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Int J STD AIDS ; 14(7): 478-81, 2003 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12869229

RESUMO

Differentiation between abacavir hypersensitivity and viral respiratory infections is problematic. Fifteen cases of abacavir hypersensitivity were matched to 30 controls with culture proven influenza A with no abacavir exposure. Rash was associated with hypersensitivity (odds ratio [OR] = 13.1, P = 0.02) as was the presence of nausea (OR = 30, P < 0.001), vomiting (OR = 17.1, P = 0.001) or diarrhoea (OR = 22, P < 0.001). The number of gastrointestinal symptoms was also predictive of hypersensitivity reaction (P < 0.001). Respiratory symptoms (cough, sore throat, or dyspnoea) were not associated with abacavir hypersensitivity (OR = 0.08, P = 0.001). Multivariate analysis confirmed the following associations for abacavir hypersensitivity: the number of gastrointestinal symptoms (OR = 8.6, P = 0.0032), cough (OR = 0.039, P = 0.02) and rash (OR = 16.9, P = 0.07). Abacavir hypersensitivity is strongly associated with gastrointestinal (GI) symptoms. Cough without GI symptoms is associated with influenza.


Assuntos
Fármacos Anti-HIV/efeitos adversos , Didesoxinucleosídeos/efeitos adversos , Hipersensibilidade a Drogas/diagnóstico , Vírus da Influenza A , Influenza Humana/diagnóstico , Estudos de Casos e Controles , Tosse/etiologia , Diagnóstico Diferencial , Toxidermias/etiologia , Feminino , Gastroenteropatias/induzido quimicamente , Infecções por HIV/tratamento farmacológico , Humanos , Modelos Logísticos , Masculino , Análise Multivariada , Estudos Retrospectivos
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