Detalhe da pesquisa
1.
In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30910896
2.
The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530603
3.
Impact of the Major Candida glabrata Triazole Resistance Determinants on the Activity of the Novel Investigational Tetrazoles VT-1598 and VT-1161.
Antimicrob Agents Chemother
; 63(10)2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31383660
4.
The interaction of PRC2 with RNA or chromatin is mutually antagonistic.
Genome Res
; 26(7): 896-907, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27197219
5.
The Novel Fungal Cyp51 Inhibitor VT-1598 Is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis.
Antimicrob Agents Chemother
; 62(4)2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29437615
6.
Fungal-specific Cyp51 inhibitor VT-1598 demonstrates in vitro activity against Candida and Cryptococcus species, endemic fungi, including Coccidioides species, Aspergillus species and Rhizopus arrhizus.
J Antimicrob Chemother
; 73(2): 404-408, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29190379
7.
VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice.
J Antimicrob Chemother
; 73(8): 2089-2094, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29788070
8.
Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.
Antimicrob Agents Chemother
; 61(7)2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28461309
9.
Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors.
Bioorg Med Chem Lett
; 27(15): 3243-3248, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28651982
10.
Design and optimization of highly-selective fungal CYP51 inhibitors.
Bioorg Med Chem Lett
; 24(15): 3455-8, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24948565
11.
Development of Highly Selective Pyrimidine-Based Aldosterone Synthase (CYP11B2) Inhibitors.
ACS Med Chem Lett
; 10(7): 1056-1060, 2019 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31312408
12.
The Phyre2 web portal for protein modeling, prediction and analysis.
Nat Protoc
; 10(6): 845-58, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25950237
13.
Presentations to the Emergency Department Following Cannabis use--a Multi-Centre Case Series from Ten European Countries.
J Med Toxicol
; 11(4): 415-21, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25652342
14.
SuSPect: enhanced prediction of single amino acid variant (SAV) phenotype using network features.
J Mol Biol
; 426(14): 2692-701, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24810707
15.
The effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on protein-protein interactions.
J Mol Biol
; 425(21): 3949-63, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23867278
16.
Proteins and domains vary in their tolerance of non-synonymous single nucleotide polymorphisms (nsSNPs).
J Mol Biol
; 425(8): 1274-86, 2013 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23357174
17.
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.
J Med Chem
; 54(17): 6139-50, 2011 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21780790
18.
Metallophosphite-induced nucleophilic acylation of alpha,beta-unsaturated amides: facilitated catalysis by a diastereoselective retro [1,4] Brook rearrangement.
Angew Chem Int Ed Engl
; 44(16): 2377-9, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15761891
19.
Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists.
J Med Chem
; 53(11): 4531-44, 2010 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-20469868
20.
Catalytic asymmetric acylation of (silyloxy)nitrile anions.
Angew Chem Int Ed Engl
; 43(20): 2652-5, 2004 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18629980