RESUMO
OBJECTIVE: To investigate the association of the polymorphism in manganese superoxide dismutase (Mn-SOD) gene in Chinese type 2 diabetic patients with diabetic retinopathy. METHODS: The Ala(-9)Val polymorphism of the Mn-SOD gene was determined by polymerase chain reaction and direct sequencing in 198 normal control subjects and 264 patients with type 2 diabetes mellitus, among them there were 139 non-diabetic retinopathy (NDR) subjects and 125 subjects with diabetic retinopathy (DR). RESULTS: There was no statistic difference in the frequencies of VV genotype and V allele between the type 2 diabetic group and the control group. However, the frequencies of VV genotype and V allele were significantly higher in the DR group than that in the NDR group (chi-square (2)=5.015, P=0.025; chi(2)=10.253, P=0.001),but there was no statistic difference in the NDR group compared with the control group (P > 0.05). The presence of V allele was shown to be associated with diabetic retinopathy (OR=1.96, 95%CI: 1.29-2.97). Furthermore, the subjects carrying the VV genotype had lower serum Mn-SOD level (P=0.025) and had a tendency of higher total serum SOD activity, but this tendency had no statistic significance. CONCLUSION: The Ala(-9)Val polymorphism in the Mn-SOD gene may not be related to the etiology of type 2 diabetes, but it seems to contribute to the development of diabetic retinopathy in Chinese type 2 diabetic patients.
Assuntos
Povo Asiático/genética , Diabetes Mellitus Tipo 2/genética , Retinopatia Diabética/genética , Polimorfismo de Nucleotídeo Único/genética , Superóxido Dismutase/genética , Alelos , DNA/análise , Diabetes Mellitus Tipo 2/complicações , Retinopatia Diabética/etiologia , Feminino , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Polimorfismo GenéticoRESUMO
OBJECTIVE: To evaluate the effects of different treatments on the prognosis of aortic dissection. METHOD: Different treatment modalities including drug therapy, surgical resection and stent implantation were performed in 37, 9, and 5 cases of aortic dissection (AD) respectively, and the clinical outcome of the patients was observed during the follow-up study. RESULTS: The survival rate in drug therapy group was 70.3% (26) while death occurred in 11 cases (29.7%). Four (44.4%) of the nine cases were cured surgically, leaving a mortality of 55.6%. Stent implantation yielded cures in 4 cases, with death occurring in 1 case, and complications arose in none of the cases. CONCLUSION: Surgical resection is superior to drug therapy in the treatment of type A AD cases, while stent implantation should be the first choice for type B AD cases for causing less complications and injuries and resulting in high cure rate.