture images using mean extraction and texture classification, and obtain the extracted ring artifacts by transforming the extracted stripe artifacts from polar coordinates into Cartesian coordinates. Finally, obtain corrected CT images by subtracting the extracted ring artifacts from the raw CT images, and iterate the corrected CT images in above steps until the ring artifacts extracted in the last iteration are weak enough. Simulation and real data show that the proposed method can remove the intensity-dependent ring artifacts and the time-dependent ring artifacts effectively while preserving image details and spatial resolution. In particular, real data prove that the method is suitable for new CT systems such as the photon counting CT.

2.
J Infect Dis ; 219(5): 750-759, 2019 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-30260401

RESUMO

BACKGROUND: Strategies that target functional recovery of exhausted hepatitis B virus (HBV)-specific CD8+ T cells are beneficial for viral control, but the potential for interleukin 21 (IL-21) to rescue CD8+ T-cell function is not well understood. METHODS: We investigated the effect of IL-21 on CD8+ T-cell responses by phenotypic and functional analysis of samples from patients with chronic HBV infection and a mouse model with HBV expression. RESULTS: IL-21 promoted the proliferative capacity of HBV-specific CD8+ T cells and down-regulated expression of the inhibitory receptors programmed death 1 and T-cell immunoglobulin domain and mucin domain 3. Additionally, IL-21 boosted the production of interferon-γ, granzyme B, and CD107a in HBV-specific CD8+ T cells and enhanced the cytolytic activity of CD8+ T cells against HepG2.2.15 cells. Notably, an HBV mouse model established from IL-21 receptor knockout mice showed significantly decreased frequency of HBV-specific CD8+ T cells and increased levels of serum hepatitis B surface antigen (HBsAg). Meanwhile, administration of recombinant mouse IL-21 in an HBV mouse model established from wild-type mice resulted in enhanced functionality of HBV-specific CD8+ T cells and accelerated HBsAg clearance. CONCLUSIONS: IL-21 enhances the antiviral effect of HBV-specific CD8+ T cells, suggesting that it may contribute to viral clearance in chronic HBV infection.


Assuntos
Linfócitos T CD8-Positivos/imunologia , Vírus da Hepatite B/imunologia , Hepatite B Crônica/imunologia , Interleucinas/metabolismo , Animais , Proliferação de Células , Testes Imunológicos de Citotoxicidade , Modelos Animais de Doenças , Regulação para Baixo , Antígenos de Superfície da Hepatite B/sangue , Humanos , Fatores Imunológicos/metabolismo , Interleucinas/deficiência , Masculino , Camundongos Endogâmicos C57BL , Camundongos Knockout
3.
J Xray Sci Technol ; 27(5): 965-979, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31356226

RESUMO

Based on the structural tensor of projection, this study aims to address and test a new improved algorithm applying to the distort projection data to generate a high qualified image by reducing the artifacts and noise from scattering in the cone-beam computed tomography (CBCT). Since the scattering information has a large relationship with the structure of the object, which is reflected by the projection, regional model knowledge for scattering is accomplished by finding the relationship between projection and scattering. As the tensor, the gradient of projection is first calculated in the process for estimating the direction and structural edge of the object. Then, the Determinant and Traces of the tensor map with different characteristics are computed to determine the different regions. By modeling and fitting the regions of scattering distribution, the knowledge of scattering parameters corresponding to a different region is obtained. Based on the similarity of scattering distribution in adjacent angles, the scatterings with angle sequence are completed by interpolating the prior knowledge obtained through the sparse sampling. By performing the studies on polychromatic X-ray to test the performance of the scattering estimation algorithm, the results show a significant improvement in the images that are reconstructed from the corrected projection. The root mean square error (RMSE) of the proposed method is reduced by 21.8% and 39.8%, respectively. Peak signal to noise ratio (PSNR), and universal quality index (UQI) also indicate better uniformity, where the PSNR is increased by 7.4% and 56.7%, UQI is increased by 70.8% and 262.3% for experimental #Wheel and #Cylinder, respectively.


Assuntos
Tomografia Computadorizada de Feixe Cônico/métodos , Aumento da Imagem/métodos , Espalhamento de Radiação , Algoritmos , Artefatos , Imagens de Fantasmas , Processamento de Sinais Assistido por Computador , Razão Sinal-Ruído , Raios X
4.
J Xray Sci Technol ; 26(2): 227-240, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29036876

RESUMO

This study aims to investigate and test a new image reconstruction algorithm applying to the low-signal projections to generate high quality images by reducing the artifacts and noise in the cone-beam computed tomography (CBCT). For the low-signal and noisy projections, a multiple sampling method is first utilized in projection domain to suppress environmental noise, which guarantees the accuracy of the data for reconstruction, simultaneously. Next, a fuzzy entropy based method with block matching 3D (BM3D) filtering algorithm is employed to improve the image quality to reduce artifacts and noise in image domain. Then, simulation studies on polychromatic spectrum were performed to evaluate the performance of the proposed new algorithm. Study results demonstrated significant improvement in the signal-to-noise ratios (SNRs) and contrast-to-noise ratios (CNRs) of the images reconstructed using the new algorithm. SNRs and CNRs of the new images were averagely 40% and 20% higher than those of the previous images reconstructed using the traditional algorithms, respectively. As a result, since the new image reconstruction algorithm effectively reduced the artifacts and noise, and produced images with better contour and grayscale distribution, it has the potential to improve image quality using the original CBCT data with the low and missing signals.


Assuntos
Algoritmos , Artefatos , Tomografia Computadorizada de Feixe Cônico/métodos , Imageamento Tridimensional/métodos , Lógica Fuzzy , Imagens de Fantasmas
5.
BMC Infect Dis ; 16(1): 734, 2016 12 05.
Artigo em Inglês | MEDLINE | ID: mdl-27919225

RESUMO

BACKGROUND: H7N9 human cases were first detected in mainland China in March 2013. Circulation of this virus has continued each year shifting to typical winter months. We compared the clinical and epidemiologic characteristics for the first three waves of virus circulation. METHODS: The first wave was defined as reported cases with onset dates between March 31-September 30, 2013, the second wave was defined as October 1, 2013-September 30, 2014 and the third wave was defined as October 1, 2014-September 30, 2015. We used simple descriptive statistics to compare characteristics of the three distinct waves of virus circulation. RESULTS: In mainland China, 134 cases, 306 cases and 219 cases were detected and reported in first three waves, respectively. The median age of cases was statistically significantly older in the first wave (61 years vs. 56 years, 56 years, p < 0.001) compared to the following two waves. Most reported cases were among men in all three waves. There was no statistically significant difference between case fatality proportions (33, 42 and 45%, respectively, p = 0.08). There were no significant statistical differences for time from illness onset to first seeking healthcare, hospitalization, lab confirmation, initiation antiviral treatment and death between the three waves. A similar percentage of cases in all waves reported exposure to poultry or live poultry markets (87%, 88%, 90%, respectively). There was no statistically significant difference in the occurrence of severe disease between the each of the first three waves of virus circulation. Twenty-one clusters were reported during these three waves (4, 11 and 6 clusters, respectively), of which, 14 were considered to be possible human-to-human transmission. CONCLUSION: Though our case investigation for the first three waves found few differences between the epidemiologic and clinical characteristics, there is continued international concern about the pandemic potential of this virus. Since the virus continues to circulate, causes more severe disease, has the ability to mutate and become transmissible from human-to-human, and there is limited natural protection from infection in communities, it is critical that surveillance systems in China and elsewhere are alert to the influenza H7N9 virus.


Assuntos
Subtipo H7N9 do Vírus da Influenza A/isolamento & purificação , Influenza Humana/virologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , China/epidemiologia , Feminino , Hospitalização/estatística & dados numéricos , Humanos , Subtipo H7N9 do Vírus da Influenza A/classificação , Subtipo H7N9 do Vírus da Influenza A/genética , Influenza Humana/epidemiologia , Masculino , Pessoa de Meia-Idade , Pandemias , Estações do Ano , Adulto Jovem
6.
Environ Sci Pollut Res Int ; 31(16): 23995-24013, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38436854

RESUMO

In this work, the characteristics of the exothermic reaction between ammonium nitrate and sulfide ores were explored using COMSOL Multiphysics. This reaction can cause an increase in temperature within the blast holes of sulfide mines and can potentially induce premature explosions of the explosives. Initially, simulations were conducted to observe temperature variations in blast holes before and after the loading of explosives. Then, the impact of blast hole diameter and initial temperature on the thermal environment was assessed. Subsequent analysis focused on the fluid field's dynamics, examining flow rate changes and the concentration of signature gases produced by the reaction. Additionally, the influence of blast hole diameter on these parameters was evaluated. The results show that the blast hole temperature is positively related to its diameter and initial temperature. When the diameter of the blast hole is 120 mm and 165 mm, a significant change in flow rate is observed, with a trend of being rapidly increased and then rapidly decreased. The production of NH3 is always found to be greater than that of the other two gases. As for NO and SO2, their production is characterized by an approximate ratio of 1:2. The numerical simulation results can provide important theoretical guidance for the spontaneous detonation of blast hole in sulfide mines.


Assuntos
Substâncias Explosivas , Nitratos , Simulação por Computador , Explosões , Sulfetos , Gases
7.
Cell Discov ; 10(1): 22, 2024 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-38409116

RESUMO

Human cerebellum encompasses numerous neurons, exhibiting a distinct developmental paradigm from cerebrum. Here we conducted scRNA-seq, scATAC-seq and spatial transcriptomic analyses of fetal samples from gestational week (GW) 13 to 18 to explore the emergence of cellular diversity and developmental programs in the developing human cerebellum. We identified transitory granule cell progenitors that are conserved across species. Special patterns in both granule cells and Purkinje cells were dissected multidimensionally. Species-specific gene expression patterns of cerebellar lobes were characterized and we found that PARM1 exhibited inconsistent distribution in human and mouse granule cells. A novel cluster of potential neuroepithelium at the rhombic lip was identified. We also resolved various subtypes of Purkinje cells and unipolar brush cells and revealed gene regulatory networks controlling their diversification. Therefore, our study offers a valuable multi-omics landscape of human fetal cerebellum and advances our understanding of development and spatial organization of human cerebellum.

8.
Materials (Basel) ; 16(17)2023 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-37687491

RESUMO

Corrosion product films (CPFs) have significant effects on hydrogen permeation and the corrosion process at the crack tip. This paper established a two-dimensional calculation model to simulate the formation of CPFs at the crack tip and its effects on the crack tip stress status and hydrogen diffusion. The CPFs were simplified as a single-layer structure composed of Fe2O3, the effective CPFs boundary was modeled by the diffusion of oxygen, and the CPF-induced stress was modeled by hygroscopic expansion. The simulation was conducted with two stages; the first stage was to simulate the formation of CPFs formation and its effects on the crack tip stress status, while the second stage focused on the hydrogen diffusion with and without CPF formation under different external tensile loads. The results indicate that the highest compressive stress induced by the formation of CPFs is located at 50~60° of the crack contour and dramatically weakens the crack tip tensile stress at low-stress status. The CPFs can inhibit the hydrogen permeation into the crack tip, and the hydrostatic pressure effects on the redistribution of the permeated hydrogen are significant under larger external load conditions.

9.
Environ Sci Pollut Res Int ; 30(7): 17076-17093, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36630032

RESUMO

As the shallow mineral resources are nearly depleted, the mining of deep resources has become an urgent problem to be studied. The increase in mine depth can lead to the increase of mine heat hazard, which is a critical concern for mining safety/occupational health and safety. However, there are limited review articles available regarding the prevention of mine heat hazard. To fill in this gap, a bibliometric analysis and knowledge mapping of the field of mine heat hazard prevention are presented in this paper. A total of 314 papers from the Web of Science (WOS) core collection database that published between January 1998 and July 2022 were analyzed using VOSviewer and CiteSpace. China, South Africa, Poland, USA, and Australia are the top five countries in this field. The important journals are Applied Thermal Engineering, Applied Energy, Energies, and International Journal of Mining Science and Technology. In addition, the research focal points and two research fronts were identified and discussed. The knowledge base of mine heat hazard research focuses on mine cooling technology, energy efficiency optimization of cooling systems, thermodynamic theory, and occupational health. There are two research fronts. One is to use the numerical simulation method to study various problems such as simulate the performance of refrigeration systems and thermal comfort in mines. The second is to study the occupational health impact of climate change on miners. Therefore, this paper provides readers and academics with an overview of the intellectual structure and knowledge body that have been developed on the subject of mine heat hazard.


Assuntos
Bibliometria , Temperatura Alta , Mineração , Polônia , Tecnologia
10.
Environ Sci Pollut Res Int ; 30(53): 113151-113174, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37853221

RESUMO

Direct application of high-sulfur fuels and ores can cause environmental pollution (such as air pollution and acid rain) and, in serious cases, endanger human health and contribute to property damage. In the background of preserving the environment, microbial desulfurization technologies for high-sulfur fuels and ores are rapidly developed. This paper aims to reveal the progress of microbial desulfurization research on fuels and ores using bibliometric analysis. 910 publications on microbial desulfurization of fuels and ores from web core databases were collected in this work, spanning 39 years. Through 910 retrieved documents, collaborative networks of authors, institutions and countries were mapped by this work, the sources of highly cited articles and cited documents were statistically analyzed, and keyword development from different perspectives was discussed. The results of the study provide a reference for microbial desulfurization research and benefit environmental protection and energy green applications.


Assuntos
Poluição do Ar , Enxofre , Humanos , Indústrias
11.
J Colloid Interface Sci ; 640: 179-191, 2023 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-36848771

RESUMO

Integrating high flame retardancy and excellent electromagnetic interference (EMI) shielding into polymetric materials is extremely necessary, and well dispersing conductive fillers into polymeric materials is still a great challenge because of incompatible interfacial polarity between polymer matrix and conductive fillers. Therefore, under the premise of maintaining integral conductive films in the process of hot compression, constructing a novel EMI shielding polymer nanocomposites where conductive films closely adhere to polymer nanocmposites layers should be a fascinating stratety. In this work, salicylaldehyde-modified chitosan decorated titanium carbide nanohybrid (Ti3C2Tx-SCS) was combined with piperazine-modified ammonium polyphosphate (PA-APP) to fabricate thermoplastic polyurethane (TPU) nanocomposites, which were used for construction of hierarchical nanocomposite films by inserting reduced graphene oxide (rGO) films into TPU/PA-APP/Ti3C2Tx-SCS nanocomposite layers through our self-developed air assisted hot pressing technique. The total heat release, total smoke release and total carbon monoxide yield for TPU nanocomposite containing 4.0 wt% Ti3C2Tx-SCS nanohybrid were 58.0%, 58.4% and 75.8% lower than those of pristine TPU, respectively. Besides, the hierarchical TPU nanocomposite film containing 1.0 wt% Ti3C2Tx-SCS presented an averaged EMI shielding effectiveness of 21.3 dB in X band. This work provides a promising strategy for fabricating fire safe and EMI shielding polymer nanocomposites.

12.
Plants (Basel) ; 12(6)2023 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-36987095

RESUMO

Manganese deficiency critically impairs the function and stability of photosystem II (PSII) and negatively impacts crop growth and yield. However, the response mechanisms of carbon and nitrogen metabolism to Mn deficiency in different genotypes of maize and the differences in Mn deficiency tolerance are unclear. Herein, three different genotypes of maize seedlings (sensitive genotype: Mo17, tolerant genotype: B73, and B73 × Mo17) were exposed to Mn deficiency treatment for 16 days using liquid culture with different concentrations of MnSO4 [0.00, 2.23, 11.65, and 22.30 mg/L (control)]. We found that complete Mn deficiency significantly reduced maize seedling biomass; negatively affected the photosynthetic and chlorophyll fluorescence parameters; and depressed nitrate reductase, glutamine synthetase, and glutamate synthase activity. This resulted in reduced leaf and root nitrogen uptake, with Mo17 being most severely inhibited. B73 and B73 × Mo17 maintained higher sucrose phosphate synthase and sucrose synthase activities and lower neutral convertase activity compared to Mo17, which resulted in higher accumulation of soluble sugars and sucrose and maintenance of the osmoregulation capacity of leaves, which helped mitigate damage caused by Mn deficiency. The findings revealed the physiological regulation mechanism of carbon and nitrogen metabolism in different genotypes of maize seedlings that resist Mn deficiency stress, providing a theoretical basis for developing high yield and quality.

13.
Materials (Basel) ; 15(3)2022 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-35160826

RESUMO

Stress corrosion cracking (SCC) is an important destruction form of materials such as stainless steel, nickel-based alloy and their welded components in nuclear reactor pressure vessels and pipes. The existing popular quantitative prediction models of SCC crack growth rate are mainly influenced by fracture toughness values KJc or Jc. In particular, the composite constraint, containing the in-plane constraints and out-of-plane constraints around the crack front, has a significant influence on the fracture toughness of structures in nuclear power plants. Since the plastic strain gradient is a characterization parameter of the quantitative prediction model for crack growth rate, it may be a characterization parameter of composite constraint. On the basis of the experimental data at a low temperature of alloy steel 22NiMoCr3-7 used in nuclear pressure vessels, the gradient of equivalent plastic strain DPEEQ around the crack fronts at different constraint levels was calculated using the finite element method, which introduces a new non-dimensional constraint parameter Dp, to uniformly characterize the in-plane and out-of-plane constraint effects. Compared with constraint parameters APEEQ or Ap, the process of obtaining parameters DPEEQ or Dp is much simpler and easier. In a wide range, a single correlation curve was drawn between parameter Dp and normalized fracture toughness values KJc/Kref or Jc/Jref of specimens at a low or high constraint level. Therefore, regardless of whether the constraint levels of the structures or standard specimens are low or high, constraint parameter Dp can be used to measure their fracture toughness. To build an evaluation method that has structural integrity and safety while containing the composite constraint effects, in addition to accurate theoretical interpretation, further verification experiments, numerical simulations and detailed discussions are still needed.

14.
Comput Intell Neurosci ; 2022: 9123922, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36268161

RESUMO

The work reported here primarily aims to realize the automatic generation of couplets using the linguistic topology of deep neural network (DNN). First, the symmetry, topology, and cognitive linguistics of language are explored to lay a theoretical foundation for subsequent model establishment and analysis. Then, the recurrent neural network (RNN) is employed to build the Seq2Seq model, and Liweng's Guide to Rhyme (an ancient Chinese enlightenment reading material to poetry creation) is imported into the Seq2Seq model as a basic corpus. Eventually, the entire system is implemented automatically on TensorFlow. The system undergoes tests of the five-character quatrain, the seven-character quatrain, the couplet, and the part-of-speech detection. Results demonstrate that both the first and the second lines of the couplet present an excellent correspondence regarding sentences and words. After some famous verses are entered, the second line of the couplet obtained is quite vivid and appropriate. Meanwhile, the results can be generated quickly and meet the requirements on rhyme and couplet matching. This model can input verses according to users' own needs and generate the second line of the couplet quickly, showing good correspondence in words, part-of-speech, and sentence pattern. Because the couplet belongs to Chinese traditional culture, it has a strong local Chinese cultural flavor. The system designed based on computer technology can help people learn and experience the charm of couplets.


Assuntos
Idioma , Linguística , Humanos , Linguística/métodos , Redes Neurais de Computação , Leitura , Cognição
15.
Artigo em Inglês | MEDLINE | ID: mdl-36078412

RESUMO

Emergency management research is used to deal with the increasing number of extreme weather threats in urban areas. This paper uses causal analysis based on systems theory (CAST) to review the subway water ingress accident and the government's emergency management actions in Zhengzhou, Henan Province, during the heavy rainstorm disaster on 20 July 2021. The aims of this article are to establish safety control structures at both the enterprise level and the government level, and to systematically analyze the problems in emergency management in Zhengzhou City. Our analysis found that the construction of disaster prevention facilities restricted emergency management. Therefore, we suggest that enterprises and governments not only pay attention to emergency management, but also to the construction of disaster prevention facilities. This article also points out that the system of chief executive responsibility that is implemented in China is becoming a double-edged sword in emergency management. Our study makes recommendations for enhancing the capacities of emergency management, points out the shortcomings of the existing emergency management structure, and provides knowledge gained for future emergency management research.


Assuntos
Desastres , Ferrovias , Acidentes , China , Cidades
16.
Artigo em Inglês | MEDLINE | ID: mdl-35742316

RESUMO

To objectively grasp the current situation and development trend of resilient cities or communities (RC) research. The articles in Web of Science (WOS) Core Collection databases from 1995 to 2022 were used as a sample, and bibliometrics was used to statistically analyze the year of publication and number of articles, highly cited documents and keyword hotness in this field. VOSviewer was used to explore the knowledge graph of RC research documents. The results show that: the development process is roughly divided into 3 periods: no attention (1995-2004), starting (2005-2014), and rapid growth (2015-2021). The journal "Sustainability" and "International journal of disaster risk reduction" are the key journals publishing RC research. Serre and Shaw are the most productive authors. The USA is still the leading country in this field of RC. Colorado State Univ, Texas a&m Univ, and Delft Univ Technol are the main research institutions. The keyword analysis indicates the hot topics in different periods. Moreover, several limitations and some recommendations for future research on RC are also given based on this.


Assuntos
Bibliometria , Gerenciamento de Dados , Cidades , Colorado , Bases de Dados Factuais , Publicações
17.
Materials (Basel) ; 15(2)2022 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-35057197

RESUMO

Hydrogen embrittlement, as one of the major concerns for austenitic stainless steel, is closely linked to the diffusion of hydrogen through the grain boundary of materials. The phenomenon is still not well understood yet, especially the full interaction between hydrogen diffusion and the misorientation of the grains. This work aimed at the development of a robust numerical strategy to model the full coupling of the hydrogen diffusion and the anisotropic behavior of crystals in 316 stainless steel. A constitutive model, which allows easy incorporation of crystal orientation, various loading conditions, and arbitrary model geometries, was established by using the finite element package ABAQUS. The study focuses on three different bicrystal models composed of misoriented crystals, and the results indicate that the redistribution of hydrogen is significant closely to the grain boundary, and the redistribution is driven by the hydrostatic pressure caused by the misorientation of two neighboring grains. A higher elastic modulus ratio along the tensile direction will lead to a higher hydrogen concentration difference in the two grains equidistant from the grain boundary. The hydrogen concentration shows a high value in the crystal along the direction with stiff elastic modulus. Moreover, there exists a large hydrogen concentration gradient in a narrow region very close to the grain boundary to balance the concentration difference of the neighboring grains.

18.
Clinics (Sao Paulo) ; 77: 100034, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35436701

RESUMO

OBJECTIVES: To investigate the expression level and clinical significance of Methyl-CpG binding Protein 2 (MECP2) in elderly patients with hip fractures. METHODS: This prospective observational study included 367 elderly patients with hip fractures between April 2016 and December 2018. All the patients were treated with internal fixation or joint replacement. In addition, 50 healthy elderly individuals were enrolled as healthy controls. The serum levels of MECP2 and inflammatory factors Interleukin (IL)-1ß, IL-6, IL-8, and Tumor Necrosis Factor (TNF)-α was determined by enzyme-linked immunosorbent assay. Data on patients' basic characteristics and postoperative complications were collected. The Harris score was used to assess hip function at 1-month, 3-months, and 6-months after surgery. Patient quality of life was measured using the Barthel Index (BI) score 3-months after surgery. The 1-year mortality was analyzed using the Kaplan-Meier curve, and logical regression was used to analyze the risk factors for mortality. RESULTS: No significant differences were observed in the basic clinical characteristics of all patients. The serum MECP2 levels were remarkably high in patients with hip fractures and negatively correlated with serum IL-1ß, IL-6, and TNF-α levels. Patients with higher MECP2 predicted higher dynamic Harris scores, lower postoperative complications, lower 1-year mortality, and higher BI scores. Logical regression showed that age was the only independent risk factor for postoperative 1-year mortality in elderly patients with hip fractures. CONCLUSION: Lower MECP2 predicted poor prognosis and higher 1-year mortality in elderly patients with hip fractures.


Assuntos
Fraturas do Quadril , Proteína 2 de Ligação a Metil-CpG , Fatores Etários , Idoso , Artroplastia de Quadril , Estudos de Casos e Controles , Fixação Interna de Fraturas , Fraturas do Quadril/metabolismo , Fraturas do Quadril/mortalidade , Fraturas do Quadril/patologia , Fraturas do Quadril/cirurgia , Humanos , Interleucinas/metabolismo , Proteína 2 de Ligação a Metil-CpG/metabolismo , Complicações Pós-Operatórias , Prognóstico , Qualidade de Vida , Fator de Necrose Tumoral alfa
19.
J Hazard Mater ; 423(Pt A): 127069, 2022 02 05.
Artigo em Inglês | MEDLINE | ID: mdl-34482085

RESUMO

Frequent leaks of hazardous chemicals have a huge impact on human lives, property and the ecological environment. Therefore, the three-dimensional functional porous materials with high absorption efficiency and special wettability for the disposal of hazardous chemical spills is an urgent demand. In this work, a series of spherical beads consisting of partially reduced graphene oxide (prGO) and MXene (Ti3C2Tx) nanosheets were constructed by hydrogen bond induced self-assembly along with freeze-drying and thermal treatment. The lightweight and amphipathic prGO/MXene spherical beads (prGMSBDs) had millimeter-level size, spherical morphology and highly porous internal structure, which were especially suitable for eliminating hazardous chemicals. Because of their excellent thermal stability and fire retardance, the prGMSBDs could be used to absorb flammable organic liquids, reducing the fire risk of the flammable hazardous chemical spills. Indeed, the prGMSBDs exhibited outstanding absorption performances for various hazardous chemicals, including organic solvents and water-based concentrated acid and alkali. Moreover, the prGMSBDs showed relatively stable absorption performance after five absorption-drying cycles. Due to meeting the requirements of both amphipathic characteristic and flame retardancy, the prGMSBDs reported in this work may offer a promising strategy for rapidly cleaning up various hazardous chemicals and open a feasible route to protecting the combustible hazardous chemical spills from fire.


Assuntos
Retardadores de Chama , Grafite , Substâncias Perigosas , Humanos , Porosidade
20.
J Colloid Interface Sci ; 606(Pt 2): 1193-1204, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34492458

RESUMO

Electroconductive polystyrene (PS) composites with ideal flame-retardant properties are considered as potential electromagnetic interference (EMI) shielding materials. In this work, PS/silicon wrapped ammonium polyphosphate/multi-wall carbon nanotubes (PS/SiAPP/MWCNT) composites with segregated structure were synthesized via the methods of balling mill and hot-pressing. The obtained results revealed that the SiAPP and MWCNT were successfully introduced onto PS spheres and showed uniform distribution on the PS surface. The thermogravimetric analysis showed that PS/SiAPP/MWCNT containing 7 wt% MWCNT exhibited excellent thermal stability. Furthermore, the results of cone calorimeter test indicated that the heat release rate and total heat release of the PS/SiAPP/MWCNT containing a loading of 7 wt% MWCNT were reduced by 60.5% and 33.9%, respectively. In addition, the EMI shielding performance could reach 11 dB. Above results implied that the synergistic effect between the MWCNT and SiAPP effectively enhanced the flame retardant performance of the PS by promoting the generation of dense and continuous char layer to protect the PS from burning. The multiple reflection and adsorption are responsible for improved EMI shielding effectiveness. Therefore, segregated PS/SiAPP/MWCNT hybrid is an up-and-coming candidate for satisfactory EMI shielding materials with exceptional fire retardancy for electronic devices.

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